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Erin G. Schuetz, PhD
Erin G. Schuetz, PhD


PhD – Medical College of Virginia/VCU, Richmond
BS – St. Mary's College, Notre Dame, Indiana

Research Interests

  • Regulation of cytochrome P4503A
  • Interplay of drug transport, cytochromes P450 and nuclear hormone receptors
  • Pharmacogenetics of drug transporters, cytochromes P450 and nuclear hormone receptors
  • Arachnoid Barrier drug transporters - contribution to the blood-CSF barrier

The influence of Pqp on CYP3A regulation    

Selected Publications

Yasuda K, Cline C, Lin YS, Scheib R, Ganguly S, Thirumaran R, Chaudhry AS, Kim RB, Schuetz EG. In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice. Drug Metab Dispos Nov;43(11):1646-54, 2015.  

Chaudhry A, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu S, Aklillu E, Sim S, Thummel KE, Schuetz EG. The CYP2C19 intron 2 branch point SNP is the ancestral polymorphism contributing to the poor metabolizer phenotype in livers with CYP2C19*35 and CYP2C19*2 alleles. Drug Metab Dispos Aug;43(8):1226-35, 2015. PMCID: PMC4518065

Chaudhry AS, Thirumaran RK, Yasuda K, Yang X, Guengerich FP, Strom SC, Schuetz EG. Genetic variation in Aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple Cytochrome P450s. Drug Metab Dispos 41(8):1538-47, 2013. PMCID: PMC3701191. Selected for DMD Highlights on the ASPET website and Selected as 2013 ASPET James R. Gillette DMD Best Paper Award

Yasuda K, Cline CB, Vogel P, Onciu M, Fatima S, Sorrentino BP, Thirumaran RK, Ekins S, Urade Y, Fujimori K, Schuetz EG. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood-cerebrospinal Fluid Barrier. Drug Metab Dispos Apr 41(4):923-31, 2013. PMCID: PMC3608452.

Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Qi A, Cheng C, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochem Pharmacol Jul 1;84(1):104-12, 2012. PMCID: PMC3774043

Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich F, Strom SC, Schuetz EG, Rushmore T, Ulrich R, Slatter J, Schadt EE, Kasarskis A, Lum P. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res 20:1020-36, 2010. PMCID: PMC2909567.

Chaudhry AS, Urban TJ, Lamba JK, Birnbaum AK, Remmel RP, Strom S, You JH, Liu, D, Singh R, Kasperaviciute D, Catarino C, Radtke R, Sisodiya SM, Goldstein DB, Schuetz EG. CYP2C9*1B promoter SNPs, in LD with CYP2C19*2, affect phenytoin auto-induction of clearance and maintenance dose. J Pharmacol ExpTher 332(2):599-611, 2010. PMCID: PMC2812115. Highlighted paper for February, 2010 Issue of JPET

Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey J, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz EG, Rushmore TH, Ulrich R. Mapping the genetic architecture of gene expression in human liver. PLoS Biol 6(5):e107, 2008. PMCID: PMC2365981

Poonkuzhali B, Lamba J, Strom S, Sparreboom A, Thummel K, Watkins P, Schuetz EG. Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms. Drug Metab Dispos 36:780-95, 2008. Selected as 2009 ASPET James R. Gillette DMD (Drug Metabolism & Transporter Division) Best Paper Award

Krasowski MD, Yasuda K, Hagey LR, Schuetz EG. Evolution of the pregnane X receptor: adaptation to cross-species differences in biliary bile salts. Mol Endocrinol Jul;19(7):1720-39, 2005. PMCID: PMC1262763

Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG. Natural allelic variants of BCRP and their relationship to BCRP expression in human intestine.  Pharmacogenetics 13:19-28, 2003.

Zheng H, Webber S, Zeevi A, Schuetz E, Zhang J, Bowman P, Boyle G, Law Y, Miller S, Lamba J, Burckart GJ. Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms. Am J Transplan 3(4):477-83, 2003.

Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Lamba J, Kim, RB, Ramachandran V, Komoroski BJ, Venkataramanan R,  Cai H,  Sinal C, Gonzalez FJ, Schuetz JD. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters and cytochrome P450. J Biol Chem 276:39411-39418, 2001.

Thummel KE, Brimer C, Yasuda K, Thottassery J, Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, Schuetz EG.  Transcriptional control of intestinal CYP3A4 by 1α,25-dihydroxy vitamin D3. Mol Pharm 60:1-8, 2001.

Schuetz EG, Strom S. Promiscuous regulator of xenobiotic removal. Nat Med May;7(5):536-7, 2001.

Kuehl P, Zhang J, Lin Y, Lamba J., Assem M, Schuetz J, Watkins P, Maurel P, Daly A, Wrighton S, Hall SD, Relling M, Schuetz J, Brimer C, Yasuda K, Strom S, Thummel K, Boguski MS, Schuetz EG. Sequence Diversity in CYP3A promoters and characterization of the genetic basis for polymorphic CYP3A5 expression. Nat Genet 27:383-391, 2001.

Lan, L-B, Dalton JT, Schuetz EG. Mdr1 limits CYP3A metabolism in vivo. Mol Pharmacol 58:8863-8869, 2000.

Brimer C, Dalton JT, Zhu Z, Schuetz J, Yasuda K, Vanin E, Relling MV, Lu Y, Schuetz EG. Creation of polarized cells co-expressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein. Pharmaceut Res 17:803-810, 2000.  AAPS (American Association of Pharmaceutical Scientists) Meritorious Manuscript Award – recognizes achievement in the pharmaceutical sciences. The scientific impact of the published work is the principle used in nominating the paper – based on new concepts and new experimental procedures.

Schuetz EG, Schmid W, Schutz G, Brimer C, Yasuda K, Kamataki T, Bornheim L, Myles K, Cole TJ. The glucocorticoid receptor is essential for induction of cytochrome P4502B by steroids but not for drug or steroid induction of CYP3A or P450 reductase in mouse liver.  Drug Metab Disp 28:268-278, 2000. Selected as 2001 ASPET James R. Gillette DMD (Drug Metabolism Division) Best Paper Award

Schuetz EG, Schinkel AH. Drug disposition as determined by the interplay between drug-transporting and drug-metabolizing systems. J Biochem Mol Toxicol 13:219-222, 1999.

Schuetz EG, Brimer C, Schuetz J. Environment xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYPA23 hormone response element. Mol Pharmacol 54:1113-1117, 1998.

Schuetz EG, Schinkel AH, Relling MV, Schuetz JD. P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci 93:4001-4005, 1996.

Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.  Mol Pharmacol 49:311-318, 1996.

Watkins PB, Wrighton SA, Schuetz EG, Molowa DT, Guzelian PS.  Identification of glucocorticoid-inducible cytochrome P‑450 in the intestinal mucosa of rats and man. J Clin Invest 80:1029-1036, 1987.

Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS. Complete cDNA sequence of a cytochrome P‑450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci 83:5311-5315, 1986.

Schuetz EG, Wrighton SA, Safe SH, Guzelian PS. Regulation of cytochrome P‑450 by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo. Biochemistry 25:1124-1133, 1986.

Schuetz EG, Guzelian PS. Induction of cytochrome P‑450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P‑450 by a non-classical receptor mechanism. J Biol Chem 259:2007-2012, 1984.

Last update: October 2015