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    Erin Schuetz, PhD

    Erin G. Schuetz, PhD

    Member, St. Jude Faculty

    Departments

    Pharmaceutical Sciences

    Contact Information

    Erin Schuetz, PhD
    Pharmaceutical Sciences
    MS 313, Room I5303
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: erin.schuetz@stjude.org
    Phone: (901) 595-2205
    FAX: (901) 595-3125

    Education

    PhD - Medical College of Virginia/VCU, Richmond
    BS - St. Mary's College, Notre Dame, Indiana


    Research Interests

    The influence of Pqp on CYP3A regulation


    Selected Publications

    Barr J, Choughule K, Nepal S, Wong T, Chaudhry AS, Joswig-Jones CA, Zientek MA, Strom S, Schuetz EG, Thummel K, Jones JP. Why Do Most Human Liver Cytosol Preparations Lack Xanthine Oxidase Activity? Drug Metab Dispos Jan 15, 2014. [Epub ahead of print]

    Chaudhry AS, Thirumaran RK, Yasuda K, Yang X, Guengerich FP, Strom SC, Schuetz EG. Genetic variation in Aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple Cytochrome P450s. Drug Metab Dispos 41(8):1538-47, 2013. (PMCID: PMC3701191) Selected as 2013 ASPET James R. Gillette DMD Best Paper Award

    Yue-Ming Wang, Wenwei Lin, Sergio C. Chai, Jing Wu, Su Sien Ong, Schuetz EG, Taosheng Chen. Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicology and Applied Pharmacology Oct 1;272(1):96-107, 2013. (PMCID: PMC3775940)

    Yasuda K, Cline CB, Vogel P, Onciu M, Fatima S, Sorrentino BP, Thirumaran RK, Ekins S, Urade Y, Fujimori K, Schuetz EG. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood-cerebrospinal Fluid Barrier. Drug Metab Dispos Apr 41(4):923-31, 2013. (PMCID: PMC3608452)

    Ilic K, Hawke RL, Thirumaran RK, Schuetz EG, Hull JH, Kashuba AD, Stewart PW, Lindley CM, Chen ML. The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans. Drug Metab Dispos Mar 41(3):575-81, 2013. (PMC in process)

    Zimmerman EI, Roberts JL, Li L, Finkelstein D, Gibson A, Chaudhry AS, Schuetz EG, Rubnitz JE, Inaba H, Baker SD. Ontogeny and sorafenib metabolism. Clin Cancer Res Oct 15;18(20):5788-95, 2012. (PMCID:PMC3490489)

    Wang Z, Schuetz EG, Xu Y, Thummel KE Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol Sep 15, 2012. (PMCID: PMC3549031)

    Zheng XE, Wang Z, Liao MZ, Lin YS, Shuhart MC, Schuetz EG, Thummel KE. Human PXR-mediated induction of intestinal CYP3A4 attenuates 1a, 25-dihydroxyvitamin D3 function in human colon adenocarcinoma LS180 cells. Biochemical Pharmacology Aug 1;84(3):391-401, 2012. (PMCID:PMC3372629)

    Kalabus JL, Cheng Q, Jamil RG, Schuetz EG, Blanco JG. Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo [a]pyrene. Toxicology Letters Apr 15;211(3):266-273, 2012. (PMCID: PMC3359411)

    Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Qi A, Cheng C, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochem Pharmacol March 30, 2012.

    Lamba J, Hebert JM, Schuetz EG, Klein TE, Altman RB. PharmGKB summary: very important pharmacogene information for CYP3A5. Pharmacogenet Genomics March 8, 2012. (Epub ahead of print)

    Brown KC, Hosseinipour MC, Hoskins JM, Thirumaran RK, Tien HC, Weigel R, Tauzie J, Shumba I, Lamba JK, Schuetz EG, McLeod HL, Kashuba AD, Corbett AH. Exploration of Cytochrome P450 and Drug Transporter Genotypes and Correlations with Nevirapine Exposure in Malawians. Pharmacogenomics 13(1):113-21, 2012 (PMC in progress)

    Wang Y, Guan S, Acharya P, Liu Y, Thirumaran RK, Brandman R, Schuetz EG, Burlingame AL, Correia MA. Multisite phosphorylation of human liver cytochrome P450 3A4 enhances its gp78- and CHIP-mediated ubiquitination: A pivotal role of its S478 residue in the gp78-catalyzed reaction. Mol Cell Proteomics Nov 17, 2011. (PMC in progress)

    Meyer Zu Schwabedissen HE, Ware JA, Finkelstein D, Chaudhry AS, Lemay S, Leon-Ponte M, Strom SC, Zaher H, Schwarz UI, Freeman DJ, Schuetz EG, Tirona RG, Kim RB. Hepatic OATP transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis. Hepatology Aug;54(2):644-54, 2011. doi: 10.1002/hep.24391. (PMCID: PMC3164486)

    Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz EG, Nickerson DA, Thummel KE, Rieder MJ, Rettie AE, Ratain MJ, Cox NJ, Brown CD. Genetic identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLOs Genetics 7(5):e1002078, 2011. (PMCID: PMC3102751)

    Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz EG, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, Blair IA, Potter DA. CYP3A4 mediates growth of ER+ breast cancer cells, in part, by nuclear translocation of phospho-Stat3 through biosynthesis of ({+/-})-14,15-EET. J Biol Chem 286:17543-59, 2011. (PMCID: PMC3093829)

    Smith NF, Mani S, Schuetz EG, Yasuda K, Sissung TM, Bates SE, Figg WD, Sparreboom A. Induction of CYP3A4 by vinblastine: role of the nuclear receptor NR1I2. Ann Pharmacother 44:1709-17, 2010. (PMCID: PMC 3100585)

    Meyer zu Schwabedissen HE, Bottcher K, Chaudry A, Koremer HK, Schuetz EG, Kim RB. LXRα (NR1H3) and FXR (NR1HR4) are the major transcriptional regulators of OATP1B1. Hepatology 52:1797-807, 2010.

    Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich F, Strom SC, Schuetz EG, Rushmore T, Ulrich R, Slatter J, Schadt EE, Kasarskis A, Lum P. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res 20:1020-36, 2010. (PMCID: PMC2909567)

    Lamba V, Panetta JC, Strom S, Schuetz EG. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. J Pharmacol Exp Ther 332(3):1088-99, 2010. (PMCID: PMC2835441)

    Chaudhry AS, Urban TJ, Lamba JK, Birnbaum AK, Remmel RP, Strom S, You JH, Liu, D, Singh R, Kasperaviciute D, Catarino C, Radtke R, Sisodiya SM, Goldstein DB, Schuetz EG. CYP2C9*1B promoter SNPs, in LD with CYP2C19*2, affect phenytoin auto-induction of clearance and maintenance dose. J Pharmacol Exp Ther 332(2):599-611, 2010. (PMCID: PMC2812115)

    Deeken JF, Robey RW, Shukla S, Steadman K, Schuetz EG, Holbeck S, Ambudkar SV, Bates SE. Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharm 76(5):946-56, 2009. (PMCID: PMC2774997)

    Yang J, Bogni A, Schuetz EG, Ratain M, Eileen Dolan M, McLeod H, Gong L, Thorn C, Relling MV, Klein TE, Altman RB. Etoposide pathway. Pharmacogenet Genomics 19(7):552-553, 2009. (PMCID: N/A)

    Innocenti F, Kroetz DL, Schuetz EG, Dolan ME, Ramírez J, Relling M, Chen P, Das S, Rosner GL, Ratain MJ. J Clin Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. Oncol 1;27(16):2604-14, 2009. (PMCID: PMC2690389)

    Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Elkins S, Schuetz EG. The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metab Dispos Jun;37(6):1295-304, 2009. (PMCID: PMC2683691)

    Pondugula SR, Brimer-Cline C, Wu J, Schuetz EG, Tyagi RK, Chen T. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pegnane x receptor. Drug Metab Dispos 374(4):719-30, 2009. (PMCID: PMC2680541)

    Perera MA, Cox NJ, Hanauer S, Das S, Ratain M, Schuetz EG, Di Rienzo A. Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans. Pharmacogenomics J 9(1): 49-60, 2009. (PMCID: PMC2754748)

    Baker SD, Verweij J, Cusatis GA, van Schaik RH, Marsh S, Orwick SJ, Franke RM, Hu S, Schuetz EG, Lamba V, Messersmith WA, Wolff AC, Carducci MA, Sparreboom A. Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther 85(2): 155-63 2009. (PMCID: N/A)

    Last update: February 2014