PATIENT MEDICATION

Amikacin

 

What is amikacin?

Amikacin (also called Amikin®) is an aminoglycoside antibiotic used to treat infections. Amikacin is available as a clear liquid given by a vein (IV).

Laboratory testing for amikacin

The staff will measure the amount of amikacin in your blood shortly after you receive IV amikacin. These blood tests tell the staff whether you are receiving an effective dose of the medicine and help decrease the chance for side effects.

A few patients (about 1 in 500 patients) are at very high risk of developing hearing loss as a side effect of amikacin. A genetic test called mt-RNR1 can be done to find out if you have an increased risk of developing hearing loss from amikacin. If the test finds that you have this increased risk, your doctor may consider using another medicine to treat your infection. To learn more about mt-RNR1 and amikacin, talk with your doctor or pharmacist, and see “Do You Know… mt-RNR1 and aminoglycosides.” For more details, go to stjude.org/pg4kds.

Possible side effects of IV amikacin

  • Decreased kidney function
  • Feeling dizzy
  • Trouble standing
  • Hearing a roaring noise
  • Loss of hearing
  • Muscle twitching or feeling weak
  • Need to urinate less
  • Diarrhea
  • Nausea
  • Vomiting
  • Upset stomach
  • Allergic reaction with these symptoms: rash, hives, itching, chills, fever, short of breath, muscle aches, swelling of the face or neck, headache, tight feeling in throat, or coughing

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

In case of a severe side effect or reaction, call the doctor, nurse, or pharmacist at 901-595-3300. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833).

Special instructions for amikacin

  • If you are not urinating as often as usual (decreased kidney function), tell your doctor before you receive the IV form of amikacin.
  • Tell your doctor right away if you are not urinating as often as usual while you are receiving IV amikacin.
  • If you are an outpatient receiving IV amikacin through a portable pump (such as an Eclipse® device) follow these guidelines:
    • Finish all doses of amikacin as your doctor instructed, even if you think your condition has improved.
    • Store amikacin in the refrigerator or on ice.
    • Place one (1) dose of amikacin at room temperature about one (1) hour before the dose is given.
  • Tell your doctor right away if you have any changes in hearing while you are receiving the IV form of amikacin.
  • While you are receiving IV amikacin, it is important to stay well-hydrated. If you are not receiving IV fluids, drink plenty of fluids. Ask your doctor, nurse, or pharmacist how much fluid you should have each day.
  • Some medicines may make the side effects of IV amikacin worse. These medicines include furosemide, cyclosporine, amphotericin B or Ambisome®, tacrolimus, cephalosporin antibiotics (such as Cefepime® and Ceftazidime®), cisplatin, and carboplatin.
  • Tell your doctor if you are taking any of these medicines, or if you start taking any new medicines while you are receiving IV amikacin.

 

This document is not intended to take the place of the care and attention of your personal physician or other professional medical services. Our aim is to promote active participation in your care and treatment by providing information and education. Questions about individual health concerns or specific treatment options should be discussed with your physician.

St. Jude complies with health care-related federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.

ATTENTION: If you speak another language, assistance services, free of charge, are available to you. Call 1-866-278-5833 (TTY: 1-901-595-1040).

ATENCIÓN: si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al 1-866-278-5833 (TTY: 1-901-595-1040).

تنبيه: إذا كنت تتحدث باللغة العربية فيمكنك الاستعانة بخدمات المساعدة اللغوية المتوفرة لك مجانا. .يرجى الاتصال بالرقم. 5833-278-866-1  (الهاتف النصي: 1040-595-901-1).