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    Martine F. Roussel, PhD

    Martine F. Roussel, PhD

    Genes team up to suppress brain tumor

    The Ink4c and Ptch1 genes collaborate to suppress the development of the brain tumor medulloblastoma, according to a team led by St. Jude Children's Research Hospital investigators. The Ink4c and Ptch1 collaboration occurs independently of another anti-cancer collaboration: that of Ptch1 with the p53 gene, the researchers said.

    The discovery sheds new light on how cells in the cerebellum called granule neuronal precursor cells (GNPs) give rise to medulloblastoma when certain genes are absent or functioning abnormally.

    A report on this work appears in the November 15 issue of Genes & Development and is currently available online.

    The St. Jude Pediatric Brain Tumor Program will now try to determine if the absence or presence of the Ink4c gene or its protein in medulloblastoma cells can help doctors predict patient outcomes, according to the paper’s senior author, Martine Roussel, PhD, St. Jude Genetics and Tumor Cell Biology. Tamar Uziel, PhD, and Frederique Zindy, both of St. Jude Genetics and Tumor Biology, did much of the lead work on this project.

    Other St. Jude authors of this study include Antoine Forget, Youngsoo Lee, PhD, Peter McKinnon, PhD, Charles Sherr, MD, PhD, and Suqing Xie, St. Jude Genetics and Tumor Cell Biology; Christopher Calabrese, PhD, Tom Curran, PhD, Richard Gilbertson, MD, PhD, and Susan Magdaleno, St. Jude Developmental Neurobiology; Jerold Rehg, DVM, St. Jude Pathology; and Sarah Sherr, MD, St. Jude Hematology-Oncology.


    Last update: December 2005