Richard J. Gilbertson, MD, PhD

    Richard J. Gilbertson, MD, PhD

    Member, St. Jude Faculty
    Director, Comprehensive Cancer Center and EVP
    Director, Division of Brain Tumor Research
    Lillian R. Cannon Comprehensive Cancer Center Director Endowed Chair

    Departments

    Developmental Neurobiology
    Oncology

    Contact Information

    Richard Gilbertson, MD, PhD
    Developmental Neurobiology
    Room D2006G
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: richard.gilbertson@stjude.org
    Phone: (901) 595-5935
    FAX: (901) 595-8600

    Research Interests

    The principal aim of my research is to reduce the morbidity and mortality of children with central nervous system tumors through improved understanding of tumor biology. We hope to achieve this goal by:


    Selected Publications

    Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li X, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksford J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL,. Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma. Nature 2014 (in press).

    Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Beckford J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature 488:43-48, 2012.

    Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21:168-80, 2012.

    Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold A, Wright KD, Johnson RA, Poppleton H, Mohankumar KM, Feau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WKA, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high throughput screen identifies treatment leads for ependymoma. Cancer Cell 20:384-99, 2011.

    Gilbertson RJ. Mapping Cancer Origins. Cell 145 :25-9, 2011.

    Gibson P, Tong, Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang Z-J, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095-9. 2010.

    Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein DF, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang M, Coyle B, Atkinson J, DeWire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison DW, Taylor MD, Grundy RG, Gilbertson RJ. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466: 632–636, 2010.

    Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457:603-7, 2009.

    Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber W, Finklestein D, Allen M, Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A, Gilbertson RJ. A Perivascular niche for brain tumor stem cells. Cancer Cell 11:69-82, 2007.

    Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdelano S, Dalton J, Board J, MacDonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial Glia cells are candidate stem cells of ependymoma. Cancer Cell 8:323-335, 2005.

    Last update: January 2014