Research Faculty

The faculty below conduct basic and translational research at St. Jude Children's Research Hospital.

James M. Boyett, PhD (Dept. Chair) Statistical design and analysis of clinical trials
Cheng Cheng, PhD Statistical methods in cancer genomics and genetics
Guolian Kang, PhD Statistical genetics and genomics, modeling of complex data
Yimei Li, PhD Statistical analysis of complex imaging data
Arzu Onar-Thomas, PhD Phase I-II designs, survival analysis, Bayesian statistics
Stanley B. Pounds, PhD Development of statistical methods for genomics studies
Deo Kumar Srivastava, PhD Clinical trials, robust methods, survival analysis
Li Tang, PhD Measurement error & classification; longitudinal modeling; complex epidemiologic study design
Jianrong (John) Wu, PhD Design and analysis of preclinical and clinical trials
Hui Zhang, PhD Statistical methods for psychological research
Liang Zhu, PhD Survival analysis and longitudinal data analysis
Bone Marrow Transplant & Cellular Therapy
Lea Cunningham, MD Novel therapies and preclinical models for relapsed and refractory pediatric cancer
Mari H. Dallas, MD Cord blood transplantation and immune reconstitution
William Janssen, PhD Cellular therapeutics, and immunotherapy of cancer
Wing H. Leung, MD, PhD (Dept Chair) NK cell and stem cell transplantation, late effects
Asha Pillai, MD Immunobiology of alloregulation, engraftment, and GVHD
Cell & Molecular Biology
Stacey K. Ogden, PhD Mechanisms of Hedgehog signal transduction
Joseph T. Opferman, PhD Regulation of cell death during hematopoiesis
J. Paul Taylor, MD, PhD (Dept Chair) Molecular genetics of neurological diseases
Chemical Biology & Therapeutics
Taosheng Chen, PhD Small-molecule transcription factor drug discovery
Naoaki Fujii, PhD Medicinal chemistry, chemical biology, PDZ domain
R. Kiplin Guy, PhD (Dept Chair) Chemical biology and orphan disease drug discovery
Richard Lee, PhD Development of new chemotherapeutic agents
Philip M. Potter, PhD Anticancer drug hydrolysis by carboxylesterases
Fatima Rivas, PhD Organic chemistry synthesis/natural product discovery
Anang Shelat, PhD Multi-scale modeling of biological and chemical data
Computational Biology
Jinghui Zhang, PhD Computational biology, genetic alterations in cancer
Developmental Neurobiology
Suzanne J. Baker, PhD PTEN and key signaling pathways in brain tumors
Xinwei Cao, PhD Growth control during neural tube development
Fabio Demontis, PhD Mechanisms of muscle aging, proteostasis, and myokine signaling
Michael A. Dyer, PhD Retinal development and retinoblastoma
Richard J. Gilbertson, MD, PhD The cellular and molecular origins of brain tumors
Young Goo Han, PhD Primary cilia in brain development and tumorigenesis
Myriam Labelle, PhD Role of platelets in cancer metastasis
James I. Morgan, PhD (Dept Chair) Control of neuronal death and differentiation
Jamy Peng , PhD Epigenetic regulation of stem cell identity and functions
Richard J. Smeyne, PhD Role of viruses, inflammation, and oxidative stress in neurodegeneration
David J. Solecki, PhD Cell polarity in neuron precursor differentiation
Stanislav S. Zakharenko, MD, PhD Learning and memory, synaptic mechanisms of schizophrenia
Liqin Zhu, PhD Liver tumorigenesis and development of novel therapies for pediatric hepatoblastoma
Jian Zuo, PhD Auditory hair cell function and regeneration in mice
Epidemiology & Cancer Control
Tara M. Brinkman, PhD Psychosocial outcomes of childhood cancer
Cheryl Cox, PhD Health promotion, early/late effects of treatment
Todd M. Gibson, PhD Risk factors for late effects after pediatric cancer
I-Chan Huang, PhD Patient-centered approach to assess and improve health outcomes in cancer survivors
Robert C. Klesges, PhD Cancer prevention and control in adults and children
Kevin R. Krull, PhD Neurocognitive outcomes of pediatric cancer
Kirsten K. Ness, PT, PhD Functional limitations among cancer survivors
Rohit Ojha, PhD Health outcomes among childhood cancer survivors
Leslie L. Robison, PhD (Dept Chair) Pediatric cancer epidemiology and outcomes
Alessandra d’Azzo, PhD Intracellular degradation in development and disease
Gerard C. Grosveld, PhD (Dept Chair) The role of chromosome translocations in cancer
Peter J. McKinnon, PhD DNA damage responses in the nervous system
Guillermo C. Oliver, PhD Development of the CNS and lymphatic vasculature
Beatriz Sosa-Pineda, PhD Pancreas and liver organogenesis in mammals
Wilson Clements, PhD Vascular/hematopoietic development and leukemia
Shannon McKinney-Freeman, PhD Mechanisms of hematopoietic stem cell development
Arthur W. Nienhuis, MD Genetic therapy of hematological diseases
Brian P. Sorrentino, MD Gene therapy and hematopoietic stem cell biology
Mitchell, J. Weiss, MD, PhD (Dept Chair) The role of transcription factors in hematopoietic cell development and differentiation
Mark Bix, PhD Cytokine gene regulation in T-cell differentiation
Hongbo Chi, PhD Cellular signaling in innate and adaptive immunity
Peter C. Doherty, PhD Molecular and cellular analysis of CD8+T cells
Douglas R. Green, PhD (Dept Chair) Apoptosis, autophagy, and mitochondria
Thirumala-Devi Kanneganti, PhD Mechanisms of host defense and inflammation
Maureen A. McGargill, PhD T cell regulation to treat autoimmune diseases
Paul G. Thomas, PhD Innate and adaptive immunity to influenza
Benjamin A. Youngblood, PhD T-cell memory differentiation and exhaustion
Infectious Diseases
Hans Haecker, MD, PhD Signal transduction of Toll-like and TNF receptors
Julia L. Hurwitz, PhD Vaccine-induced immunity
Suzanne Jackowski, PhD Phospholipids and coenzyme A in health and disease
Jonathan McCullers, MD Interactions between bacteria and viruses
Peter J. Murray, PhD Control of inflammatory responses
Charles O. Rock, PhD Membrane phospholipid metabolism
Jason W. Rosch, PhD Bacterial genomics and pathogenesis
Charles J. Russell, PhD Respiratory viruses: disease, cures, and prevention
Stacey Schultz-Cherry, PhD Pathogenesis of influenza virus and astrovirus
Amber Smith, PhD Kinetic modeling of viral and bacterial coinfection pathogenesis
Elaine I. Tuomanen, MD (Dept Chair) Pathogenesis of pneumococcal infection
Richard J. Webby, PhD Influenza virus pathogenicity
Charles Gawad, MD, PhD Studying the cellular and genetic origins of childhood cancers using single-cell genomics
Kevin Freeman, PhD Genetic interactions that give rise to neuroblastoma
Tanja A. Gruber, MD, PhD Pathogenesis of infantile leukemia
Mark Hatley, MD, PhD Origins of pediatric sarcomas
Kim Nichols, MD Immunodeficiency, autoimmunity and cancer
John Choi, MD, PhD Transcription factors in acute leukemias
James R. Downing, MD (Pres & CEO) The molecular pathology of acute leukemia
David Ellison, MD, PhD (Dept Chair) Pathologic and molecular characterization of CNS tumors
Terrence L. Geiger, MD, PhD T-cell regulation, autoimmunity
Jeffery Klco, MD, PhD Hematopoietic development and malignancy, Notch signaling
Mondira Kundu, MD, PhD The role of autophagy in erythroid maturation and anemia
Vasiliki Leventaki, MD Mechanisms of pathogenesis in pediatric lymphomas
Charles G. Mullighan, MD Genomic profiling of acute leukemia
Leta K. Nutt, PhD Metabolic regulation of cancer cell death
Janet F. Partridge, PhD Chromosome segregation, heterochromatin assembly
Gerard P. Zambetti, PhD p53 function in tumor suppression and tumorigenesis
Pharmaceutical Sciences
Sharyn D. Baker, PharmD, PhD Clinical pharmacology of tyrosine kinase inhibitors
William E. Evans, PharmD Pharmacogenomics of antileukemic agents in children
Mary V. Relling, PharmD (Dept Chair) Pharmacokinetics and genetics of leukemia therapy
Erin G. Schuetz, PhD Mechanisms of human variation in drug response
John D. Schuetz, PhD Regulation and function of ABC transporters
Alex Sparreboom, PhD Interaction of cancer drugs with solute carriers
Clinton F. Stewart, PharmD Pharmacology of anticancer drugs in children
Jun Yang, PhD Pharmacogenomics of anticancer agents and drug resistance
Heather Conklin, PhD Neuropsychological outcomes in childhood cancer survivors
Valerie Crabtree, PhD Sleep disruptions in children with cancer
Lisa M. Ingerski, PhD Adherence promotion and quality of life outcomes
James L. Klosky, PhD Behavior-based cancer prevention and control
Sean Phipps, PhD (Dept. Chair) Coping and adjustment in children with cancer
Jerlym S. Porter, PhD Transition from pediatric care to adult care in SCD patients; psychosocial factors in health management
Jane E. Schreiber, PhD Neurobehavioral functioning in children with medical disorders
Radiological Sciences
Claudia M. Hillenbrand, PhD Novel MR techniques in solid tumors and sickle cell disease
Sue C. Kaste, DO Skeletal toxicities in childhood cancer survivors
Matthew J. Krasin, MD Developing radiation therapy strategies and toxicity profiles for sarcomas
Larry E. Kun, MD (Dept. Chair) Improving diagnosis and therapy of brain tumors
Thomas E. Merchant, DO, PhD Treatment of CNS tumors and radiation-related CNS effects
Robert J. Ogg, PhD Imaging assessments of brain function in CNS and ocular tumors
Zoltán Patay, MD, PhD Brain tumor characterization by sophisticated quantitative MRI
Wilburn E. Reddick, PhD White matter injury in leukemia and CNS tumors
András Sablauer, MD, PhD Imaging informatics and computerized tumor modeling
Barry L. Shulkin, MD PET imaging and evaluation of pediatric tumors
Scott E. Snyder, PhD Design of radioactive diagnostic agents for functional medical imaging
Weiguang Yao, PhD Proton therapy and cone beam CT
Structural Biology
Donald E. Bashford, PhD Computational molecular biophysics
Eric Enemark, PhD Molecular mechanisms of DNA replication
Richard W. Kriwacki, PhD Structural basis of tumor suppressor function
Tanja Mittag, PhD Dynamic protein complexes in signal transduction
Tudor Moldoveanu, PhD Programmed cell death in health and disease
Junmin Peng, PhD Application of proteomics to ubiquitin biology and human disease
Brenda A. Schulman, PhD Cellular regulation by ubiquitin-like proteins
Stephen W. White, DPhil (Dept Chair) DNA repair, catalysis, and structural-based drug discovery
Andrew M. Davidoff, MD (Dept Chair) Solid tumor surgery, gene therapy, angiogenesis inhibition, neuroblastoma
John A. Sandoval, MD Pediatric surgical oncology, novel therapies for solid tumors
Tumor Cell Biology
Linda M. Hendershot, PhD ER quality control in development and disease
Chunliang Li, PhD Applying genome editing to cancer development
Martine F. Roussel, PhD Genes and microRNAs in brain tumors
Charles J. Sherr, MD, PhD (Dept Chair) Tumor suppressor–dependent signaling networks