Selected Publications

Wei P, Rong Y, Li L, Bao D, Morgan JI. Characterization of trans-neuronal trafficking of Cbln1. Mol Cell Neurosci 41:258-273, 2009.

Mu Q, Du G, Chen T, Zhang B, Yan B. Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes. ACS Nano 3:1139-1144, 2009.

Gromley A, Churchman ML, Zindy F, Sherr CJ. Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice. Proc Natl Acad Sci U S A 106:6285-6290, 2009.

Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A 105:20327-20332, 2008.

Inoue A, Hyle J, Lechner MS, Lahti JM. Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion. Mutat Res 657:48-55, 2008.

Ju B, Spitsbergen J, Eden CJ, Taylor MR, Chen W. Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Molecular Cancer 40:n/a, 2008.

Yogalingam G, Bonten EJ, van de Vlekkert D, Hu H, Moshiach S, Connell SA, d'Azzo A. Neuraminidase 1 is a negative regulator of lysosomal exocytosis. Dev Cell 15:74-86, 2008.

Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R, Smeyne RJ. Highly pathogenic H5N1 influenza virus can enter the central nervous system and influences neuroinflammation and neurodegeration. PNAS 106:14063-14068, 2009.

Yamashita T, Liu J, Gao J, LeNoue s, Wang C, Kaminoh J, bowne SJ, Sullivan LS, Daiger SP, Zhang K, Fitzgerald MEC, Kefalov VJ, Zuo J. Essential and synergistic roles of RP1 and RP1L1 in rod photoreceptor axoneme and retinitis pigmentosa. J Neurosci, 29:9748-9760 2009.

Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LML, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. PNAS, 106:6685-6690, 2009.

Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Wey A, Knoepfler PS, Eisenman RN, Roussel MF, Dyer MA. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev Jan 15;22(2):179-93, 2008.

Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, Ney PA. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Nat Acad Sci USA 104:19500-19505, 2007 [see addendum, Autophagy 4:354-356, 2008].

Mu Q, Lui W, Xing Y, Zhou H, Li Z, Zhang Y, Ji L, Wang F, Si Z, Zhang B, Yan B. Protein binding by functionalized multiwalled carbon nanotubes is governed by the surface chemistry of both parties and the nanotube diameter. J Phys Chem 112:3300-3307, 2008.

Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B. A Nano-Combinational library strategy for the discovery of nanotubes with reduced protein binding, cytotoxicity, and immune response. Nano Letters 8:859-865, 2008.

Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ. Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelin abnormalities. Neuroscience 151:476-488, 2008.

Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell Oct 19;131(2):378-90, 2007.

Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev Jul 15;21(14):1731-46, 2007.

Bois PR, O’Hara BP, Nietlispach D, Kirkpatrick J, Izard T. The vinculin binding site of talin and alpha-actinin are sufficient to activate vinculin. J Biol Chem 281:7228-7236, 2006.

Niikura Y, Ohta S, Vandenbeldt KJ, Abdulle R, McEwen BF, Kitagawa K. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Onocogene 25:4133-36, 2006.

Stupack DG, Teitz T, Potter MD, Mikolon D, Houghton PJ, Kidd VJ, Lahti JM, Cheresh DA. Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature 7072:95-99, 2006.

Cardone M, Polito VA, Pepe S, Mann L, d’Azzo A, Auricchio A, Ballabio A, Cosma MP. Correction of hunter syndrome in the MPSII mouse model by AAV2/8-mediated gene delivery. Hum Mol Genet 15: 1225-1236, 2006.

Krishnamurthy PC, Guoqing D, Fukuda Y, Sun D, Sampath J, Mercer K, Wang J, Sosa-Pineda B, Murti KG, Schuetz, JD. Identification of a mammalian mitochondrial porphyrin transporter. Nature 443:586-589, 2006.

Fillon S, Soulis S, Rajasekaran S, Benedict-Hamilton H, Radin J, Orihuela C, Kasmi KC, Murti G, Kaushal D, Gaber MW, Weber JR, Murray P, Tuomanen E. Platelet activating factor receptor and innate immunity: uptake of Gram positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunology 177:6182-6191, 2006.

Galea C, Bowman P, Kriwacki RW. Disruption of an intermolecular salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils. Protein Science 14:2993-3003, 2005 (featured on journal cover).

Peltola VT, Murti KG, McCullers JA. The Influenza neuraminidase contributes to secondary bacterial pneumonia. J Inf Dis 192: 249-257, 2005.

Radin JN, Orihuela CJ, Murti G, Guglielmo C, Murray PJ, Tuomanen EI. Beta arrestin 1 participates in PAFr- mediated endocytosis of Streptococcus pneumoniae. Infection & Immunity 73:7827-7835, 2005.

Izard T, Evan G, Borgon RA, Rush CL, Bircogne G, Bois PR. Vinculin activation by talin through helical bundle conversion. Nature 427:171-173, 2004.

Ramaswamy G, Karim MA, Murti KG, Jackowski S. Human PANK1 expression is regulated by PPAR alpha. J Lipid Res 45:17-31, 2004.

Brown V, Krynetski E, Krynetskaia N, Grieger D, Mukatira S, Murti KG, Slaughter C, Park H-W, Evans WE. A novel CRM1-mediated nuclear export signal governs nuclear accumulation of GAPDH following genotoxic stress. J Biol Chem 279: 5984-5992, 2004.

Yang CH, Murti A, Baker SJ, Frangou-Lazaridis M, Vartapetian AB, Murti KG, Pfeffer M. Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex. Exp Cell Res 298: 197-206, 2004 (featured on journal cover).

Nastasi T, Bongiovanni A, Campos Y, Mann L, Toy JN, Bostrom J, Rottier R, Hahn C, Conaway JW, Harris AJ, d’Azzo A. Ozz-E3, a muscle-specific ubiquitin ligase, regulates B-catenin degradation during myogenesis. Developmental Cell 6:269-282, 2004.

Tessitore A, Del PM, Sano R, Ma Y, Mann L, Ingrassia A, Laywell ED, Steindler DA, Hendershot LM, D’Azzo A. GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis. Molecular Cell 15:753-766, 2004.

Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 12:1423-1438, 2004.

Li T, Inoue A, Lahti JM, Kidd VJ. Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Mol Cell Biol 8:3188-3197, 2004.

Schwerk C, Prasad J, Degenhardt K, Erdjument-Bromage H, White E, Tempst P, Kidd VJ, Manley JL, Lahti JM, Reinberg D. ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol 8:2981-2990, 2003.

Ramos B, Lahti JM, Claro E, Jackowski S. Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. Mol Pharmacol 2:502-511, 2003.

Parfenov VN, Pochukalina GN, Davis DS, Reinbold R, Scholer HR, Murti KG. Nuclear distribution of Oct-4 transcription factor in transcriptionally active and inactive mouse oocytes and its relation to RNA polymerase II and splicing factors. J Cell Biochem 89: 720-732, 2003 (featured on journal cover).

Bakkenist CJ, Kastan M. DNA damage activates ATM through intermolecular autophosphorylation and dimer association. Nature 421:499-506, 2003.

Lee AS, Gallea, C, DiGiammarino EL, Bokkyoo J , Murti G, Riberio R, Zambetti G,Schultz C, Kriwacki R. Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant. J Mol Biol 327: 699-709, 2003.

Xue L, Morris SW, Orihuela C, Tuomanen E, Cui X, Wen R, Wang D. Defective development and function of Bcl 10-deficient follicular marginal zone and B1B cells. Nature Immunol 4:857-865, 2003.

Li L, Connelly MC, Wetmore C, Curran T, Morgan JL. Mouse embryos cloned from brain tumors. Cancer Res 63:2733-2736, 2003 (featured on journal cover).

Lieberman MC, Gao J, He DZZ, Wu, X, Jias S, Zuo J. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 419:300-304, 2002.

Braun SJ, Sublett JE, Freyer D, Mitchell TJ, Cleveland JL, Tuomanen EI, Weber JR. Pneumococcal pneumolyin and H(2)O(2) mediate brain stem apoptosis during meningitis J Clin Invest 109:19-27, 2002.

Bothner B, Lewis WS, DiGiammario EL, Weber JD, Bothner SJ, Kriwacki RW. Defining the molecular basis of Arf and Hdm2. J Mol Biol 314:263-277, 2001.