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Solid Tumor : melanoma
This study is for patients ages 12 to 17 years suffering from malignant melanoma and cannot be cured with surgery, or has been previously treated and is no longer responding to treatment.
RO5185426 is an investigational drug being studied by Roche. “Investigational” means that this drug has not been approved by the Food and Drug Administration for use in children with your disease at this time. RO5185426 has recently been approved for treatment of adults with malignant melanoma.
Researchers have found that a large number of melanomas, as well as other tumors, have mutations (changes) in a gene called the BRAF gene. Genes are a specific part of your DNA that contain information on hereditary characteristics such as hair color and eye color.
The BRAF gene makes a protein called BRAF, which is involved in sending signals within cells for cell growth. Certain mutations in the BRAF gene cause a change in the BRAF protein that can increase the growth and spread of cancer cells. RO5185426 works by preventing these altered BRAF proteins from working, which may result in blocking the growth and spread of the cancer cells. Only people with this mutation in the BRAF gene are eligible to take part in this study and receive this drug.
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Alberto Pappo, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.