Description
An 8 plasmid system has been developed for generating RNA viruses from cloned DNA. This system may be used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome. This system may be used to quickly and easily generate a genetically engineered version of any RNA virus.
Keywords
RNA viruses, reverse genetics, 8 plasmid system
Granted Patents or Published Applications
U.S. Patent Nos. 6,951,754 and 7,312,064; granted patents and pending applications in several countries
Related Scientific References
Hoffmann E, et al.,” Eight-plasmid system for rapid generation of influenza virus vaccines”, Vaccine 20(25-26):3165-70 (2002);
Hoffmann E and Webster RG, “Unidirectional RNA polymerase I-polymerase II transcription system for the generation of influenza A virus from eight plasmids” J Gen Virol. 81(Pt 12):2843-7 (2000).
Licensing Opportunities
We are currently seeking licensing opportunities in fields outside of influenza virus diagnosis, prevention and/or treatment in humans. Contact: chad.riggs@stjude.org
Related Links
- Attenuated Streptococcus Pneumoniae Strain and Vaccine for Protection Against Pneumococcal Disease (SJ-11-0001)
- Avian Influenza Vaccine (SJ-06-0013)
- Group B Streptococcus (GBS) Extracellular Matrix Adhesion Proteins (SJ-00-0030)
- Improved System for Generating Human Influenza Vaccine in Cell Tissue Culture (SJ-02-0016)
- Methods and Composition for Diagnosing and Preventing a Group B Streptococcal Infection (SJ-02-0032)
- Modified Influenza Virus for Monitoring and Improving Vaccine Efficiency (SJ-04-0033)
- Modified Sendai Virus Vaccine and Imaging Vector (SJ-11-0018)
- Screen to Identify Pneumococcal Proteins that Inhibit Transmission Rather than Invasive Disease (SJ-18-0045)
- Screen to Identify Pneumococcal Proteins that Inhibit Transmission Rather than Invasive Disease (SJ-18-0045)
- Synthetic Vaccine and Immunogenic Fusion Proteins for Pneumococcal Infections, and uses (SJ-05-0036, SJ-10-0028, SJ-13-0032)
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.