The Tissue Resources Laboratory processes and archives tumor tissue, normal tissues, and body fluids for use in clinical and basic research. The resource maintains banks of cryopreserved cell suspensions, frozen tissue blocks, DNA samples, and frozen serum. Materials from this resource are available to investigators who attain approval from the institution's Tissue Resource Committee.
The Archives contain samples of human solid tumors, normal tissues and aliquots of white blood cells collected at diagnosis, and at various subsequent points. Serum and plasma collected at diagnosis and at intermittent periods are also banked. Tumor tissues are stored in aliquots of cryopreserved single-cell suspensions (teased tissue), frozen tissue blocks and extracted DNA.
Any faculty member of St. Jude Children’s Research Hospital may contact the TPL for types and availability of stored tissues, and subsequently petition the Tissue Resources Committee (TRC) for the samples. Investigators from other institutions may contact TRC with requests for tissues only if they are involved in collaboration with a St. Jude faculty member. Protection of patient confidentiality and respect of patient autonomy are among the most important ethical principles of TPL. All dispensed tissues are strictly anonymized and are consented for by the patient or their legal guardian.
The Tissue Resource Committee consists of at least six St. Jude faculty members and is charged with: