Method for Enhancing Recombinant Antibody Production (SJ-08-0032)

St. Jude Reference #SJ-08-0032

Description

A method for enhancing recombinant antibody production by co-expressing a recombinant antibody with the ERp23 protein. The ERp23 protein facilitates oxidative folding and stability of the recombinant antibody which enhances its production. This invention may be used in the production of therapeutic antibodies.


 

Keywords

Therapeutic antibody production


 

Granted Patents or Published Applications

U.S. Patent No. 8,030,0027


 

Related Scientific References

Shimizu Y, Meunier L, Hendershot LM; pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17013-8.


 

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