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Whole exome sequencing of 20 pediatric ALL patients yielded important insights into the genetic basis of ALL treatment failure. The findings may lead to early detection of the mutations that drive ALL relapse. (Jinghui Zhang, PhD, and Charles G. Mullighan, MBBS(Hons), MSc, MD)
St. Jude scientists identify key molecular events in pediatric adrenocortical tumors. The findings could help clinicians identify most malignant subtypes and lead to better treatment.
Scientists at St. Jude Children’s Research Hospital have more evidence that age matters when it comes to the devastating brain tumors called high-grade gliomas (HGGs).
St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high-grade glioma brain tumors; particularly youngest patients. (Suzanne Baker, PhD, and Jinghui Zhang, PhD)
St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project finds TP53 gene is altered in nearly all osteosarcomas; results help explain how tumors withstand radiation therapy. (Michael Dyer, PhD, and Jinghui Zhang, PhD)
St. Jude Children’s Research Hospital -Washington University Pediatric Cancer Genome Project identifies the most common genetic alteration yet in the brain tumor ependymoma; results offer clues for fighting other cancers. (Richard Gilbertson, MD, PhD, David Ellison, MD, PhD, Jinghui Zhang, PhD)
A hunt through billions of pieces of genetic information uncovers new clues on treatments for childhood ependymoma.
Scientists unearth genes driving a childhood brain tumor.
The Pediatric Cancer Genome Project uncovers the genetic mutations that give rise to cancer.
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project takes new approach to measuring the repetitive DNA at the end of chromosomes and opens new window on mechanisms fueling cancer. (Jinghui Zhang, PhD)
Pediatric Cancer Genome Project scientists begin to uncover treasures.
Scientists working on the Pediatric Cancer Genome Project develop a powerful new tool to pinpoint the structural variations that give rise to childhood cancers.
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project scientists pioneer way to find more chromosomal aberrations in tumors; results likely to advance understanding of cancer