Related Topics

    Chi: News Releases & Feature Stories

    Tumor suppressor protein plays key role in maintaining immune balance

    St. Jude Children’s Research Hospital scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function; discovery offers new focus for improving treatment of autoimmune diseases. (Hongbo Chi, PhD)

    Tumor suppressor protein helps immune system stay balanced

    Scientists at St. Jude have discovered that a protein widely known for preventing tumors also helps regulatory T cells do their job.

    Waking up the body’s defense system

    Blood contains a large number of T cells, which act like soldiers that defend against infections and other invaders. When T cells detect a threat, they “wake up” and start multiplying into an army to destroy it. How T cells are triggered to multiply has been largely a mystery.

    Researchers discover how a protein complex revs up T cell activation to fight infections

    St. Jude Children’s Research Hospital scientists find mechanism that launches production of the specialized T cells essential for combating infectious agents and that offers new therapeutic possibilities. (Dr. Hongbo Chi)

    Maintaining immune balance involves an unconventional mechanism of T cell regulation

    St. Jude Children’s Research Hospital study challenges prior understanding of the process regulating specialized T cells that are essential for a balanced immune system. (Dr. Hongbo Chi)

    Signaling molecule identified as essential for maintaining a balanced immune response

    St. Jude Children’s Research Hospital scientists show that the molecule serves as a bridge between the two arms of the immune system that provides a new mechanism guiding T cell differentiation

    Tumor suppressor protein is a key regulator of immune response and balance

    St. Jude Children’s Research Hospital scientists provide insight into immune system biology and identify the mechanism that keeps white blood cell activity at a minimum until the specific immune response is needed.

    New pathway regulates immune balance and offers promising drug development target

    St. Jude Children’s Research Hospital scientists uncover a novel pathway for regulating T lymphocytes that play very different roles in inflammation. The mechanism offers a promising target for new drugs against autoimmune disorders.