Fatima Rivas, PhD
Fatima Rivas, PhD

Fatima Rivas, PhD

Assistant Member, St. Jude Faculty

Departments

Education

BS – California State University, Dominguez Hills, Carson, California
MS – University of California, San Diego, La Jolla, California
PhD – University of California, San Diego, La Jolla, California

Honors & Awards

  • 2012 Keystone Symposia Early Career Investigator Travel Award
  • 2011 Carl Storm Underrepresented Minority Fellowship
  • 2009-2010 Keystone Symposia on Molecular and Cellular Biology Fellowship
  • 2006-2010 IRACDA Postdoctoral Fellow, University of California San Diego, and San Diego State University
  • 2002-2006 The Institute on Teaching and Mentoring Southern Regional Education Board/NSF Alliances for Graduate Education and the Professoriate Scholar Program Fellowship
  • 2002-2006 Ruth L. Kischstein National Research Service Award Individual Pre-doctoral Fellowship

Research Interests

  • Target oriented chemical synthesis of novel natural products from terrestrial plants, guided by certain tropical folk medicine (such as the Erythrina alkaloids and the Trichothecenes).
  • Upon the development of flexible and efficient synthetic approaches, rational-designed libraries will be synthesized for biological screening, and facilitate the development of therapeutic agents for the treatment of cancer and metabolic syndrome-related disorders.
  • Isolation and structure elucidation of natural products of medicinal interest.

Selected Publications

Hamulić D, Stadle, M, Hering S, Padrón JM, Bassett R, Rivas F, Dea-Ayuela MA, González-Cardenete MA. First Synthesis and Biological studies of the Abietane (+)-liquiditerpenoic acid A (abietopinoic acid) and some analogues: SAR studies. J. Nat. Prod. 82 (4), 823-831, 2019.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens N, Dorjsuren D, Eastman RT, Huang R, Iannotti M, Karavadhi S, Klumpp-Thomas C, Roth J, Sakamuru S. Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman R, Hughes CC, Johnston JN, Joullié MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE. Brown LE,  Snyder JK, A Porco Jr, J, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z. Shen B, Shi W, Stephenson C, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.  Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space. Chemrxiv.  https://doi.org/10.26434/chemrxiv.7172369.v1 .  ACS Cent. Sci., 4(12), 1727-1741, 2018.

Stoddard SV, May X, Rivas F, Dodson K, Vijayan S, Adhika S, Parker K, Watkins D. Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8). Molecular Informatics. 37, 1800080, 2018. doi: 10.1002/minf.201800080. PMID:30369061. 

Fatima I, El-Ayachi I, Ling T, Lillo MA, Krutilina R, Seagroves TN, Radaszkiewicz TW, Hutnan M, Bryja V, Krum SA, Rivas F, Miranda-Carboni GA. The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. PLoS One.  12(12): e0189864, 2017.

Ling T, Miller DJ, Lang WH, Griffith E, Rodriguez-Cortes A, El-Ayachi I, Palacios G, Min J, Miranda-Carboni G, Lee RE, Rivas F*. Mechanistic insight on the mode of action of colletoic acid. J. Med. Chem. 2019 Jul 24. doi: 10.1021/acs.jmedchem.9b00187.  

Ling T, Lang WH, Maier J, Rivas F*. Cytostatic and cytotoxic natural products against cancer cellular models. Molecules. 2019 May 26;24(10). pii: E2012. doi: 10.3390/molecules24102012.

Ling T, Lang WH, Craig J, Potts MB, Budhraja A, Opferman J, Bollinger J, Rivas F*. Studies of Jatrogossone A from Jatropha gossypiifolia as a reactive oxygen species inducer in cancer cellular models. J Nat. Prod. 2019 May 14. doi: 10.1021/acs.jnatprod.8b01087. PMID: 31084028

Ling T, Lang WH, Martinez-Montemayor M*, Rivas F*. Development of ergosterol peroxide probes for cellular localization studies. Org. Biomol. Chem. 2019 Apr 26. doi: 10.1039/c9ob00145j. (Front cover, Ed. 17).

Ling T, Meir J, Das S, Budhraja A, Bassett R, Potts M, Shelat A, Rankovic Z, Opferman JT*, Rivas F*. Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents. Eur. J. Med. Chem. 164, 391-398. 2018. PMID:30611980

Martínez-Montemayor* MM, Ling T, Suárez-Arroyo IJ, Ortiz Soto G, Negrón CS, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F*. Identification of biologically active Ganoderma lucidum compounds and synthesis of novel and improved derivatives that confer anti-cancer activities tested in different in vitro cancer models. Front. Pharmacol. 10:115, 1-17, 2019.

Ling T, Lang W, Feng X, Das S, Maier J, Jeffries C, Shelat A, Rivas F*.  Novel vitexin-inspired scaffold against leukemia. Eur. J. Med. Chem. 146, 501-510, 2018. PMID:29407975

Rivas F*, Ling T. All- carbon quaternary centers in natural products and medicinal chemistry: recent advancements. Tetrahedron, 72, 6729-6777, 2016.

Rivas F*, Ling T. Synthetic advances towards functionalized γ-lactams featuring (-)- salinosporamide A and related natural products. Org Prep and Proced Int. 3, 254-295, 2016.

Gautam LN, Ling T, Lang W, Rivas F*. Anti-proliferative evaluation of monoterpene derivatives against leukemia. Eur. J. Med. Chem., 113, 75-80, 2016.

O Ling T, Gautam LN, Griffith E, Das S, Lang W, Shadrick WR, Shelat A, Lee RE, Rivas F*. Synthesis and evaluation of colletoic acid core derivatives. Eur. J. Med. Chem. 110 126-132, 2016.

Last update: October 2019