Bone Marrow (Stem Cell) Transplant "Do you know ..." is an educational series for patients and their families. Harvesting bone marrow stem cells - Do You Know Educational Series The harvest of bone marrow stem cells is very similar to a bone marrow aspiration. The donor will receive anesthesia so no pain will be felt, and the donor will have no memory of the procedure. Peripheral blood stem cell donation - Do You Know Educational Series Stem cell donors are sometimes needed for patients who require a stem cell transplant. The donated stem cells can come from the bone marrow or from the peripheral blood. Peripheral blood is blood in the veins.