Sheri Spunt, MD

Sheri L. Spunt, MD

Member, St. Jude Faculty

Departments

Oncology
Pediatric Medicine

Divisions

Solid Tumor


Education

BAS - Stanford University, Stanford, California
MD - The University of Michigan School of Medicine, Ann Arbor, Michigan
Internship/Residency (Pediatrics) – University of California, Los Angeles, School of Medicine
Fellowship (Pediatric Hematology/Oncology) – Johns Hopkins University School of Medicine


Honors & Awards


Research Interests


Selected Publications

Geoerger B, Kieran MW, Grupp S, Perek D, Clancy J, Krygowski M, Ananthakrishnan R, Boni JP, Berkenblit A, Spunt SL. Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma. Eur J Cancer 48(2):253-62, 2012.

Huh WW, Yuen C, Munsell M, Hayes-Jordan A, Lazar AJ, Patel S, Wang WL, Barahmani N, Okcu MF, Hicks J, Debelenko L, Spunt SL. Liposarcoma in children and young adults: a multi-institutional experience. Pediatr Blood Cancer 57(7):1142-6, 2011.

Spunt SL, Vargas SO, Coffin CM, Skapek SX, Parham DM, Darling J, Hawkins DS, Keller C. The clinical, research, and social value of autopsy after any cancer death: a perspective from the Children's Oncology Group Soft Tissue Sarcoma Committee. Cancer October 17, 2011.

Baker JN, Harper J, Kane JR, Hicks J, Ward D, Hinds PS, Spunt SL. Implementation and evaluation of an automated patient death notification policy at a tertiary pediatric oncology referral center. J Pain Symptom Manage 42(5):652-6, 2011.

Ferrari A, Sultan I, Huang TT, Rodriguez-Galindo C, Shehadeh A, Meazza C, Ness KK, Casanova M, Spunt SL. Soft tissue sarcoma across the age spectrum: a population-based study from the Surveillance Epidemiology and End Results database. Pediatr Blood Cancer 57(6):943-9, 2011.

Spunt SL, Grupp SA, Vik TA, Santana VM, Greenblatt DJ, Clancy J, Berkenblit A, Krygowski M, Ananthakrishnan R, Boni JP, Gilbertson RJ. Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors. J Clin Oncol 29(21):2933-40, 2011.

Rodeberg DA, Stoner JA, Garcia-Henriquez N, Randall RL, Spunt SL, Arndt CA, Kao S, Paidas CN, Million L, Hawkins DS. Tumor volume and patient weight as predictors of outcome in children with intermediate risk rhabdomyosarcoma: a report from the Children's Oncology Group. Cancer 117(11):2541-2550, 2011.

Ferrari A, Miceli R, Rey A, Oberlin O, Orbach D, Brennan B, Mariani L, Carli M, Bisogno G, Cecchetto G, De Salvo GL, Casanova M, Vannoesel MM, Kelsey , Stevens MC, Devidas M, Pappo AS, Spunt SL. Non-metastatic unresected paediatric non-rhabdomyosarcoma soft tissue sarcomas: results of a pooled analysis from United States and European groups. Eur J Cancer 47(5):724-31, 2011.

Saab R, Spunt SL, Skapek SX. Myogenesis and rhabdomyosarcoma: the Jekyll and Hyde of skeletal muscle. Curr Top Dev Biol 94:197-234, 2011.

Spunt SL, Irving H, Frost J, Sender L, Guo M, Yang BB, Dreiling L, Santana VM. Phase II, randomized, open-label study of pegfilgrastim-supported VDC/IE chemotherapy in pediatric sarcoma patients. J Clin Oncol 28(8):1329-36, 2010.

Khoury JD, Coffin CM, Spunt SL, Anderson JR, Meyer WH, Parham DM. Grading of nonrhabdomyosarcoma soft tissue sarcoma in children and adolescents: a comparison of parameters used for the Federation Nationale des Centers de Lutte Contre le Cancer and Pediatric Oncology Group Systems. Cancer Feb. 17, 2010.

Krasin MJ, Davidoff AM, Xiong X, Wu S, Hua CH, Navid F, Rodriguez-Galindo C, Rao BN, Hoth KA, Neel MD, Merchant TE, Kun LE, Spunt SL.Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma. Int J Radiat Oncol Biol Phys 76(3):874-8, 2009.

Navid F, Billups CA, Krasin MJ, Davidoff AM, Harper J, Rao BN, Spunt SL. Body wall and visceral nonrhabdomyosarcoma soft tissue sarcomas in children and adolescents. J Pediatr Surg 44(10):1965-71, 2009.

Klosky JL, Randolph-Frye ME, Navid F, Gamble HL, Spunt SL, Metzger ML, Daw N, Morris EB, Hudson M. Sperm cryopreservation practices among adolescent cancer patients at risk for infertility. Pediatr Hematol Oncol 26:252-60, 2009.

McGregor LM, Spunt SL, Furman WL, Stewart CF, Schaiquevich P, Krailo MD, Speights R, Ivy P, Adamson PC, Blaney SM. Phase I study of oxaliplatin and irinotecan in pediatric patients with refractory solid tumors: A Children’s Oncology Group study. Cancer 115:1765-75, 2009.

Hoffer RA, Daw NC, Xiong X, Anghelescu D, Krasin M, Yan X, Davidoff AM, Furman WL, Rodriguez-Galindo C, Spunt SL. A phase I/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors. Cancer 115(6):1328-37, 2009.

Ritchey M, Ferrer F, Shearer P, Spunt SL. Late effects on the urinary bladder in patients treated for cancer in childhood: A report from the Children’s Oncology Group. Pediatr Blood Cancer 52(4):439-46, 2009.

Deyrup A, Miettinen M, North PE, Khoury JD, Tighiouart M, Spunt SL, Parham DM, Weiss SW, Shehata BM. Angiosarcomas arising in the viscera and soft tissue of children and young adults: A clinicopathologic study of 15 cases. Am J Surg Pathol 33:264-9, 2009.

McGregor LM, Spunt SL, Santana VM, Stewart CF, Ward DA, Watkins A, Laningham FH, Ivy P, Furman WL, Fouladi M. Phase I study of an oxaliplatin-etoposide regimen in pediatric patients with recurrent solid tumors. Cancer 115:655-64, 2009.

Jones DP, Spunt SL, Green D, Springate JE. Renal late effects in patients treated for cancer in childhood: A report from the Children’s Oncology Group. Pediatr Blood Cancer 51:724-31, 2008.

Spunt SL, Skapek SX, Coffin CM. Pediatric non-rhabdomyosarcoma soft tissue sarcomas. Oncologist 13(6):668-78, 2008.

Kurt BA, Armstrong GT, Cash DK, Krasin MJ, Morris EB, Spunt SL, Robison LL, Hudson MM. Primary care management of the childhood cancer survivor. J Pediatr 152:458-66, 2008.

Goodin GS, McCarville MB, Thibodeau SN, Skapek SX, Khoury JD, Spunt SL. Prolactinoma as the first manifestation of Gardner’s syndrome. Pediatr Blood Cancer 50:409-412, 2008.

Gaillard P, Krasin MJ, Laningham FH, Hoffer FS, Davidoff AM, Spunt SL, Smiley L, Skapek SX. Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma. Pediatr Blood Cancer 50:157-60, 2008.

Kaste SC, Ahn H, Liu T, Billups CA, Krasin MJ, Hudson MM, Spunt SL. Bone mineral density deficits in pediatric patients treated for sarcomas. Pediatr Blood Cancer 50(5):1032-8, 2007.

Hill DA, Furman WL, Billups CA, Riedley SE, Cain AM, Rao BN, Pratt CB, Spunt SL. Colorectal carcinoma in childhood and adolescence: A clinicopathologic review. J Clin Oncol 25(36):5808-14, 2007.

Fouladi M, Laningham F, Wu J, O’Shaughnessy MA, Molina K, Broniscer A, Spunt SL, Luckett I, Stewart CF, Houghton PJ, Gilbertson RJ, Furman WL. Phase I study of everolimus in pediatric patients with refractory solid tumors. J Clin Oncol 25:4806-12, 2007.

Harper J, Hinds PS, Baker JN, Hicks J, Spunt SL, Razzouk BI. Creating a palliative and end-of-life program in a cure-oriented pediatric setting: The zig-zag method. J Pediatr Oncol Nurs 24:246-54, 2007.

Rodriguez-Galindo C, Liu T, Krasin MJ, Wu J, Billups CA, Daw NC, Spunt SL, Rao BN, Santana VM, Navid F. Analysis of prognostic factors in Ewing sarcoma family of tumors: Review of St. Jude Children’s Research Hospital studies. Cancer 110:375-84, 2007.

Spunt SL, Freeman BB III, Billups CA, McPherson V, Khan RB, Pratt CB, Stewart CF. A phase I clinical trial of oxaliplatin in children and adolescents with refractory solid tumors. J Clin Oncol 25(16):2274-80, 2007.

Nicol K, Savell V Jr., Moore J, Teot L, Spunt SL, Qualman S. Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: A Children’s Oncology Group study. Pediatr Dev Pathol 10:89-97, 2007.

Krasin MJ, Xiong X, Reddick WE, Ogg RJ, Hoffer FA, McCarville B, Kaste SC, Spunt SL, Navid F, Davidoff AM, Zhang L, Kun LE, Merchant TE. A model for radiation-induced quantitative changes in the magnetic resonance signal characteristics in the muscle of children over time. Magn Reson Imaging 24:1319-24, 2006.

Weiss A, Khoury JD, Kaste SC, Spunt SL. Proceedings of the tumor board of St. Jude Children’s Research Hospital, Memphis, Tennessee: Gestational choriocarcinoma. Pediatr Blood Cancer 47:640-6, 2006.

Spunt SL, Rodriguez-Galindo C, Fuller CE, Harper J, Krasin MJ, Billups CA, Khoury JD. Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer. Cancer 107(1):201-6, 2006.

Navid F, Santana V, Billups CA, Merchant TE, Spunt SL, Cain AM, Rao BN, Hale G, Pappo AS. Concomitant administration of vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VACIE) for high risk sarcomas: The St. Jude Children’s Research Hospital experience. Cancer 106:1846-56, 2006.

Gupta H, Davidoff AM, Rao BN, Jenkins J, Spunt SL. Neonatal epithelioid sarcoma: A distinct clinical entity? J Pediatr Surg 41:9-11, 2006.

Weiss A, Khoury JD, Kaste SC, Spunt SL. Proceedings of the tumor board of St. Jude Children’s Research Hospital, Memphis, Tennessee: Gestational choriocarcinoma. Pediatr Blood Cancer 47:640-646, 2006.

Spunt SL, Pappo AS. Childhood non-rhabdomyosarcoma soft tissue sarcomas are not “adult-type” tumors. J Clin Oncol 24:1958-9, 2006

Krasin MJ, Xiong X, Reddick WE, Ogg RJ, Hoffer FA, McCarville B, Kaste SC, Spunt SL, Navid F, Davidoff AM, Zhang L, Kun LE, Merchant TE. A model for radiation-induced quantitative changes in the magnetic resonance signal characteristics in the muscle of children over time. Magn Reson Imaging 24:1319-24, 2006.

Hinds PS, Drew D, Oakes LS, Fouladi M, Spunt SL, Church C, Furman WL. End-of-life care preferences of pediatric patients with cancer. J Clin Oncol 23:9146-54, 2005.

Spunt SL, Sweeney TA, Hudson MM, Billups CA, Krasin MJ, Hester AL. Late effects of pelvic rhabdomyosarcoma and its treatment in female survivors. J Clin Oncol 23(28):7143-51, 2005.

McCarville MB, Christie R, Daw, NC, Spunt SL, Kaste SC. PET/CT in the evaluation of childhood sarcomas. AJR Am J Roentgenol 184:1293-1304, 2005.

Spunt SL, Smith LM, Ruymann FB, Qualman SJ, Donaldson SS, Rodeberg DA, Anderson JR, Crist WM, Link MP. Cyclophosphamide dose intensification during induction therapy for intermediate-risk pediatric rhabdomyosarcoma is feasible but does not improve outcome: A report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. Clin Cancer Res 10(18):6072-9, 2004.

Sung L, Anderson JR, Donaldson S, Spunt SL, Crist WM, Pappo AS. Late events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: A report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. Eur J Cancer 40:1878-85, 2004.

Spunt SL, Walsh MF, Krasin MJ, Helton KJ, Billups CA, Cain AM, Pappo AS. Brain metastases of malignant germ cell tumors in children and adolescents. Cancer 101:620-6, 2004.

Spunt SL, Hill DA, Motosue AM, Billups CA, Cain AM, Rao BN, Pratt CB, Merchant TE, Pappo AS. Clinical features and outcome of initially unresected nonmetastatic pediatric nonrhabdomyosarcoma soft tissue sarcoma. J Clin Oncol 20(15):3225-35, 2002.

Spunt SL, Anderson JR, Teot LA, Breneman JC, Meyer WH, Pappo AS. Routine brain imaging is unwarranted in asymptomatic patients with rhabdomyosarcoma arising outside of the head and neck region that is metastatic at diagnosis. Cancer 92(1):121-5, 2001.

Spunt SL, McCarville MB, Kun LE, Poquette CA, Cain AM, Brandao L, Pappo AS. Selective use of whole-lung irradiation for patients with Ewing sarcoma family tumors and pulmonary metastases at the time of diagnosis. J Pediatr Hematol Oncol 23(2):93-8, 2001.

Spunt SL, Pratt CB, Rao BN, Pritchard M, Jenkins JJ, Hill DA, Cain AM, Pappo AS. Childhood carcinoid tumors: the St Jude Children's Research Hospital experience. J Pediatr Surg 35(9):1282-6, 2000.

Spunt SL, Lobe TE, Pappo AS, Parham DM, Wharam MD, Arndt C, Anderson JR, Crist WM, Paidas C, Wiener E, Andrassy RJ, Schwartz CL. Aggressive surgery is unwarranted for biliary tract rhabdomyosarcoma. J Pediatr Surg 35(2):309-16, 2000.

Spunt SL, Poquette CA, Hurt YS, Cain AM, Rao BN, Merchant TE, Jenkins JJ, Santana VM, Pratt CB, Pappo AS. Prognostic factors for children and adolescents with surgically resected nonrhabdomyosarcoma soft tissue sarcoma: an analysis of 121 patients treated at St Jude Children's Research Hospital. Journal of Clinical Oncology 17(12):3697-705, 1999.

Last update: January 2012