Researchers studying the immune response to cancer have discovered a pathway that protects mice from Alzheimer’s disease.
The pathway works by preventing the buildup of a protein called β-amyloid. The protein accumulates in the brains of Alzheimer’s patients and disrupts brain function. The buildup is a hallmark of the disease.
The shorthand name for the pathway is LANDO. This pathway also regulates inflammation, which can help rally the immune system against cancer. Chronic inflammation contributes to diseases like Alzheimer’s.
Without LANDO, β-amyloid accumulated rapidly in the mouse brains. The mice showed signs of memory loss and other problems that mimic Alzheimer’s disease. Researchers are exploring ways to regulate the pathway.
Cell published a report on this work.