Skip to main content


Efavirenz / emtricitabine / tenofovir (Atripla®)


What is Atripla®?

Atripla® is a tablet that contains 3 medicines used to treat infection caused by the human immunodeficiency virus (HIV). The 3 medications are called efavirenz (Sustiva®), emtricitabine (Emtriva®), and tenofovir (Viread®). Efavirenz belongs to a group of medicines known as nonnucleoside reverse transcriptase inhibitors (NNRTIs). Emtricitabine and tenofovir belong to a group called nucleoside reverse transcriptase inhibitors (NRTIs). Atripla® can slow down how soon you will see symptoms of HIV or slow the damage caused by HIV, but it cannot cure HIV infection. Atripla® tablets contain 600 mg of efavirenz, 200 mg emtricitabine, and 300 mg tenofovir.

How to take Atripla®

  • This tablet is usually taken one (1) time each day.
  • Atripla® should be taken with water on an empty stomach.

Possible side effects of Atripla®

  • Rash
  • Feeling more tired than usual
  • Low blood counts
  • Headache
  • Nausea
  • Vomiting
  • Unusual dreams
  • Feeling dizzy or drowsy

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

In case of severe side effect or reaction, call the doctor, nurse, or pharmacist at 901-595-3300. If you are outside the Memphis area, dial toll- free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is connected.

Special instructions for Atripla®

  • Atripla® tablets should be stored at room temperature and away from heat and moisture.
  • Administer Atripla® with water on an empty stomach due to possible effects of food with the medication.
  • Take Atripla® at bedtime to decrease adverse effects such as feeling dizzy and drowsy.
  • Some side effects, such as low blood counts, can be found with blood tests, So it is very important that you come to clinic at regularly planned times and have blood tests done.


This document is not intended to take the place of the care and attention of your personal physician or other professional medical services. Our aim is to promote active participation in your care and treatment by providing information and education. Questions about individual health concerns or specific treatment options should be discussed with your physician.

St. Jude complies with health care-related federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.

ATTENTION: If you speak another language, assistance services, free of charge, are available to you. Call 1-866-278-5833 (TTY: 1-901-595-1040).

ATENCIÓN: si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al 1-866-278-5833 (TTY: 1-901-595-1040).

تنبيه: إذا كنت تتحدث باللغة العربية فيمكنك الاستعانة بخدمات المساعدة اللغوية المتوفرة لك مجانا. .يرجى الاتصال بالرقم. 5833-278-866-1  (الهاتف النصي: 1040-595-901-1).