Inside

Finding the Cures

Dario A. A. Vignali, PhD
St. Jude study shows how T cell’s machinery dials down autoimmunity
A St. Jude study shows that T cells, the body’s master immune regulators, do not use simple on/off switches to govern the cellular machinery that regulates their development and function.
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Basic Science

The diverse research at St. Jude ranges from discovery-focused and hypothesis-testing laboratory studies to clinical trials of specific agents, regimens, or therapeutic interventions. We continually seek to translate knowledge acquired through basic research into novel approaches for clinical diagnosis and treatment. At the same time, our clinical and laboratory-based investigators use the challenges encountered in the clinic to focus the efforts of our research.

The Research Behind the Cures

New function for old enzyme in fatal disease

New function for old enzyme in fatal disease

The lack of a single protein usually thought of as a run-of-the-mill enzyme that helps to recycle molecules in cells causes an incurable and often fatal disease of children. Children with this disease, called sialidosis, suffer from enlarged spleens and often develop vision problems, loss of coordination and seizures, among other symptoms. The patients generally die within the first few years of life.

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Scientific Report 2007

Scientific Report

The Scientific Report 2007 summarizes key research recently performed by investigators at St. Jude and includes a list of their peer-reviewed publications for the year 2006.