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Science & medicine news
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Exhaustion affects CAR T–cell clinical response
Clinical trial data reveals what controls the staying power of T cells, affecting immunotherapy responses. St. Jude scientists' findings were published in Cell Reports.
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Findings reveal new mechanism of activation for ALK
St. Jude Children’s Research Hospital scientists have shed light on the way ligands bind to and activate ALK, an important target for cancer drug development.
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Discovery of how immune cells sense nutrients offers new therapeutic insight
St. Jude scientists map nutrient-dependent signaling in T cells, offering possible new drug targets for treating infectious diseases, cancer and immune-mediated disorders.
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Target prevents T-cell exhaustion, boosts CAR T–cell responses
Findings from St. Jude Children’s Research Hospital show how epigenetic regulation by the enzyme DNMT3A controls T-cell exhaustion providing a target for improving CAR T–cell immunotherapy.
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St. Jude researchers are again among the world’s most highly cited scientists
The fourteen scientists are among the most highly cited investigators in the world during the past decade, reflecting the international reach of St. Jude research.
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Safety concerns raised for neuroblastoma candidate drug
St. Jude Children’s Research Hospital scientists have identified the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.