Richard J. Smeyne, PhD
Richard J. Smeyne, PhD

Richard J. Smeyne, PhD

Member, St. Jude Faculty



BS – St. Joseph's University, Philadelphia, PA (1981)
MA – University of Hartford, West Hartford, CT (1983)
PhD – Thomas Jefferson University, Philadelphia, PA (1989)
Postdoctoral Training – Department of Neuroscience, Roche Institute of Molecular Biology, Nutley, NJ

Research Interests

  • Experimental models of Parkinson's disease
  • Role of viral infection in neurodegenerative disease

Effects of exposure to drugs of abuse on the development of the CNS

Genes that regulate sensitivity to the Parkinsonian drug MPTP

The role of environment in neuroprotection

Selected Publications

Sadasivan S, Pond BB, Pani AK, Qu C, Jiao Y, Smeyne RJ. Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the Basal Ganglia of mice. PLoS One 7(3):e33693, 2012.

Jang H, Boltz D, McClaren J, Pani AK, Smeyne M, Korff A, Webster R, Smeyne RJ. Inflammatory effects of highly pathogenic H5N1 influenza virus infection in the CNS of mice. J Neurosci 32(5):1545-59, 2012.

Jiao Y, Lu L, Williams RW, Smeyne RJ. Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. PLoS One 7(1):e29447, 2012. PMID: 22291891

McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell Aug 16;20(2):260-75, 2011. PMID: 20840489.

Korff A, Pfeiffer B, Smeyne M, Kocak M, Pfeiffer RF, Smeyne RJ. Alterations in glutathione S-transferase pi expression following exposure to MPP(+)-induced oxidative stress in the blood of Parkinson's disease patients. Parkinsonism Relat Disord Aug;17(1):765-8, 2011. PMID: 20840241.

Henry J, Smeyne RJ, Jang H, Miller B, Okun MS. Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries. Parkinsonism Relat Disord Nov;16(9):566-71, 2010. PMID: 20106867.

Lloyd SA, Balest ZR, Corotto FS, Smeyne RJ. Cocaine selectively increases proliferation in the adult murine hippocampus. Neurosci Lett Nov 19;485(2):112-6, 2010. PMID: 20817079.

Gerecke KM, Jiao Y, Pani A, Pagala V, Smeyne RJ. Exercise protects against MPTP-induced neurotoxicity in mice. Brain Res Jan 29 1341:72-83, 2010. PMID: 20116369.

Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated {alpha}-synuclein gene mutations precede central nervous system changes. Hum Mol Genet 19(9):1633-50, 2010. PMID: 20106867.

Burton AR, Baquet Z, Eisenbarth GS, Tisch R, Smeyne R, Workman CJ, Vignali DA. Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4(+) T cells. J Immunol 184:4863-4870, 2010.

Zigmond MJ, Cameron JL, Leak RK, Mirnics K, Russell VA, Smeyne RJ, Smith AD. Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.Parkinsonism Relat Disord Dec;15 Suppl 3:S42-5, 2009. PMID: 20083005.

Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R, Smeyne RJ. Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci USA 106(33):14063-8. 2009. PMID: 19667183.

Baquet ZC, Williams D, Brody J, Smeyne RJ. A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse. Neuroscience 2161(4):1082-90. 2009. PMID: 19376196.

Chen P-C, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Johnson JA. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's Disease: a critical role for the astrocyte.Proc Nat Acad Sci USA 106(8):2933-8. 2009. PMID: 19196989.

Jang H, Boltz DA, Webster RG, Smeyne RJ. Viral parkinsonism. Biochim Biophys Acta Aug 12, 2008. PMID: 18760350.

Holst J, Wang H, Durick Eder K, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A,Smeyne R, van Oers NSC, Utz PJ, Vignali DAA. T cell receptor:CD3 ITAM-mediated scalable signaling ensures effective negative selection and prevents autoimmunity. Nature Immunology 9(6):658-66. 2008. PMID: 18469818.

Wei P, Smeyne RJ, Bao D, Parris J, Morgan JI. Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons. Eur J Neurosci 26:2962-78, 2007. PMID: 18001291.

Pattarini R, Smeyne RJ, Morgan JI. Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson’s disease. Neuroscience 145:654-668, 2007. PMID: 17258864.

Boyd JD, Jang H, Shepherd KR, Faherty C, Slack S, Jiao Y, Smeyne RJ. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain Res 1175:107-16, 2007 PMID: 17884023.

Smeyne M, Boyd J, Shepherd KR, Jiao Y, Pond BB, Hatler M, Wolf R, Henderson C, Smeyne RJ. GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. PNAS 104(6):1977-1982, 2007. PMID: 17267597.

Lloyd SA, Faherty CJ, Smeyne RJ. Adult and in utero exposure to cocaine alters sensitivity to the Parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience 137:905-913, 2006. PMID: 16298078.

Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Elberger A, Hamre K, Smeyne R, Chesler E, Goldowitz D. Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age 27:75-90. 2006.

Jackson-Lewis V, Smeyne RJ. MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity.Neurotox Res 7(3):193-201, 2005. PMID: 15897154.

Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ. Glia cell number modulates sensitivity to MPTP in mice. Glia 52:144-152, 2005. PMID: 15920722.

Faherty CJ, Shepherd KR, Herasimtschuk A, Smeyne RJ. Environmental enrichment eliminates neuronal death in experimental Parkinsonism. Mol Brain Res 134: 170-179, 2005. PMID: 15790541.

Smeyne RJ, Jackson-Lewis V. The MPTP model of Parkinson’s disease. Brain Res Mol Brain Res 134:57-66, 2005. PMID: 15790530.

Lewis PM, Griti-Linde A, Smeyne R, Kottmann A, McMahon AP. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol 270:393-410, 2004.

Jensen P, Smeyne RJ, Zoghbi HY, Goldowitz D. Analysis of cerebellar development in math1 null embryos and chimeras. J Neurosci 24:2202-2211, 2004. PMID: 14999071.

Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne RJ, Rehg JE, Eberhart C, Sherr CJ, Roussel MF. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res63: 5420-5427, 2003. PMID: 14500377.

Lloyd SA, Wensley B, Faherty CJ, Smeyne RJ. Regional differences in cortical dendrite morphology following in utero exposure to cocaine. Brain Res Dev Brain Res 147:59-66, 2003. PMID: 12644248.

Faherty CJ, Kerley D, Smeyne RJ. A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Brain Res Dev Brain Res 141:55-61, 2003. PMID: 12644248.

Cook R, Lu L, Gu J, Williams RW, Smeyne RJ. Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res 110:279-288, 2003. PMID: 12591164.

Last update: April 2012