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Clinical trial data reveals what controls the staying power of T cells, affecting immunotherapy responses.
St. Jude scientists' findings were published in Cell Reports.
St. Jude Children’s Research Hospital scientists have shed light on the way ligands bind to and activate ALK, an important target for cancer drug development.
St. Jude scientists map nutrient-dependent signaling in T cells, offering possible new drug targets for treating infectious diseases, cancer and immune-mediated disorders.
St. Jude Children’s Research Hospital show how epigenetic regulation by the enzyme DNMT3A controls T-cell exhaustion providing a target for improving CAR T–cell immunotherapy.
The fourteen scientists are among the most highly cited investigators in the world during the past decade, reflecting the international reach of
St. Jude research.
St. Jude Children’s Research Hospital scientists have identified the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.
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