New method for differentiating T-cells (SJ-18-0019)

St. Jude Reference #SJ-18-0019


Researchers at St. Jude have invented a novel way to expand chimeric antigen receptor (CAR) T cells that work better for gene therapy. These T cells could form the basis of the next generation of CAR therapies that provide sustainable, superior antitumor activity.

Incorporating IL-12 in in vitro culture conditions results in the generation of stem cell memory (Tscm) cells, which possess an enhanced ability to eradicate tumors without reaching exhaustion.


cer, immunology, chimeric antigen receptor (CAR), T cell, stem cell memory (Tscm) cells, epigenetic, IL-12, expansion

Granted patents or published applications

Pending PCT, published as WO 2020/012331.

Related scientific references

Knocking out specific gene prevents T-cell exhaustion, boosts CAR T-cell responses

Brooke Prinzing et al, Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity, Science Translational Medicine (2021). DOI: 10.1126/scitranslmed.abh0272

Licensing opportunities

St. Jude is seeking a partner or partners to help develop this for use with therapies. Contact:

Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.