Seth Karol, MD
Seth Karol, MD

Seth Karol, MD

Research Associate, St. Jude Faculty

Departments

Education

MD – The Ohio State University, Columbus, Ohio
BS – Duke University, Durham, North Carolina

Research Interests

  • Utilizing genomic findings to prevent osteonecrosis in children with acute lymphoblastic leukemia
  • Optimizing therapy intensity for patients with acute leukemia

Selected Publications

Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RR, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV. A Genome-wide Approach Validates that Thiopurine Methyltransferase Activity is a Monogenic Pharmacogenomic Trait. Clin Pharm & Therapeutics Epub 2016. PMID: 27564568.

Yang W, Wu G, Broeckel U, Smith C, Turner V, Haidar C, Wang S, Carter R, Karol SE, Neale G, Crews K, Yang J, Mullighan C, Downing J, Evans W, Relling RV. Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes. Clin Pharm & Therapeutics Epub, 2016. PMID: 27311679.

Karol SE, Mattano LA, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV. Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood Feb 4;127(5):558-564, 2016. PMID: 26590194.

Karol SE*, Yang W*, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JC, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, Fernandez CA, Liu C, Smith C, Loh ML, Raetz EA, Hunger SP, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Mattano LA Jr, Relling MV. Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia. Blood Oct 8;126(15):1770-6, 2015. PMID: 26265699.

Ramsey LB, Janke LJ, Payton MA, Cai X, Paugh SW, Karol SE, Kamdem LK, Cheng C, Williams RT, Jeha S, Pui CH, Evans WE, Relling MV. Antileukemic efficacy of continuous vs discontinuous dexamethasone in murine models of acute lymphoblastic leukemia. PLoS One Aug 7;10(8):e0135134, 2015. PMID: 26252865.

Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood Jul 2;126(1):69-75, 2015. PMID: 25987655.

Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet Jun;47(6):607-14, 2015. PMID: 25938942.

Fernandez CA, Smith C, Karol SE, Ramsey LB, Liu C, Pui CH, Jeha S, Evans WE, Finkelman FD, Relling MV. Effect of premedications in a murine model of asparaginase hypersensitivity. J Pharmacol Exp Ther Mar;352(3):541-51, 2015. PMID: 25573198.

Karol SE, Coustan-Smith E, Cao X, Shurtleff S, Raimondi S, Choi J, Ribeiro R, Dahl G, Bowman P, Taub J, Degar B, Leung W, Downing J, Pui C, Rubnitz J, Campana D, Inaba H. Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol Jan;168(1):94-101, 2015. PMID: 25164427.

Kirkpatrick J, Rabbani Z, Bentley R, Hardee M, Karol S, Meyer J, Oosterwiik E, Havrilesky L, Alvarez Secord A, Vujaskovic Z, Dewhirst M, Jones E. Elevated CAIX expression is associated with an increased risk of distant failure in early-stage cervical cancer. Biomark Insights Feb 1;3:45-55, 2008. PMID: 19578493.

Blaser BW, Schwind NR, Karol S, Chang D, Shin S, Roychowdhury S, Becknell B, Ferketich AK, Kusewitt DF, Blazer BR, Caligiuri MA. Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity. Blood Oct 1;108(7):2463-9, 2006. PMID: 16757683.

Nestor AL, Cicila GC, Karol SE, Langenderfer KM, Hollopeter SL, Allison DC. Linkage analysis of neointimal hyperplasia and vascular wall transformation after balloon angioplasty. Physiol Genomics Apr 13;25(2):286-93, 2006. PMID: 16434542.

Last update: October 2016