Hui Zhang, PhD
Hui Zhang, PhD

Hui Zhang, PhD

Associate Member, St. Jude Faculty



BS – Nankai University (1998)
MS – Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (2001)
MS – University of Rochester (2005)
PhD – University of Rochester (2010)

Research Interests

  • Missing data
  • Longitudinal discrete data analysis
  • U-statistics
  • Survival analysis
  • Computational neuroscience
  • Count data in next generation sequencing 

Selected Publications

Chen T, Wu P, Tang W, Zhang H, Feng C, Kowalski J, Tu X. Variable Selection for Distribution-free Models for Longitudinal Zero-inflated Count Responses. Statistics in Medicine 35(16):2770-2785, 2016. DOI: 10.1002/sim.6892

Chen T, Lu N, Arora J, Katz I, Bossarte R, He H, Xia Y, Zhang H, Tu XM. Power Analysis for Cluster Randomized Trials with Binary Outcomes Modeled by Generalized Linear Mixed-effects Models. Journal of Applied Statistics 43(6):1104-1118, 2016.

Chen T, Kowalski J, Chen R, Wu P, Zhang H, Feng C, Tu XM. Rank-preserving regression for longitudinal data with missing responses. Statistics in Medicine 35:3333-3346, 2016. DOI: 10.1002/sim.6930

Zhang B, Liu W, Zhang H, Chen Q, Zhang Z. A Note on Misspecification in Joint Modeling of Correlated Data with Informative Cluster Sizes. Journal of Statistical Planning and Inference 170:46-63, 2016. doi:10.1016/j.jspi.2015.09.005

Conklin HM, Ogg RJ, Ashford JM, Scoggins MA, Zou P, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Jeha S, Huang L, Zhang H. Computerized Cognitive Training for Amelioration of Cognitive Late Effects among Childhood Cancer Survivors: A Randomized Controlled Trial. Journal of Clinical Oncology 33(33): 3894-3902, 2015. doi: 10.1200/JCO.2015.61.6672

Peck KR, Tyc VL, Huang Q, Zhang H. Reduction of Secondhand Smoke Exposure in the Cars of Children with Cancer. Journal of Pediatric Oncology Nursing 32(6):401-409, 2015. doi: 10.1177/1043454214563755

Phipps S, Long A, Willard V, Okado Y, Hudson M, Huang Q, Zhang H, Noll R. Parents of Children with Cancer: At-Risk or Resilient? Journal of Pediatric Psychology 40(9):914-925, 2015. doi: 10.1093/jpepsy/jsv047

Cox LE, Ashford JM, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Ogg RJ, Jeha S, Willard VW, Huang L, Zhang H, Conklin HM. Feasibility and Acceptability of a Remotely-Administered Computerized Intervention to Address Cognitive Late Effects among Childhood Cancer Survivors. Neuro-Oncology Practice 2(2):78-87, 2015. doi: 10.1093/nop/npu036

Willard VW, Conklin HM, Huang L, Zhang H, Kahalley LS. Concordance of Parent-, Teacher- and Self-Report Ratings on the Conners 3 in Adolescent Survivors of Cancer. Psychological Assessment 28(9):1110-1118, 2016. doi: 10.1037/pas0000265. PubMed PMID: 27537005; PubMed Central PMCID: PMC4991558

Qin L, Ma S, Huang YT, Zhang H, Cao H. Array Platform Modeling and Analysis (A). Cancer Informatics 13(S4):91–93, 2014 doi: 10.4137/CIN.S22973

Lu N, Chen T, Wu P, Gunzler D, Zhang H, He H, Tu XM, Kowalski J. Functional Response Models for Intra-class Correlation Coefficients. Journal of Applied Statistics 41(11):2539-2556, 2014. DOI: 10.1080/02664763.2014.920780

Nicholson JS, McDermott MJ, Huang Q, Zhang H, Tyc VL. Full and home smoking ban adoption after a randomized controlled trial targeting second-hand smoke exposure reduction. Nicotine & Tobacco Research 17(5):612-616, 2015. doi: 10.1093/ntr/ntu201.

Pu J, Wang S, Yin Y, Zhang G, Carter RA, Wang J, Xu G, Sun H, Wang M, Wen C, Wei Y, Wang D, Zhu B, Lemmon G, Jiao Y, Duan S, Wang Q, Du Q, Sun M, Bao J, Sun Y, Zhao J, Zhang H, Wu G, Liu J, Webster RG. Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus. PNAS, Proceedings of the National Academy of Sciences 112:548-553, 2015. doi: 10.1073/pnas.1422456112.

Willard VW, Qaddoumi I, Chen S, Zhang H, Brennan R, Rodriguez-Galindo C, Wilson MW, Phipps S. Developmental and Adaptive Functioning in Children with Retinoblastoma: A Longitudinal Investigation.Journal of Clinical Oncology 32:2788-2793, 2014. doi: 10.1200/JCO.2013.53.1996.

Willard VW, Leung W, Huang Q, Zhang H, Phipps S. Cognitive Outcome After Pediatric Stem-Cell Transplantation: Impact of Age and Total-Body Irradiation. Journal of Clinical Oncology 32:3982-3988, 2014. doi: 10.1200/JCO.2014.56.2223.

Chen R, Chen T, Lu N, Zhang H, Wu P, Feng C and Tu XM. Extending the Mann-Whitney-Wilcoxon Rank Sum Test to longitudinal data analysis with covariates. Journal of Applied Statistics 41(12):2658-2675, 2014. doi: 10.1080/02664763.2014.925101.

Khatoon Z, Figler B, Zhang H, Cheng F. Introduction to RNA-Seq and Its Application to Drug Discovery and Development. Drug Development Research 75:324-330, 2014.

Lu N, Chen T, Wu P, Gunzler D, Zhang H, He H, Tu XM, and Kowalski J. Functional Response Models for Intra-class Correlation Coefficients. Journal of Applied Statistics 41(11):2539-2556, 2014. doi: 10.1080/02664763.2014.920780.

Knight SJ, Conklin HM, Schreiber J, Palmer S, Armstrong CL, Wallace D, Bonner M, Swain MA, Chapieski L, Mabbott D, Boyle R, Huang Q, Zhang H, Anderson V, Gajjar A. Working memory abilities among children treated for medulloblastoma: Parent report and child performance. Journal of Pediatric Psychology 39:501-511, 2014. doi: 10.1093/jpepsy/jsu009.

Schreiber JE, Gurney JG, Palmer SL, Bass JK, Wang M, Chen S, Zhang H, Swain M, Chapieski ML, Bonner MJ, Mabbott DJ, Knight SJ, Armstrong CL, Boyle R, Gajjar A. Examination of Risk Factors for Intellectual and Academic Outcomes following Treatment for Pediatric Medulloblastoma. Neuro-Oncology 16:1129-1136, 2014. doi: 10.1093/neuonc/nou006.

Bettini M, Blanchfield JL, Castellaw A, Zhang Q, Nakayama M, Smeltzer MP, Zhang H, Hogquist KA, Evavold BD, Vignali DA. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. Journal of Immunology 193:571-579, 2014. doi: 10.4049/jimmunol.

Phipps S, Klosky J, Long A, Hudson M., Huang Q, Zhang H, Noll RB. Perception of Cancer as Traumatic Event, Posttraumatic Stress, and Psychological Growth in Children with Cancer. Journal of Clinical Oncology 32(7):641-646, 2014. doi: 10.1200/JCO.2013.49.8212.

Lindwall JJ, Russell K, Huang Q, Zhang H, Vannatta K, Barrera M, Alderfer M, Phipps S. Adjustment in Parents of Children Undergoing Stem Cell Transplantation. Biology of Blood and Marrow Transplant 20:543-548, 2014. doi: 10.1016/j.bbmt.2014.01.007

Gunzler D, Chen T, Wu P, Zhang H. Introduction to Mediation Analysis with Structural Equation Modeling. Shanghai Archives of Psychiatry 25(6):390-394, 2013. doi: 10.3969/j.issn.1002-0829.2013.06.009.

Zhang H, Holden-Wiltse J, Wang J, Liang H. A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC50. Plos One 8(8):e69301, 2013. doi:10.1371/journal.pone.0069301.

Tyc VL, Huang Q, Nicholson J, Schultz B, Hovell MF, Lensing S, Vukadinovich C, Hudson MM, Zhang H. Intervention to Reduce Secondhand Smoke Exposure Among Children with Cancer: A Controlled Trial. Psycho-Oncology 22:1104-1111, 2013. doi:0.1002/pon.3117.

Guy CS, Vignali KM, Temirov J, Bettini M, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Aifantis I, Davis MM, Vignali DA. Distinct T cell receptor signaling pathways drive proliferation and cytokine production in T cells. Nature Immunology 14:262-270, 2013.

Zhu L, Zhao H, Sun J, Pounds S, Zhang H. Joint Analysis of Longitudinal Data and Recurrent Episodes Data with Application to Medical Cost Analysis. Biometrical Journal 55:5-16, 2013.

Show More

Zhang H, Yu Q, Feng C, Gunzler D, Wu P, Tu XM. A new look at the difference between the GEE and the GLMM when modeling longitudinal count responses. Journal of Applied Statistics 39:2067-2079, 2012.

Pounds SB, Gao CL, Zhang H. Empirical Bayesian Selection of Hypothesis Testing Procedures for Analysis of Sequence Count Expression Data. Statistical Applications in Genetics and Molecular Biology 11(5), 2012. doi: 10.1515/1544-6115.1773.

Brinkman T, Palmer SL, Chen S, Zhang H, Chapieski L, Swain M, Bonner MJ, Janzen L, Knight S, Armstrong CL, Boyle R, Gajjar A. Parent-Reported Social Outcomes After Treatment for Pediatric Embryonal Tumors: A Prospective Longitudinal Study. Journal of Clinical Oncology 30:4134-4140, 2012.

Zhang H, Lu N, Feng C, Thurston SW, Xia Y, Tu XM. On Fitting Generalized Linear Mixed-effects Models for Binary Responses using Different Statistical Packages. Statistics in Medicine 30:2562-2572, 2011.

Zhang H, Xia Y, Chen R, Lu N, Tang W, Tu XM. On Modeling Longitudinal Binomial Responses: Implications from Two Dueling Paradigms. Journal of Applied Statistics38:2373-2390, 2011.

Liang Z, Sun J, Srivastava DK, Tong X, Leisenring W, Zhang H, Robison LL. Semiparametric Transformation Models for Joint Analysis of Multivariate Recurrent and Terminal Events. Statistics in Medicine 30:3010-3023, 2011.

Yu Q, Tang W, Marcus S, Ma Y, Zhang H, Tu XM. Modeling Sensitivity and Specificity with a Time-varying Reference Standard within a Longitudinal Setting. Journal of Applied Statistics 37:1213-1230, 2010.

Ma Y, Gonzalez Della Valle A, Zhang H, Tu XM. A U-statistics based Approach for Modeling Cronbach Coefficient Alpha within a Longitudinal Data Setting. Statistics in Medicine 29:659-670, 2010.

Feng C, Zhang H, Tu XM. A Duality of Sample Size Calculation Based on Odds Ratio and on Risk Difference. JP Journal of Biostatistics 4:203-212, 2010.

Lu N, Tang W, He H, Yu Q, Crits-Christoph P, Zhang H, Tu XM. On the Impact of Parametric Assumptions and Robust Alternatives for Longitudinal Data Analysis.Biometrical Journal 51:627-643, 2009.

Moss AJ, Hall WJ, et al. (Zhang H  was listed as a biostatistician for MADIT-CRT Trial.) Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events. New England Journal of Medicine 361:1329-1338, 2009.

Ji XH, Ji JZ, Zhang H, Li BM. Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology33:2263-2271, 2008.

Zhang H, Ameen N, Melvin JE, Vidyasagar S. Acute Inflammation Alters Bicarbonate Transport in Mouse Ileum. Journal of Physiology 581:1221-33, 2007.

Basavappa S, Vulapalli SR, Zhang H, Yule D, Coon S, Sundaram U. Chloride channels in the small intestinal cell line IEC-18. Journal of Cellular Physiology 202:21-31, 2005.

Zhang XH*, Zhang H*, Tu Y*, Gao X, Zhou C, Jin M, Zhao G, Jing N, Li BM, Yu L. Identification of a novel protein for memory regulation in the hippocampus.Biochemistry and Biophysics Research Communication 334:418-424, 2005. *Co-first authors.

Zhang H, Mitchell DR. Cpc1, a Chlamydomonas central pair protein with an adenylate kinase domain. Journal of Cell Science 117:4179-4188, 2004. *Comments in Journal of Cell Science. 117:1802.

Wang M, Zhang H, Li BM. Deficit in conditional visuomotor learning by local infusion of bicuculline into the ventral prefrontal cortex in monkeys. European Journal of Neuroscience 12:3787-96, 2000.

Last update: September 2016