Improved Human Carboxylesterase for Therapy with CPT-11 (SJ-06-0006)

St. Jude Reference #SJ-06-0006

Description

Researchers at St. Jude have generated a human carboxylesterase that efficiently activates the anticancer drug CPT-11. This was performed using site directed mutagenesis of hCE1 using information provided by the crystal structures of wildtype hCE1 and a rabbit liver CE (rCE).

Previous research developed enzyme/prodrug therapy approaches using rCE and CPT-11, this novel enzyme (hCE1mut6), would replace the rabbit protein in these studies and be much more likely to be used in any clinical application of this technology.


 

Keywords

Carboxylesterase, enzyme, cancer, drug, CPT-11


 

Granted Patents or Published Applications

US 7,906,637; 8,124,393; US Pub. 2012/0142108


 

Related Scientific References

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11”, Cancer Gene Therapy (2008) 15:183-192.


 

Licensing Opportunities

We are looking for a commercial partner to license this discovery and develop, market, and sell commercial applications. Contact: chad.riggs@stjude.org

Related Links

 

Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.