Deferasirox (Exjade®)

What is deferasirox?

Deferasirox (also called Exjade®) is used to remove excess iron in the body caused by blood transfusions or the body absorbing too much iron. It works by binding to iron in the body. This excess iron is then removed through the stool. Deferasirox is available as a 125 mg, 250 mg, and 500 mg white, round tablet for making a suspension. The suspension is taken by mouth.

How to take deferasirox

• Tablets cannot be chewed or swallowed whole. The tablets must be dissolved in liquid before taking.
• Read the directions on the bottle carefully to make sure you take this medicine correctly.
• To make the suspension, drop tablets in a glass of water or fruit juice. Stir to mix evenly. Then drink all liquid. Rinse any remaining medicine in the glass with more water or juice and drink.
• Deferasirox should be taken on an empty stomach one (1) time a day, at least 30 minutes before eating. Try to take this medicine around the same time every day.
• If you have problems taking deferasirox on an empty stomach, please contact your doctor or pharmacist.

Possible side effects of deferasirox

• Nausea and vomiting
• Stomach pain
• Diarrhea
• Feeling tired
• Rash
• Trouble breathing or swallowing
• Hoarse throat
• Liver problems
• Kidney problems

These are the most common side effects, but there might be others. Please report all the side effects to the doctor or nurse.

In case of severe side effect or reaction, call the doctor, nurse, or the pharmacist at 901-595-3300. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is connected.

Special instructions for deferasirox

• It is important that you take deferasirox exactly as your doctor tells you. If you miss a dose, take the missed dose 2 hours after your last meal or 30 minutes before eating. Do not take a missed dose if it is close to the time the next dose is due.
• Do not take aluminum-containing antacids such as Maalox® at the same time as this medicine.
• Deferasirox may cause you to feel dizzy and drowsy. Do not operate heavy equipment or drive a motor vehicle until you see how this medicine will affect you.
• This medicine may cause skin rash. Contact your doctor if you develop a skin rash.
• It is important that you receive routine blood tests and MRI to see how your body is responding to deferasirox. Please attend all scheduled doctor appointments.
• It is important to let your doctor or pharmacist know of any medications that you are taking while on deferasirox. Other medications, including over-the-counter drugs, may interact with deferasirox.
• Contact your doctor if you have severe nausea, vomiting, or diarrhea. Drink plenty of fluid to keep hydrated.