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Science & medicine news
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Rare inherited enzyme disorder yields insight into fibrosis
St. Jude Children’s Research Hospital scientists discovered an association between a mutation that causes a lysosomal storage disorder and fibrotic conditions, including idiopathic pulmonary fibrosis
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DNA replication machinery captured at atom-level detail
St. Jude Children’s Research Hospital scientists reveal a crystal structure that illustrates a mechanism that powers and possibly starts DNA replication.
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Too little or too much DUX4 is just right
St. Jude researchers discover protein that may improve treatment for B-ALL in some patients. Learn more about how this gene’s expression impacts development.
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Pathway discovered that prevents buildup of Alzheimer’s protein
A new pathway called LANDO may protect against neurodegeneration in Alzheimer's disease. Learn about how inhibiting this pathway may positively affect treatment.
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Childhood leukemia cannot hide from the immune system
St. Jude scientists found that despite having few mutations, pediatric acute lymphoblastic leukemia does not escape immune detection.
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Goldilocks principle helps explain the origins of the most common children’s cancer
This study provided the first detailed genomic and epigenomic map of the IGH-DUX4 rearrangement and suggested the principle a model for the IGH-DUX4 contribution to B-ALL.
