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Leukemias / Lymphomas : Relapsed or refractory B-precursor acute lymphoblastic leukemia
This research is focused on patients who have acute lymphocytic leukemia (ALL) that has come back after treatment (relapsed) or did not respond to treatment (refractory). There are about 4,000 new cases of ALL in the United States each year. It appears most often in children younger than age 10. ALL is the most common leukemia in children. Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of the white blood cells. Lymphocytes are a type of white blood cell that the body uses to fight infections. In ALL, the bone marrow makes lots of unformed cells called blasts that normally would develop into lymphocytes. However, the blasts are abnormal. They do not develop and cannot fight infections. The number of abnormal cells (or leukemia cells) grows quickly. They crowd out the normal red blood cells, white blood cells and platelets the body needs.
This is a research study of MT103 (blinatumomab, or study drug) for the treatment of Acute Lymphoblastic Leukemia (ALL) in children and adolescents. The study drug is experimental, which means that this drug has not yet been approved by any authority that regulates new medicines, including the United States (US) Food and Drug Administration (FDA).
This study has two phases. Phase I is tested for different doses of study drug in two age groups (two to six years and seven to 18 years of age) to find the recommended dose for children and adolescents in these age groups. Phase II of the study will test the dose selected in the Phase I part of the study in these same age groups. Children less than 2 years of age will also be included in the Phase II of the study (not included in Phase I).
In phase II of this research study, the main objectives are:
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Sima Jeha, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-866-2ST-JUDE (1-866-278-5833)
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.