Robert Webster, PhD

Robert G. Webster, PhD

Member, St. Jude Faculty
Rose Marie Thomas Chair

Departments

Infectious Diseases


Education

PhD - Australian National University, Canberra
DSc - Otago University, New Zealand

Honors


Research Interests


Dr. Webster’s interests include the structure and function of influenza virus proteins and the development of new vaccines and antivirals; the importance of influenza viruses in wild birds as a major reservoir of influenza viruses and their role in the evolution of new pandemic strains for humans and lower animals. His curriculum vitae contains over 600 original articles and reviews on influenza viruses. He has mentored many individuals who have been successful in contributing to our knowledge of influenza as an emerging pathogen.


Selected Publications

Recent citations from more than 600 publications:

Krauss S, Stallknecht DE, Negovetich NJ, Niles LJ, Webby RJ, Webster RG. Coincident ruddy turnstone migration and horseshoe crab spawning creates an ecological 'hot spot' for influenza viruses. Proc of the Royal Society Biol Sci Nov 22;277(1699):3373-9, 2010.

Barber MR, Aldridge JR Jr, Webster RG, Magor KE. Association of RIG-I with innate immunity of ducks to influenza. Proc Natl Acad Sci U S A Mar 30;107(13):5913-8, 2010.

Salomon R, Webster RG. The influenza virus enigma. Cell. Feb 6;136(3):402-10, 2009.

Aldridge JR Jr, Moseley CE, Boltz DA, Negovetich NJ, Reynolds C, Franks J, Brown SA, Doherty PC, Webster RG, Thomas PG. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A Mar 31;106(13):5306-11, 2009.

Yen HL, Guan Y, Peiris M, Webster RG. H5N1 in Asia, in “Monographs in Virology Volume 27-Avian Influenza”, edited by Klenk HD, Matrosovich MN, Stech J, Karger, 2008.

Govorkova EA, Ilyushina NA, Boltz D, Douglas A, Yilmaz N, Webster RG. Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. Antimicrob Agents Chemother 51:1414-1424, 2007.

Boltz DA, Bouangngeun B, Sinthasak S, Phommachanh P, Rolston S, Chen HK, Guan Y, Peiris JSM, Smith GJD, Webster RG. H5N1 influenza viruses in Lao People’s Democratic Republic. Emerg Infect Dis 12:1593-1595, 2006.

Webster RG, Govorkova EA. H5N1 influenza-continuing evolution and spread. N Engl J Med 355:2174-2177, 2006.

Lipatov AS, Hoffmann E, Salomon R, Yen HL, Webster RG. Cross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/97 (H5) vaccines against infection with A/Vietnam/1203/04 (H5N1) virus in ferrets. J Infect Dis 194:1040-1043, 2006.

Govorkova EA, Webby RJ, Humberd J, Seiler JP, Webster RG. Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge. J Infect Dis 194:159-167, 2006.

Obenauer JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM,  Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW. Large-scale sequence analysis of avian influenza isolates. Science 17:1576-1580, 2006.

Webster RG, Peiris M, Chen H, Guan Y. H5N1 outbreaks and enzootic influenza. Emerg Infect Dis 12:3-8, 2006.

Salomon R, Franks J, Govorkova EA, Ilyushina NA, Yen HL, Hulse-Post DJ, Humberd J, Trichet M, Rehg JE, Webby RJ, Webster RG, Hoffmann E. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med 20:689-697, 2006.

Russel CJ, Webster RG. The genesis of a pandemic influenza virus. Cell 122:368-371, 2005.

Last update: September 2011