Raja B. Khan, MD
Raja B. Khan, MD

Raja B. Khan, MD

Associate Member, St. Jude Faculty

  • Chief, Neurology Division

Departments

Divisions

Education

Fellowship – Memorial Sloan-Kettering Cancer Center, New York, New York (1999-2001)
Residency – University of Tennessee, Memphis, Tennessee (1996-1999)
Medical School – King Edward Medical College, Lahore, Pakistan (1985)

Clinical Interests

  • Effect of cancer and its treatment on central and peripheral nervous systems

Selected Publications

Helton K, Patterson AL, Khan RB, Sadighi Z.The Complex Diagnostic Challenge in Children with Non–Central Nervous System Cancer and Cerebellar Mutism. J Child Neurol 2017 (in press).

Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Eissa H, Chemaitilly W, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky JL, Krull KR, Sabin ND, Wilson CL, Huang I-C, Bass JK, Hale K, Kaste SC, Khan RB, Srivastava DK, Yasui Y, Joshi VM, Srinivasan S, Stokes DC, Hoehn ME, Wilson MW, Ness KK, Robison LL. Approach for Classification and Severity-grading of Long-term and Late-onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort. Cancer Epidemiology. Biomarkers & Prevention 2017 (in press).

Sadighi Z, Zabrowski J, Boop F, Broniscer A, Gajjar A, Khan R. Clinical Characteristics and Long-term Outcome in Movement Disorder in Childhood Thalamic Tumors. Pediatric Neurology 2017 (in press).

Khan RB, Sadighi ZS, Zabrowski J, Gajjar A, Jeha S. Imaging Patterns and Outcome of Posterior Reversible Encephalopathy Syndrome During Childhood Cancer Treatment. Pediatr Blood Cancer 63(3):523-6, 2016.

Khan RB, Hudson MM, Ness KK, Liang Z, Srivastava D, Krull KR. Association of attention deficit disorder with bedside anti-saccades in survivors of childhood leukemia. J Child Neurol 31(2):131-133, 2016.

Khan RB, Hudson MM, Ledet DS, Morris EB, Pui CH, Howard SC, Krull KR, Hinds PS, Crom D, Browne E, Zhu L, Rai S, Srivastava D, Ness KK. Neurologic morbidity and quality of life in survivors of childhood acute lymphoblastic leukemia: a prospective cross-sectional study. J Cancer Surviv 8(4):688-696, 2014.

Sadighi ZS, Ness KK, Hudson MM, Morris EB, Ledet DS, Pui CH, Howard SC, Krull KR, Browne E, Crom D, Hinds PS, Zhu L, Srivastava D, Khan RB. Headache types, related morbidity, and quality of life in survivors of childhood acute lymphoblastic leukemia: A prospective cross sectional study. Eur J Paediatr Neurol 18(6):722-729, 2014.

Conklin HM, Reddick WE, Khan RB. Comment on Smithson et al.'s review of stimulant medication usage to improve neurocognitive and learning outcomes in childhood brain tumour survivors. Eur J Cancer 50(8):1566-1558, 2014.

Patay Z, Enterkin J, Harreld JH, Yuan Y, Lödobel U, Rumboldt Z, Khan R, Boop F. MR Imaging Evaluation of Inferior Olivary Nuclei: Comparison of Postoperative Subjects with and without Posterior Fossa Syndrome. AJNR Am J Neuroradiol 35(4):797-802, 2014.

Ledet D, Delos Santos NM, Khan R, Gajjar A, Broniscer A. Central neurogenic hyperventilation and renal tubular acidosis in children with pontine gliomas. Neurology 82(12):1099-1200, 2014.

Bhojwani D, Sabin ND, Pei D, Yang JJ, Khan RB, Panetta JC, Krull KR, Inaba H, Rubnitz JE, Metzger ML, Howard SC, Ribeiro RC, Cheng C, Reddick WE, Jeha S, Sandlund JT, Evans WE, Pui CH, Relling MV. Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. J Clin Oncol 32(9):949-959, 2014.

Reddick WE, Taghipour DJ, Glass JO, Ashford J, Xiong X, Wu S, Bonner M, Khan RB, Conklin HM. Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Pediatr Blood Cancer 61(6):1074-1079, 2014.

Khan RB, Morris EB, Pui CH, Hudson MM, Zhou Y, Cheng C, Ledet DS, Howard SC. Long-Term Outcome and Risk Factors for Uncontrolled Seizures After a First Seizure in Children With Hematological Malignancies. J Child Neurol 29(6):774-781, 2013.

Khan RB, Merchant TE, Boop FA, Sanford RA, Ledet D, Onar-Thomas A, Kun LE. Headaches in children with craniopharyngioma. J Child Neurol 28:1622-1625, 2013.

McCarville MB, Kaste SC, Hoffer FA, Khan RB, Walton RC, Alpert BS, Furman WL, Li C, Xiong X.  Contrast-enhanced sonography of malignant pediatric abdominal and pelvic solid tumors:  preliminary safety and feasibility data. Pediatr Radiol 42:824-833, 2012.

Chai Y, Bertorini TE, Khan RB, Randall M. Dermatomyositis presenting with focal scleroderma like skin changes. J Clin Neuromuscul Dis 13(4):191-5, 2012. PMID: 21482469.

Krull KR, Khan RB, Ness KK, Ledet D, Zhu L, Pui CH, Howard SC, Srivastava DK, Sabin NO, Hudson MM, Morris EB. Symptoms of attention-deficitlhyperactivity disorder in long-term survivors of childhood leukemia. Pediatr Blood Cancer 57(7):1191-1196, 2011. PMC3140624.

Conklin HM, Reddick WE, Ashford J, Ogg S, Howard SC, Morris EB, Brown R, Bonner M. Christensen R, Wu S, Xiong X, Khan RB. Long-term efficacy of methylphenidate in enhancing attention regulation, social skills, and academic abilities of childhood cancer survivors. J Clin Oncol 28:4465-4472, 2010. PMC2988638.

Conklin HM, Lawford J, Jasper BW, Morris EB, HoWard SC, Ogg SW, Wu S, Xiong X, Khan RB. Side effects of methylphenidate in childhood cancer survivors: a randomized placebo-controlled trial. Pediatrics 124:226-233, 2009. PMC2705008.

Conklin HM, Helton S, Ashford J, Mulhern RK, Reddick WE, Brown R, Bonner M, Jasper BW, Wu S, Xiong X, Khan RB. Predicting Methylphenidate Response in Long-Term Survivors of Childhood Cancer: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. J Pediatr Psychol 35:144-155, 2010. PMC2902831.

Merchant TE, Chitti RM, Li C, Xiong X, Sanford RA, Khan RB. Factors associated with neurological recovery ofbrainstem fwlction following postoperative conformal radiation therapy for infratentorial ependymoma. Int J Radiat Oncol BioI Phys 76:496-503, 2010. PMID19464817.

Morris BE, Li C, Khan RB, Sanford RA, Boop F, Pinlac R, Xiong X, Merchant TE. Evolution of neurological impairment in pediatric infratentorial ependymoma patients. J Neurooncol 94:391-398, 2009. PMC2731005.

Jasper BW, Conklin HM, Lawford J, Morris EB, Howard SC, Wu S, Xiong X, Shelso J, Khan RB. Growth effects of methylphenidate among childhood cancer survivors: a 12-month case-matched open-label study. Pediatr Blood Cancer 52:39-43, 2009. PMC2585147.

Ledet DS, Handgretinger R, Bertorini TE, Hale GA, Ribeiro RC, Khan RB. Leucooencephalopathy, transverse myelopathy and peripheral neuropathy in association with glutamic acid decarboxylase-65 (GAD) antibodies in children with cancer. J Child Neurol 23:1357-1362, 2008. PMID18474930

Helton KJ, Weeks JK, Phillips NS, Zou P, Kun LE, Khan RB, Gaijar A, Fouladi M, Broniscer A, Boop F, Li CS, Ogg RJ. Diffusion tensor imaging of brainstem tumors: Axonal degeneration of motor and sensory tracts. J Neurosurg Pediatr 1:270-276, 2008. PMID18377301.

Anghelescu DL, Burgoyne LL, Khan RB. Multiple mechanisms of perioperative brachial plexus injury. Anaesth Intensive Care 36:276-278, 2008. PMID18361025

Inaba H, Khan RB, Laningham FH, Crews KR, Pui CH, Daw NC. Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer. Ann Oncol 19:178-184, 2008. PMID17947226.

Conklin HM, Khan RB, Reddick WE, Helton S, Brown R, Howard SC, Bonner M, Christensen R, Wu S, Xiong X, Mulhern RK. Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial. J Pediatr Psychol 32:1127-1139, 2007.

Spunt SL, Freeman BB III, Billups CA, McPherson V, Khan RB, Pratt CB, Stewart CF. A Phase I clinical trial of oxaliplatin in children and adolescents with refractory solid tumors. J Clin Oncol 25:2274-2280, 2007.

Morris EB, Laningham FH, Sandlund JT, Khan RB. Posterior reversible encephalopathy syndrome in children with cancer. Pediatr Blood Cancer 48:152-159, 2007.

Show More

Khan RB, Gutin PH, Krol G, DeAngelis LM. Use of diffusion weighted magnetic resonance imaging in predicting early postoperative outcome of new neurologic deficits after brain tumor resection. Neurosurgery 59:60-66, 2006.

Khan RB, Kun LE. Stroke as a late treatment effect of Hodgkin's Disease. Nat Clin Pract Oncol (Commentary). 3:132-133, 2006.

Khan RB, Boop FA, Sanford RA. Seizures in children with low grade tumors: outcome after tumor resection and risk factors for uncontrolled seizures. J Neurosurg104:377-382, 2006.

Helton KJ, Phillips NS, Khan RB, Boop FA, Sanford RA, Zou P, Li C-S, Langston JW, Ogg RJ. Diffusion tensor imaging of tract involvement in children with pontine tumors. Am J Neuroradiol 27:786-793, 2006.

Reddick WE, Shan ZY, Glass JO, Helton S, Xiong X, Wu S, Bonner MJ, Howard SC, Christensen R, Khan RB, Pui C-H, Mulhern RK. Smaller white matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Cancer 106:941-949, 2006.

Khan RB, Onar A. Seizure recurrence and risk factors after anti-epilepsy drug withdrawal in brain tumor patients. Epilepsia 47:375-379, 2006.

Weeks J, Helton K, Conley ME, Khan RB. Diffuse CNS vasculopathy with chronic EBV infection in X-linked lymphoproliferative disease. Am J Neuro Radiol 27:884-886, 2006.

Fouladi M, Gilger E, Kocak M, Wallace D, Buchanan G, Reeves C, Robbins N, Merchant T, Kun LE, Khan R, Gajjar A, Mulhern R. Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies. J Clin Oncol 23:7152-7160, 2005.

Khan RB, Schmidt J, Tamburro R. A reversible generalized movement disorder in critically ill children with cancer. Neurocrit Care 3:146-149, 2005.

Woodard P, Helton KJ, Khan RB, Hale GA, Phipps S, Wang W, Handgretinger R, Cunningham JM. Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease. British J Haematol 129:550-552, 2005.

Khan RB, Hunt DL, Boop FA, Sanford RA, Merchant TE, Gajjar A, Kun LE. Seizures in children with primary brain tumors: incidence and long-term outcome. Epilepsy Res64:85-91, 2005.

Lowe EJ, Pui C-H, Hancock ML, Geiger TL, Khan RB, Sandlund JT. Early complications in children with acute lymphoblastic leukemia presenting with hyperleukocytosis. Pediatr Blood Cancer 44:1-6, 2005.

Krynetskiy, EE, Boop FA, Sanford RA, Kun LE, Khan RB. Types, causes and outcone of intracranial hemorrhage in children with cancer. J Neurosurg (Pediatrics) 102:31-35, 2005.

Merchant TE, Mulhern RK, Krasin MJ, Kun LE, Williams T, Xiong X, Khan RB, Lustig RH, Boop FA, Sanford RA. Preliminary results from a Phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol 22:3156-3162, 2004.

Mulhern RK, Khan RB, Kaplan S, Helton S, Christensen R, Bonner M, Brown R, Xiong X, Wu S, Gururangan S, Reddick WE. Short-term efficacy of methylphenidate: A randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. J Clin Oncol22:4795-4803, 2004.

Last update: June 2017