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Researchers have identified a protein that offers a new focus for developing targeted therapies to tame the severe inflammation associated with multiple sclerosis, colitis and other autoimmune disorders.
Results of the St. Jude Children’s Research Hospital-led study provide a target for developing novel therapies to tame the inflammation that drives autoinflammatory diseases. (Thirumala-Devi Kanneganti, PhD)
St. Jude Children’s Research Hospital scientists have discovered major “switches” that activate the immune system to kill the bacterium, potentially leading to protective drugs and vaccines. (Thirumala-Devi Kanneganti, PhD)
Researchers like to ask basic questions about how the world and the things in it work. Answers to those questions can advance science and protect health.
St. Jude Children’s Research Hospital scientists report results that suggest neutralizing a single protein may aid fight against a parasitic tropical disease that annually sickens more than 1.3 million people worldwide. (Thirumala-Devi Kanneganti, PhD)
Thirumala-Devi Kanneganti, Ph.D., of St. Jude Children’s Research Hospital, is recognized by the American Association of Immunologists for outstanding research contributions to the field of immunology. (Thirumala-Devi Kanneganti, PhD)
St. Jude Children’s Research Hospital study finds diet may influence susceptibility to autoinflammatory disease in at-risk individuals by favoring intestinal bacteria that fuel or dampen inflammation. (Thirumala-Devi Kanneganti, PhD)
St. Jude Children’s Research Hospital study yields clues for designing next-generation drugs to treat autoinflammatory diseases. (Dr. Kanneganti)
Studies led by St. Jude Children’s Research Hospital show that a protein working on the frontlines of the immune response dampens inflammation and might offer a completely new approach to fighting bacterial infections. (Dr. Thirumala-Devi Kanneganti)
Imagine realizing that a trusted security guard has burglarized your house. A similar discovery in the lab may help researchers identify novel treatments for multiple sclerosis.
Scientists report a protein made by a gene already associated with a handful of human inflammatory immune diseases plays a pivotal role in protecting the intestinal tract from colitis.
One of the most threatening complications of influenza stems not from the virus itself, but from the overreaction of the immune system. This overreaction can cause persistent lung inflammation that lasts long after the virus has been quelled.