Paul Taylor

    J. Paul Taylor, MD, PhD

    Member, St. Jude Faculty
    Chair, Cell & Molecular Biology
    Edward F. Barry Endowed Chair in Cell and Molecular Biology

    Departments

    Cell & Molecular Biology

    Contact Information

    J. Paul Taylor, MD, PhD
    Cell & Molecular Biology
    MS 343, D-4026
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: jpaul.taylor@stjude.org
    Phone: (901) 595-6047
    FAX: (901) 595-5947

    Education

    MD PhD - Jefferson Medical College, Philadelphia, Pennsylvania
    Neurology Residency – Hospital of the University of Pennsylvania
    Neurogenetics Fellowship – Neurogenetics Branch, NINDS/NIH


    Honors & Awards


    Research Interests

    The principal goal of our research is to reduce the morbidity and mortality associated with neurological disease. Toward this end we:


    Selected Publications

    2014 Publications

    Taylor JP. G-quadruplex poses a quadruple threat. Nature 2014 (in press).

    Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T and Taylor JP. Microtubule-dependent transport of TDP-43 mRNA granules in neurons is impaired by ALS-causing mutations. Neuron 81(3):536-543, 2014.

    Seleen M, Visser AE, Overste DJ, Kim HJ, Palud A,Wong TH, van der Flier WM, van Swieten JC, Scheltens P, Voermans NC, Baas F, de Jong JMBV, van der Kooi AJ, de Visser M, Veldink JH, Taylor JP, Van Es MA and van den Berg LH. No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia and inclusion body myositis. Neurobiol Aging 2014 (in press).

    Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, ITALSGEN23, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neurosci 2014 (in press).

    2013 Publications

    Ramaswami M†, Taylor JP†, Parker R†. Altered "Ribostasis": RNA-protein granule formation or persistence in the development of degenerative disorders. Cell 154(4):727-36, 2013. †co-corresponding authors

    Buchan JR*, Kolaitis R*, Taylor JP† and Parker R†. Eukaryotic stress granules are cleared by granulophagy and Cdc48/VCP function. Cell 153(7):1461-74, 2013. *co-first authors, †co-corresponding authors

    Kim HJ, Kim NC, Wang M, Scarborough EA, Moore J, Diaz Z, Maclea K, Freibaum B, Molliex A, Kanagaraj A, Li S, Pinkus JL, Greenberg SA, Trojanowski J, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Wojtas AM, Boylan KB, Rademakers R, Kottlors M, Kirschner J, Li YR, Gitler AD, Benatar M, King OD, Kimonis V, Ross ED, Weihl CC, Shorter J, Taylor JP. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 495:467-473, 2013.

    Shorter J, Taylor JP. Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2B1 introduce potent steric zippers that drive excess RNP granule assembly. Rare Diseases http://dx.doi.org/10.4161/rdis.25200, 2013.

    Taylor JP. RNA Gets RAN in Neurodegeneration Science 339:1282-1283, 2013.

    Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas R, Alami N, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP. VCP is essential for mitochondrial quality control by the PINK1/Parkin pathway and this function is impaired by disease-causing mutations. Neuron 78:65-80, 2013.

    Benatar M, Weihl CC, Wuu J, Traynor B, Oskarsson B, Fernandez C, Taylor JP. Motor neuron involvement in multisystem proteinopathy: implications for ALS. Neurology 80(20):1874-1880, 2013.

    Fujita K, Nakamura Y, Oka T, Ito H, Tarrua T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsana M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA damage repair in multiple polyglutamine diseases. Nature Communications 4:1816, 2013. doi: 10.1038/ncomms2828.

    Todd PK, Oh SY, Krans A, He F, Sellier C, Frazer M, Renoux AJ, Chen KC, Scaglione M, Basrur V, Elenitoba-Johnson K, Vonsattel JP, Louis ED, Sutton MA, Taylor JP, Mills RE, Charlet-Berguerand N, and Paulson HL. CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome. Neuron 78(3):440-455, 2013.

    2012 Publications

    Gao FB, Taylor JP. RNA-binding proteins in neurological disease. Brain Research 1462:1-2. 2012.

    Usenovic M, Tresse E, Taylor JP, Krainc D. Parkinsonism-linked ATP13A2 causes lysosomal dysfunction and α-synuclein accumulation. J Neurosci 32(12):4240-6. 2012.

    Messing A, Li R, Naidu S, Taylor JP, van der Knaap MS, Flint D, Brenner M. Novel GFAP mutations in two archetypical Alexander disease families. Archives of Neurology 69(2):208-14. 2012.

    Klionsky et al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445-544, 2012.

    Abramzon Y, Johnson JO, Scholz SW, Taylor JP, Brunnetti M, Calvo A, Mandrioli J, Benatar M, Mora G, Restagno G, Chio A and Traynor BJ. Valosin-containing protein mutations in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging 33(9):2231.e1-2231.e6. 2012.

    Park YN, Zhao X, Norton M, Taylor JP, Eisenberg E and Greene LE. Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell. PloS One 7(6):e40329, 2012.

    2011 Publications

    Smith RB, Taylor JP. Dissection and staining of active zones in the Drosophila neuromuscular junction. Journal of Visualized Experiments http://www.jove.com/video/2676/dissection-imaging-active-zones-drosophila-neuromuscular 2011.

    Lanson N, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE and Pandey UB. A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. Human Molecular Genetics 20(13):2510-23, 2011.

    Majounie E, Traynor BT, Chio A, Restagno G, Benatar M, Taylor JP, Singleton AB. Mutational analysis of the VCP gene in Parkinson’s disease. Neurobiology of Aging 33(1): 209 2011.

    Mammen, AL, Mahoney JA, St. Germain A, Badders N, Taylor JP, Rosen A, and Spinette S. A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B is Expressed Exclusively in Mature Striated Muscle Cells. PloS One 6(12):e28861, 2011.

     

    Sample publications 2010 or earlier

    Last update: February 2014