Trimethoprim / sulfamethoxazole

What is trimethoprim / sulfamethozazole?

Trimethoprim/sulfamethozazole is used to prevent or treat infections. It is also called SMX-TMP, Bactrim^®, or Septra^® or Sulfatrim^® SMX-TMP is available as a green or white tablet and as a pink or white liquid. All are taken by mouth. SMX-TMP is also available as a clear liquid given by vein (IV).

Possible side effects of trimethoprim / sulfamethozazole

Early

• Nausea, vomiting
• Diarrhea
• Rash
• Pain in abdomen

Later (usually more than a day after treatment starts)

• Pain in abdomen
• Low blood counts

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

In case of a severe side effect or reaction, call the doctor, nurse, or pharmacist at 595-3300. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is connected.

Special instructions for trimethoprim / sulfamethozazole

• SMX-TMP can prevent a fatal pneumonia (Pneumocystis carinii) that can occur during chemotherapy. For the medicine to work well, you must take it exactly as instructed, every Monday, Tuesday, and Wednesday. Taking a smaller amount or missing a dose decreases protection. Giving more medicine does not increase protection.
• Some patients may take SMX-TMP every day to treat certain infections.
• Store this medicine at room temperature.
• Take SMX-TMP with meals or on an empty stomach.
• Shake SMX-TMP liquid well before taking each dose. Use an oral syringe or medicine cup to make sure you take the correct amount.
• Be sure you drink plenty of fluids while you are taking SMX-TMP. Your doctor or nurse will tell you how much liquid you need to drink each day.