Related Topics
 

Roussel: Complete List of Publications



Zhao M, Gupta V, Raj L, Roussel MF and Bei M. A network of transcription factors operates during tooth morphogenesis. Mol Cell Biol 33:3099-3112, 2013. PMID: 23754753. PMICD: PMC3753897.

Gebhardt A, Wolf E, Kawauchi D, Walz S, Renninger C, von Eyss B, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M. Miz1 is required to maintain physiological levels of autophagy flux. Nature Communications 2013 (in press).

Anne SL, Ayrault O, Kim JH, Govek E-E, Van Aelst L, Roussel MF, Hatten M-B. Wnt3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation. PLoS One 2013 (in press).

Roussel MF, Robinson GW. Role of MYC in Medulloblastoma. Cold Spring Harbor Lab Perspect Med. DOI: 10.1101/CSHPERSPECT/014308. 2013 (in press).

Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zheng F-Y, Shelat AA, Guy K, Taylor MR, Chen T, Roussel MF. Identification of small molecule activators of BMP signaling. PLoS One 8: e59045, 2013.

Northcott PA, Shih DJ, Peacock J, Garzia L, Sorana Morrissy A, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Ming Nip K, Qian JQ, Raymond AG, Thiessen N, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Yancey Gillespie G, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Shin Ra Y, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD. Nature Jul 25, 2012. [Epub ahead of print] PMID: 22832581

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature June 20, 2012.

Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel MF, Zuo J. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by atoh1 ectopic expression. J Neurosci 32(19):6600-10, 2012.

Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Cell Death Dis 3:e308, 2012.

Kawauchi D, Robinson G, Uziel T, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. A mouse model of the most aggressive subtype of human medulloblastoma. Cancer Cell, 21(2):168-80, 2012.

Gil-Perotin S, Haines JD, Kaur J, Marin-Husstege M, Spinetta MJ, Kim KH, Duran-Moreno M, Schallert T, Zindy F, Roussel MF, Garcia-Verdugo JM, Casaccia P. Roles of p53 and p27 (Kip1) in the regulation of neurogenesis in the murine adult subventricular zone. Eur J Neurosci 34(7):1040-52, 2011.

Roussel MF. p27 (Kip1) enforces maintenance of quiescence in the mammalian ear and the pituitary gland. Cell Cycle 10(16):2617-8, 2011.

Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy KR, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Stewart CF. Whole body physiologically-based pharmacokinetic model for nutlin-3a after intravenous and oral administration. Drug Metabolism and Disposition 39(1):15-21, 2011.

Wang Y, Fisher JC, Mathew R, Qu L, Otieno S, Sublett J, Xiao L, Jianhan C, Roussel MF, Kriwacki RW. Intrinsic Disorder Mediates the Diverse Cell Cycle Regulatory Functions of the Cyclin-Dependent Kinase Inhibitor, p21Cip1. Nature Chem Biol Feb 27, 2011.

Roussel MF, Hatten ME. Cerebellum development and medulloblastoma. Curr Top Dev Bio 94:235-282, 2011.

Hatten ME, Roussel, MF. Development and Cancer of the Cerebellum.  Trends in Neurosciences, Elsevier Press 2010 (in press).

Trikha P, Sharma N, Opavsky R, Reyes A, Pena C, Ostrowski M, Roussel MF, Leone G. E2f1-3 are critical for myeloid development. J Biol Chem 286(6):4783-95, 2011.

Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy KR, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Stewart CF. Whole body physiologically-based pharmacokinetic model for nutlin-3a after intravenous and oral administration. Drug Metabolism and Disposition 2010 Oct 14. Epub ahead of print PMID: 20947617.

Gibson P, Tong Y, Robinson G, Thompson M, Currle D.S., Eden C, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Patay Z, Scoggins M, Ogg R, Pei Y, Brun S, Zindy F, Lindsey JC, Gutmann DH, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Taketo MM, Ellison DW, Wechsler-Reya R, Gilbertson RJ. Subtypes of medulloblastoma have distinct developmental origins. Nature 468(7327):1095-1099, 2010.

Roussel MF. New concepts in organ site research on medulloblastoma: genetics and genomics. Future Oncol 6(8):1229-1231, 2010.

Ayrault O, Zhao H, Zindy F, Qu C, Sherr CJ, Roussel MF. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Res 70:5618-5627, 2010. PMID: 20516124.

Ayrault O*, Godeny MD, Dillon C, Zindy F, Fitzgerald P, Roussel MF, Beere H. Inhibition of Hsp90 via 17-DMAG Induces Apoptosis in a p53-Dependent Manner to Prevent Medulloblastoma. Proc Natl Acad Sci, USA 106:17037-17042, 2009.

Ayrault O*, Zindy F*, Regh J, Sherr CJ, Roussel MF. Two tumor suppressors, p27Kip1 and Patched 1 collaborate to prevent medulloblastoma. Mol Cancer Res Jan;7(1):33-40, 2009.

Huang DT, Ayrault O, Hunt HW, Taherbhoy AM, Duda DM, Scott DC, Borg LA, Neale G, Murray PJ, Roussel MF, Schulman BA. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell Feb 27;33(4):483-95, 2009.

Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF. The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.  Proc Natl Acad Sci USA Feb 24:106(8):2812-7, 2009.

Forget A, Ayrault O, den Besten W, Kuo M-L, Sherr CJ, Roussel MF. Differential post-transcriptional regulation of two Ink4 proteins, p18Ink4c and p19Ink4d. Cell Cycle 7(23):3737-46, 2008.

Ayrault O*, Zindy F*, Regh J, Sherr CJ, Roussel MF. Two tumor suppressors, p27Kip1 and Patched 1 collaborate to prevent medulloblastoma. Mol Cancer Res 7(1):33-40, 2009.

Souffron J, Waddell M, Paydar A, Tokgoz Z, Roussel MF, Schulman B. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8’s E1. Biochemistry 47(34): 8961-9, 2008.

Reilly KM, Rubin JB, Gilbertson RJ, Garbow JR, Roussel MF, Gutmann DH Rethinking brain tumors: the fourth mouse models of human cancers consortium nervous system tumors workshop. Cancer Res 68(14): 5508-11, 2008.

Zhao H*, Ayrault A*, Zindy F, Kim J-H, Roussel MF.  Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev 22(6):722-7, 2008.

Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Knoepfler PS, Eisenman RN, Roussel MF, Dyer MA. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev 22(2):179-93, 2008.

Ayrault O, Zindy F, Roussel MF.  TP53 and RB tumor suppressor pathways collaborate in retinoblastoma genesis.  Med Sci (Paris) 23(4):356-8, 2007.

Zindy F*, Uziel T*, Ayrault O, Calabrese C, Valentine M, Rehg G, Gilbertson R, Sherr CJ, Roussel MF.  Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67(6):2676-84, 2007.

Nilsson LM, Keller UB, Yang C-Y, Nilsson JA, Cleveland JL, Roussel MF. Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis. Oncogene 26(20):2833-9, 2007.

Sherr CJ, Bertwistle D, Den Besten W, Kuo ML, Sugimoto M, Tago K, Williams RT, Zindy F, Roussel MF. p53-Dependent and –independent functions of the Arf tumor suppressor. ColdSpring HarborLaboratories 70, 129-137, 2006.

Roussel MF.  Tumor Suppressors.   Chapter 7 in Molecular Biology of Cancer. Editors, Pelengaris and Khan, Blackwell Ltd, pp 219-150, 2006.

Uziel T, Zindy F, Sherr CJ, Roussel MF. The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma. Cell Cycle 5(4):363-5, 2006.

Zindy F, Knoepfler P, Xie S, Sherr CJ, Eisenman R, Roussel MFN-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.  Proc Natl Acad Sci 103(31):11579-83, 2006.

Williams RT, Roussel MF, Sherr CJ.  Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl induced acute lymphoblastic leukemia. Proc Natl Acad Sci USA103:6688-6693, 2006.

Gil-Perotin S, Marin-Husstege M, Li J, Soriano-Navarro M, Zindy F Roussel MF,Garcia-Verdugo JM,Casaccia-Bonnefil P.  Loss of p53 induces changes in the behavior of SVZ cells:  implication for the genesis of glial tumors. J Neurosci 26(4):1107-16, 2006.

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME,  McKinnon  PJ, , Gilbertson RJ, Curran T, Sherr CJ, Roussel MF.  The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 19(22):2656-67, 2005.

Kuo M-L, den Besten W, Bertwistle D, Roussel MF, Sherr CJ. N-Terminal Multi-Ubiquitination and Degradation of the Arf Tumor Suppressor. Genes and Dev 18:1862-1874, 2004.

Bertwistle D, Zindy F, Sherr CJ, Roussel MF. Monoclonal antibodies to the mouse p19(Arf) tumor suppressor protein. Hybrid Hybridomics 23(5):293-300, 2004.

Huang DT, Miller DW, Mathew R, Cassell R, Holton JM, Roussel MF, Schulman BA. A unique E1-E2 interaction  required for optimal conjugation of the ubiquitin-like protein NEDD8. Nat Struct Mol
Biol
11:927-35, 2004. PMID: 15361859.

Yokota Y, Matsuzaki Y, Miyazawa K, Zindy F, Roussel MF, Sakai T. Histone deacetylase inhibitors
activate INK4d gene through Sp1 site in its promoter. Oncogene 23:5340-9, 2004. 

Cheng C, Pounds SB, Boyett JM, Pei D, Kuo M-L, Roussel MF.  Statistical significance threshold criteria for analysis of microarray gene expression data. Statistical Applications in Genetics and Molecular Biology 3, 1-30, 2004.

Wrobel CN, Debnath J, Beausoleil S, Lin E, Roussel MF, Brugge JS. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biology 165:263-273, 2004.

Zindy F, Williams RT, Baudino TA, Rehg JE, Skapek SX, Cleveland JL, Roussel MF, Sherr CJ. Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.  Proc Natl Acad Sci USA 100:15930-15935, 2003. PMID: 14665695

Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne RJ, Regh JE, Eberhart C, Sherr CJ, Roussel MF. Hemangiosarcomas, Medulloblastomas, and Other Tumors in Ink4c/p53-Null Mice. Cancer Res 63:5420-5427, 2003. PMID: 14500377

Lee Y, Miller H, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel MF, Curran T, Gilbertson R,  McKinnon PJ. A Molecular Fingerprint for Medulloblastoma. Cancer Res 63:5428-5437, 2003. PMID: 14500378

Kuo M-L, Duncavage EJ, Mathew R, den Besten W, Pei D, Naeve D, Yamamoto T, Cheng C, Sherr CJ, Roussel MF.  Arf induces p53-dependent and independent anti-proliferative genes. Cancer Res 63:1046-1053, 2003. PMID: 12615721

Sugimoto M, Kuo M-L, Roussel MF, Sherr CJ. Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing. Mol Cell 11:415-424, 2003. PMID: 12620229

Baudino TA, MacLean KH, Brennan J, Parganas E, Yang C, Aslanian A, Lees JA, Sherr CJ, Roussel MF, Cleveland JL. Myc-mediated proliferation and lymphomatogenesis, but not apoptosis, are compromised by E2f1 loss. Mol Cell 11:905-914, 2003. PMID: 12718877

Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N.  Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol 5:422-426, 2003. PMID: 12717441

Lowe SW, Sherr CJ. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev 13:77-83, 2003. PMID: 12573439

Sherr CJ, McCormick F. The Rb and p53 pathways in cancer. Cancer Cell 2: 103-112, 2002.  PMID: 12204530

Inoue K, Zindy F, Randle DH, Rehg JE, Sherr CJ. Dmp1 is haplo-insufficient for tumor suppression and  modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev 15:2934-2939, 2001.  PMID: 11711428

Randle DH, Zindy F, Sherr CJ, Roussel MF. Differential effects of p19ARF and p16INK4a loss on senescence of murine bone marrow-derived pre-B cells and macrophages. Proc Natl Acad Sci USA 98: 9654-9659, 2001.  PMID: 11481442

Sherr, CJ. The INK4a/ARF network in tumour suppression.  Nature Rev Mol Cell Biol 2: 731-737, 2001.  PMID: 11584300

Zindy F, den Besten W, Chen B, Rehg JE, Latres E, Barbacid M, Pollard J, Sherr CJ, Cohen PE, Roussel MF. Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18Ink4c and p19Ink4d. Mol Cell Biol 21:3244-3255, 2001.  PMID: 11287627

Cunningham JJ, Roussel MF. Cyclin-dependent kinase inhibitors in the development of the central nervous system.  Cell Growth & Diff 8:387-396, 2001.  PMID: 11504704

Inoue K, Wen R, Rehg JE, Adachi M, Cleveland JL, Roussel MF, Sherr CJ. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes Dev 14:1797-1809, 2000.  PMID: 10898794

Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell 102:407-410, 2000.  PMID: 10966103

Weber JD, Jeffers JR, Rehg JE, Randle DH, Lozano G, Roussel MF, Sherr CJ,  Zambetti GP.  p53-Independent functions of the p19ARF tumor suppressor.  Genes & Dev 14:2358-2365, 2000.  PMID: 10995391

Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1 phase progression. Genes Dev 13:1501-1512, 1999.  PMID: 10385618

Cheng M, Oliver P, Diehl JA, Fero M, Randle DH, Roberts JM, Roussel MF, Sherr CJ. The p21CIP1 and p27KIP1 CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18: 1571-1583, 1999.  PMID: 10075928

Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL.  Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.  Genes Dev 13:2658-2669, 1999.  PMID: 10541552

Zindy F, Cunningham JJ,  Sherr CJ, Jogal S,  Smeyne RJ, Roussel MF. Postnatal neuronal proliferation in INK4d-KIP1 null mice.  Proc Natl Acad Sci USA 96:13462-13467, 1999.  PMID: 10557343

Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D. Nucleolar ARF sequesters Mdm2. Nat Cell Biol 1:20-26, 1999.  PMID: 10559859

Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3B regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499-3511, 1998.  PMID: 9832503

Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF.  Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 12:2424-2433, 1998.  PMID: 9694806

Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ. Functional and physical interactions of the ARF tumor suppressor with p53 and mdm2. Proc Natl Acad Sci USA 95:8292-8297, 1998.  PMID: 9653180

Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91:649-59, 1997.  PMID: 9393858

Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ. Novel INK4 proteins, p18 and p19: Specific inhibitors of cyclin D-dependent kinases, cdk4 and cdk6. Mol Cell Biol 10:1229-34, 1995.  PMID: 7739547

Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993-1000, 1995.

Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, Sherr CJ. Identification and properties of an atypical catalytic subunit (p34PSK-J3/Cdk4) for mammalian D-type G1 cyclins. Cell 71:323-34, 1992.  PMID: 1423597

Matsushime H, Roussel MF, Ashumn RA, Sherr CJ. Colony-stimulating factor-1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701-13, 1991.  PMID: 1827757


Last
update: September 2013