Deepa Bhojwani, MD

    Deepa Bhojwani, MD

    Assistant Member, St. Jude Faculty

    Departments

    Oncology

    Divisions

    Leukemia / Lymphoma

    Contact Information

    Deepa Bhojwani, MD
    Oncology
    MS 260, Room C6075
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: deepa.bhojwani@stjude.org
    Phone: (901) 595-3519
    FAX: (901) 521-9005

    Education

    MB, BS – M.S. Ramaiah Medical College, Bangalore, India (1993)
    DCH (MD) – Kasturba Hospital, Manipal, India (1996)


    Research Interests


    Selected Publications

    Wey S, Luo B, Tseng CC, Ni M, Zhou H, Fu Y, Bhojwani D, Carroll WL, Lee AS. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood Jan;119(3):817-25, 2012. PMCID: PMC3265205

    Hogan LE, Meyer JA, Yang J, Wang J, Wong N, Yang W, Condos G, Hunger SP, Raetz E, Saffery R, Relling MV, Bhojwani D, Morrison DJ, Carroll WL. Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood Nov;118(19):5218-26, 2011. PMCID: PMC3217405

    Inaba H, Bhojwani D, Pauley JL, Pei D, Cheng C, Metzger ML, Howard SC, Rubnitz JE, Sandlund JT, Ribeiro RC, Leung W, Campana D, Pui CH, Jeha S. Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies. British Journal of Haematology Jan;156(2):275-9, 2012. PMCID: PMC3235268.

    Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Raimondi SC, Shurtleff S, Onciu M, Cheng C, Coustan-Smith E, Bowman WP, Howard SC, Metzger ML, Inaba H, Leung W, Evans WE, Campana D, Relling MV, Pui CH. ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia Aug 26, 2011. PMCID: PMC3345278

    Inaba H, Bhojwani D, Pauley JL, Pei D, Cheng C, Metzger ML, Howard SC, Rubnitz JE, Sandlund JT, Ribeiro RC, Leung W, Campana D, Pui CH, Jeha S. Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies. British Journal of Haematology Aug 25, 2011 (epub).

    Morrison DJ, Hogan LE, Condos G, Bhatla T, Germino N, Moskowitz NP, Lee L, Bhojwani D, Horton TM, Belitskaya-Levy I, Greenberger LM, Horak ID, Grupp SA, Teachey DT, Raetz EA, Carroll WL. Endogenous knockdown of surviving improves chemotherapeutic response in ALL models. Leukemia Aug 16, 2011 (epub).

    Loudin MG, Wang J, Leung HE, Gurusiddappa S, Meyer J, Condos G, Morrison D, Tsimelzon A, Devidas M, Heerema NA, Carroll AJ, Plon SE, Hunger SP, Basso G, Pession A, Bhojwani D, Carroll WL, Rabin K. Genomic profiling of Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles. Leukemia Jun 7, 2011 (epub).

    Wey S., Luo B., Tseng CC, Ni M, Zhou H, Fu Y, Bhojwani D, Carroll WL, Lee AS. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood Sept 21, 2011 (epub).

    Hogan LE, Meyer JA, Yang J, Wang J, Wong N, Yang W, Condos G, Hunger SP, Raetz E, Saffery R, Relling MV, Bhojwani D, Morrison DJ, Carroll WL. Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood Sept 14, 2011 (epub).

    Brennan R, Pei D, Cheng C, Inaba H, Metzger ML, Howard SC, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Bhojwani D. Spinal epidural lipomatosis in children with hematologic malignancies. Annals of Hematology Sept; 90(9):1067-74, 2011.

    Pui CH, Campana D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Coustan-Smith E, Jeha S, Cheng C, Metzger ML, Bhojwani D, Inaba H, Raimondi SC, Onciu M, Howard SC, Leung W, Downing JR, Evans WE, Relling MV. Improved prognosis of adolescents with acute lymphoblastic leukemia. Journal of Clinical Oncology Feb 1; 29(4):386-91, 2011.

    Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, Chen IM, Atlas SR, Kang H, Ar K, Wilson CS, Wharton W, Murphy M, Devidas M, Carroll AJ, Borowitz MJ, Downing JR., Relling M, Yang J, Bhojwani D, Carroll WL, Camitta B, Reaman GH, Smith M, Hunger SP, Willman CL. Identification of novel cluster groups in pediatric high-risk B-precursor acite lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics and outcome. Blood Dec 2; 116(23):4874-84, 2010.

    Mussai F, Campana D, Bhojwani D, Stetler-Stevenson M, Steinberg SM, Wayne AS, Pastan I. Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against pediatric acute lymphoblastic leukemia. British Journal of Haematology Aug; 150(3):352-8, 2010.

    Pui CH, Pei D, Sandlund JT, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Campana D, Kun LE, Jeha S, Cheng C, Howard SC, Metzger ML, Bhojwani D, Downing JR, Evans WE, Relling MV. Long-term results of St Jude Total Therapy Studies 11, 12, 12A, 13B and 14 for childhood acute lymphoblastic leukemia. Leukemia Feb; 24(2): 371-82, 2010.

    Kang H, Chen IM, Wilson CS, Bedrick EJ, Harvey RC, Atlas SR, Devidas M, Mullighan CG, Wang X, Murphy M, Ar K, Wharton W, Borowitz MJ, Bowman WP, Bhojwani D, Carroll WL, Camitta BM, Reaman GH, Smith MA, Downing JR, Hunger SP, Willman CL. Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood Feb 18;115(7): 1394-405, 2010.

    Gaur AH, Bagga B, Barman S, Hayden R, Lamptey A, Hoffman JM, Bhojwani D, Flynn PM, Tuonamen E, Webby R. Intravenous Zanamivir for Oseltamivir-resistant 2009 h1N1 influenza. NEJM Jan 7;362(1):88-9, 2010.

    Bhojwani D, Pui CH. Genome-wide studies in childhood acute lymphoblastic leukemia. US Hematology 2009 (in press).

    Bhojwani D, Howard SC, Pui CH. High-risk childhood acute lymphoblastic leukemia. Clinical Lymphoma and Myeloma 2009 (in press).

    Yang JJ, Bhojwani D, Yang W, Cai X, Stocco G, Crews K, Wang J, Morrison D, Devidas M, Hunger SP, Willman CL, Raetz EA, Pui CH, Evans WE, Relling MV, Carroll WL. Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood Nov 15; 112(10): 4178-83, 2008.

    Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz N, Min DJ, Potter J, Harvey R, Hunger SP, Seibel N, Raetz E, Pieters R, Relling MV, Den Boer ML, Willman CL, Carroll WL. Gene expression signatures predictive of early response and outcome in High-risk Childhood Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study: JCO Sept 20; 26(27):4376-4384, 2008.

    Bhojwani D, Pui CH. Intrathecal liposomal cytarabine: More friend than foe? Leukemia Lymphoma 49(8):1427-30, 2008.

    Bhojwani D, Moskowitz N, Raetz E, Carroll WL. The Potential of Gene Expression Profiling in the management of Childhood ALL. Pediatric Drugs 9(3): 149-156, 2007.

    Bhojwani D, Ratez EA, Carroll WL. What has molecular profiling taught us about Childhood ALL? American Society of Clinical Oncology Education Book, 602-605, 2007.

    Bhojwani D, Kang H, Moskowitz M, Min DJ, Lee H, Potter J, Davidson G, Willman C, Borowitz M, Belitskaya-Levy I, Hunger SP, Raetz E, Carroll WL. Biological Pathways Associated with relapse in Childhood Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study. Blood Jul 15; 108(2):711-717, 2006.

    Carroll W, Bhojwani D, Min DJ, Moskowitz N, Raetz E. Childhood Acute Lymphoblastic Leukemia in the Age of Genomics. Pediatric Blood and Cancer May 1; 46(5):570-578, 2006.

    Carroll W, Moskowitz M, Raetz E, Bhojwani D. The Biology of Relapsed Acute Lymphoblastic Leukemia. American Society of Clinical Oncology Education Book, 902-907, 2005.

    Raetz E, Perkins S, Bhojwani D, Philip M, Carroll W, Min DJ. Gene Expression Profiling reveals intrinsic differences between T-cell Acute Lymphoblastic Leukemia and T-cell Lymphoblastic Lymphoma. Pediatric Blood and Cancer Aug; 47(2):130-140, 2005.

    Raetz E, Bhojwani D, Min DJ, Carroll W. Individualized therapy for Childhood acute lymphoblastic Leukemia. Personalized Medicine November, Vol 2, No. 4, 349-361, 2005.

    Bhojwani D, Hart D. Thrombophilia in Childhood. Curr Probl Pediatr Adolesc Health Care May-Jun;34(5):190-212, 2004.

    Bhojwani D, Min DJ, Raetz E, Carroll W. New Approaches to Risk- Adapted Therapy for Childhood Acute Lymphoblastic Leukemia, Hematology. Am Soc Hematol Educ Program 102-08, 2003.

    Last updated: February 2013