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Sacubitril/valsartan (Entresto®)


What is sacubitril/valsartan?

Sacubitril/valsartan (also called Entresto®) is used to treat heart failure (weak heart). It can lower the number of hospital visits and risk of death from heart failure. It is available as a 24/26mg, 49/51mg and 97/103mg tablet taken by mouth. It can be made into a liquid taken by mouth.

Possible side effects of sacubitril/valsartan

  • Cough

Call the doctor right away if you have any of the following side effects:

  • Allergic reaction: Itching or hives; swelling in your face or hands; swelling or tingling in your mouth or throat; chest tightness; trouble breathing
  • Signs of kidney problems: Unable to pass urine, change in amount of urine passed, blood in the urine, or a big weight gain
  • Signs of high potassium: Heartbeat that does not feel normal, change in thinking clearly, numbness or tingling, short of breath
  • Feeling lightheaded, feeling dizzy, fainting
  • Feeling very tired or weak

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse. In case of a severe side effect or reaction, call the doctor, nurse or pharmacist at 901-595-3300. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833).

How to take sacubitril/valsartan

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Take your medicine at the same time each day.
  • Tablet: Take the tablet with or without food.
    • Store the medicine in a closed container at room temperature, away from heat, moisture and direct light.
  • Liquid: Take the liquid with or without food. Shake the bottle well before taking a dose.
    • Store the liquid at room temperature. Do not refrigerate. Throw away after expiration date on the label.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • Missed dose: Take a dose as soon as you remember. If it is close to your next dose, do not take the missed dose. Take the next dose at your regular time. Do not take extra medicine to make up for a missed dose.

Special instructions for sacubitril/valsartan

  •  Tell your doctor about any of the following:
    • You are pregnant or breastfeeding
    • You have kidney disease
    • You have liver disease
    • You have ever had a very bad or life-threatening reaction called angioedema. Signs may include swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; or unusual hoarseness.
    • You are taking or have recently taken any of these drugs: benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril or trandolapril.
    • You are taking any of these drugs: azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan or telmisartan
    • You are taking a drug that has aliskiren in it, and you also have diabetes or kidney problems


This document is not intended to take the place of the care and attention of your personal physician or other professional medical services. Our aim is to promote active participation in your care and treatment by providing information and education. Questions about individual health concerns or specific treatment options should be discussed with your physician.

St. Jude complies with health care-related federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.

ATTENTION: If you speak another language, assistance services, free of charge, are available to you. Call 1-866-278-5833 (TTY: 1-901-595-1040).

ATENCIÓN: si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al 1-866-278-5833 (TTY: 1-901-595-1040).

تنبيه: إذا كنت تتحدث باللغة العربية فيمكنك الاستعانة بخدمات المساعدة اللغوية المتوفرة لك مجانا. .يرجى الاتصال بالرقم. 5833-278-866-1  (الهاتف النصي: 1040-595-901-1).