Phase Cycled Magnetic Resonance Spectroscopic Imaging (SJ-15-0032)

St. Jude Reference #SJ-15-0032

Description

Magnetic resonance spectroscopic imaging (MRSI) has become an important tool in clinical settings for noninvasively obtaining spatial and metabolic information on a molecular scale. However, conventional MRSI has not been widely used in clinical studies mainly because its data acquisition is very time consuming, it has a restricted spatial coverage and a complex scan procedure for lipid suppression. The precise placement of the many lipid suppression bands is challenging and time consuming, and it requires a skilled technician with special training. In addition, conventional MRSI usually has relative low signals for J-coupled metabolites, which could provide very important biomarkers for different diseases.

Researchers at St. Jude have developed a novel, fast MR spectroscopic imaging technique, termed phase-cycled spectroscopic imaging (PCSI). PCSI has the following advantages over the conventional MRSI techniques.

  • PCSI can achieve very high acquisition efficiency with a short repetition time enabling PCSI to acquire MRSI images up to 100 times faster than conventional MRSI techniques.
  • PCSI offers intrinsic water and fat suppression, thereby greatly simplifying the scanning procedures and more closely resembling routine clinical scans.
  • Using an ultra-low flip angle, PCSI greatly reduces RF energy deposition in subjects thousands of times compared to conventional spectroscopy sequences.
  • PCSI provides higher signals for J-coupled metabolites due to a short echo time, which may make PCSI a great tool for measuring these metabolites.

The PCSI method provides a simple, flexible, and efficient way to perform MR spectroscopic imaging in the frequency domain which may enable spectroscopic imaging to play a larger role in the clinical applications.


 

Keywords

Magnetic Resonance Spectroscopic Imaging


 

Granted Patents or Published Applications

Pending application filed


 

Related Scientific References

Guo, J. et al. Fast frequency-sweep spectroscopic imaging with an ultra-low flip angle. Sci. Rep. 6, 30066; doi: 10.1038/srep30066 (2016).


 

Licensing Opportunities

We are currently seeking licensing opportunities for the development of this technology. Contact: chad.riggs@stjude.org

Related Links

Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.