Motomi Mori
Motomi Mori, PhD, MBA

Motomi Mori, PhD, MBA

Member, St. Jude Faculty

  • Chair, Biostatistics
  • Endowed Chair in Biostatistics

Departments

Education

BA – University of Montana, Missoula, Montana
MS – University of Iowa, Iowa City, Iowa
PhD - University of Iowa, Iowa City, Iowa
MBA – Oregon Health & Science University-Portland State University, Portland, Oregon

Honors & Awards

  • 2020  Award for Outstanding Contribution to the Development of the IBS

Research Interests

  • Basic, translational, clinical and population science

Selected Publications

Zhang Z, Garzotto M, Davis EW 2nd, Mori M, Stoller WA, Farris PE, Wong CP, Beaver LM, Thomas GV, Williams DE, Dashwood RH, Hendrix DA, Ho E, Shannon J. Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. Nutr Cancer Jun 1;1-14, 2019. doi: 10.1080/01635581.2019.1619783. [Epub ahead of print] PubMed PMID: 31155953

Spurgeon SE, Sharma K, Claxton DF, Ehmann C, Pu J, Shimko S, Stewart A, Subbiah N, Palmbach G, LeBlanc F, Latour E, Chen Y, Mori M, Hasanali Z, Epner EM. Phase 1-2 study of vorinostat (SAHA), cladribine and rituximab (SCR) in relapsed B-cell non-Hodgkin lymphoma and previously untreated mantle cell lymphoma. Br J Haematol Jun 9, 2019. doi: 10.1111/bjh.16008. [Epub ahead of print] PubMed PMID: 31177537

Kelley KA, Wieghard N, Chin Y, Potter A, Mori M, Wong MH, Chin K, Tsikitis VL. MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis. Dis Colon Rectum Nov;61(11):1290-1296, 2018. doi: 10.1097/DCR.0000000000001192. PubMed PMID: 30239392; PubMed Central PMCID: PMC6172144

Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DK 5th, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ. Functional genomic landscape of acute myeloid leukaemia. Nature Oct;562(7728):526-531, 2018. doi:10.1038/s41586-018-0623-z. Epub 2018 Oct 17. PubMed PMID: 30333627; PubMed Central PMCID: PMC6280667

Lane RS, Femel J, Breazeale AP, Loo CP, Thibault G, Kaempf A, Mori M, Tsujikawa T, Chang YH, Lund AW. IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. J Exp Med Dec 3;215(12):3057-3074, 2018. doi: 10.1084/jem.20180654. Epub 2018 Oct 31. PubMed PMID: 30381467; PubMed Central PMCID: PMC6279400

Edwards DK 5th, Watanabe-Smith K, Rofelty A, Damnernsawad A, Laderas T, Lamble A, Lind EF, Kaempf A, Mori M, Rosenberg M, d'Almeida A, Long N, Agarwal A, Sweeney DT, Loriaux M, McWeeney SK, Tyner JW. CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells. Blood Feb 7;133(6):588-599, 2019. doi: 10.1182/blood-2018-03-838946. Epub 2018 Nov 13. PubMed PMID: 30425048; PubMed Central PMCID: PMC6367650

Goddard ET, Bassale S, Schedin T, Jindal S, Johnston J, Cabral E, Latour E, Lyons TR, Mori M, Schedin PJ, Borges VF. Association Between Postpartum Breast Cancer Diagnosis and Metastasis and the Clinical Features Underlying Risk. JAMA Netw Open Jan 4;2(1):e186997, 2019. doi: 10.1001/jamanetworkopen.2018.6997. PubMed PMID: 30646210

Kurtz SE, Eide CA, Kaempf A, Mori M, Tognon CE, Borate U, Druker BJ, Tyner JW. Dual inhibition of JAK1/2 kinases and BCL2: a promising therapeutic strategy for acute myeloid leukemia. Leukemia Aug 6, 2018. doi: 10.1038/s41375-018-0225-7. [Epub ahead of print] PubMed PMID: 30082821

Hosseini MM, Kurtz SE, Abdelhamed S, Mahmood S, Davare MA, Kaempf A, Elferich J, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JW, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. Leukemia Mar 29, 2018. doi: 10.1038/s41375-018-0112-2. [Epub ahead of print] PubMed PMID: 29743719

Chen EY, Blanke CD, Haller DG, Benson AB, Dragovich T, Lenz HJ, Robles C, Li H, Mori M, Mattek N, Sanborn RE, Lopez CD. A Phase II Study of Celecoxib With Irinotecan, 5-Fluorouracil, and Leucovorin in Patients With Previously Untreated Advanced or Metastatic Colorectal Cancer. Am J Clin Oncol May 18, 2018. doi:10.1097/COC.0000000000000465. [Epub ahead of print] PubMed PMID: 29782360

Angier H, Huguet N, Marino M, Mori M, Winters-Stone K, Shannon J, Raynor L, Holderness H, DeVoe JE. Assessing Community Cancer care after insurance ExpanSionS (ACCESS) study protocol. Contemp Clin Trials Commun Sep;7:136-140, 2017. doi: 10.1016/j.conctc.2017.06.011. Epub 2017 Jun 24. PubMed PMID: 29473059; PubMed Central PMCID: PMC5819346

Sullivan DR, Mongoue-Tchokote S, Mori M, Goy E, Ganzini L. Randomized, double-blind, placebo-controlled study of methylphenidate for the treatment of depression in SSRI-treated cancer patients receiving palliative care. Psycho-oncology 26(11):1763-1769, 2017. NIHMSID: NIHMS876613 PubMed [journal] PMID: 27429350, PMCID: PMC5509522

Jansen LA, Mahadevan D, Appelbaum PS, Klein WMP, Weinstein ND, Mori M, Degnin C, Sulmasy DP. Variations in Unrealistic Optimism Between Acceptors and Decliners of Early Phase Cancer Trials. Journal of empirical research on human research ethics. JERHRE 12(4):280-288, 2017. PubMed [journal] PMID: 28728498

Jansen LA, Mahadevan D, Appelbaum PS, Klein WMP, Weinstein ND, Mori M, Degnin C, Sulmasy DP. Perceptions of control and unrealistic optimism in early-phase cancer trials. Journal of medical ethics 2017. PubMed [journal] PMID: 28774957

Kurtz SE, Eide CA, Kaempf A, Khanna V, Savage SL, Rofelty A, English I, Ho H, Pandya R, Bolosky WJ, Poon H, Deininger MW, Collins R, Swords RT, Watts J, Pollyea DA, Medeiros BC, Traer E, Tognon CE, Mori M, Druker BJ, Tyner JW. Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies. Proceedings of the National Academy of Sciences of the United States of America 114(36):E7554-E7563, 2017. PubMed [journal] PMID: 28784769, PMCID: PMC5594650

Tsujikawa T, Kumar S, Borkar RN, Azimi V, Thibault G, Chang YH, Balter A, Kawashima R, Choe G, Sauer D, El Rassi E, Clayburgh DR, Kulesz-Martin MF, Lutz ER, Zheng L, Jaffee EM, Leyshock P, Margolin AA, Mori M, Gray JW, Flint PW, Coussens LM. Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis. Cell Rep Apr 4;19(1):203-217, 2017. doi: 10.1016/j.celrep.2017.03.037. PubMed PMID: 28380359

Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P. The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. Cancer Discov Feb;7(2):177-187, 2017. doi: 10.1158/2159-8290.CD-16-0822. Epub 2016 Dec 14. PubMed PMID: 27974414; PubMed Central PMCID: PMC5459606

Hammarlund E, Thomas A, Poore EA, Amanna IJ, Rynko AE, Mori M, Chen Z, Slifka MK. Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. Clin Infect Dis May 1;62(9):1111-8, 2016. doi: 10.1093/cid/ciw066. PubMed PMID: 27060790; PubMed Central PMCID: PMC4826453

Wiedmeier JE, Kato C, Zhang Z, Lee H, Dunlap J, Nutt E, Rattray R, McKay S, Eide C, Press R, Mori M, Druker B, Dao KH. Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women. Exp Hematol Sep;44(9):857-865.e5, 2016. doi:10.1016/j.exphem.2016.05.009. PubMed PMID: 27235757; PubMed Central PMCID: PMC4993458

Tsikitis VL, Potter A, Mori M, Buckmeier JA, Preece CR, Harrington CA, Bartley AN, Bhattacharyya AK, Hamilton SR, Lance MP, Thompson PA. MicroRNA Signatures of Colonic Polyps on Screening and Histology. Cancer Prev Res (Phila) Dec;9(12):942-949, 2016. PubMed PMID: 27658891; PubMed Central PMCID: PMC5136314

Zhang Z, Garzotto M, Beer TM, Thuillier P, Lieberman S, Mori M, Stoller WA, Farris PE, Shannon J. Effects of ω-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial. Nutr Cancer Nov-Dec;68(8):1309-1319, 2016. PubMed PMID: 27646578

Jansen LA, Mahadevan D, Appelbaum PS, Klein WM, Weinstein ND, Mori M, Daffé R, Sulmasy DP. Dispositional optimism and therapeutic expectations in early-phase oncology trials. Cancer Feb 16, 2016. doi: 10.1002/cncr.29908. [Epub ahead of print] PubMed PMID: 26882017

Young JI, Mongoue-Tchokote S, Wieghard N, Mori M, Vaccaro GM, Sheppard BC, Tsikitis VL. Treatment and Survival of Small-bowel Adenocarcinoma in the United States: A Comparison With Colon Cancer. Dis Colon Rectum Apr;59(4):306-15, 2016. doi: 10.1097/DCR.0000000000000562. PubMed PMID: 26953989

Atwell LL, Zhang Z, Mori M, Farris PE, Vetto JT, Naik AM, Oh KY, Thuillier P, Ho E, Shannon J. Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Cancer Prev Res (Phila) Dec;8(12):1184-91, 2015. doi: 10.1158/1940-6207.CAPR-15-0119. PubMed PMID: 26511489; PubMed Central PMCID: PMC4670794

Huan J, Hornick NI, Goloviznina NA, Kamimae-Lanning AN, David LL, Wilmarth PA, Mori T, Chevillet JR, Narla A, Roberts CT Jr, Loriaux MM, Chang BH, Kurre P. Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes. Leukemia Dec;29(12):2285-95, 2015. doi: 10.1038/leu.2015.163. PubMed PMID: 26108689; PubMed Central PMCID: PMC4834971

Alumkal JJ, Slottke R, Schwartzman J, Cherala G, Munar M, Graff JN, Beer TM, Ryan CW, Koop DR, Gibbs A, Gao L, Flamiatos JF, Tucker E, Kleinschmidt, Mori M (2014). A Phase II Study of Sulforaphane-Rich Broccoli Sprout Extracts in Men with Recurrent Prostate Cancer.  Investigational New Drugs Apr;33(2):480-9, 2015. doi: 10.1007/s10637-014-0189-z. Epub 2014 Nov 29.

Liu BY, O’Malley J, Mori M, Fagnan LJ, Lieberman D, Morris CD, Buckley DI, Heintzman JD, Carney PA. The Association of Type and Number of Chronic Diseases with Breast, Cervical, and Colorectal Cancer Screening. Journal of American Board of Family Medicine Sep-Oct;27(5):669-81, 2014. doi: 10.3122/jabfm.2014.05.140005

Le TD, Carney PA, Lee-Lin F, Mori M, Chen Z, Leung H, Lau C, Lieberman DA. Differences in Knowledge, Attitudes, Beliefs, and Perceived Risks Regarding Colorectal Cancer Screening Among Chinese, Korean, and Vietnamese Sub-Groups. Journal of Community Health 39(2):248-265, 2014.

Carney PA, Lee Lin F, Mongoue-Tchokote S, Mori M, Leung H, Lau C, Le TD, Lieberman D. Improving Colorectal Cancer Screening in Asian Americans:  Results of a Randomized Trial. Cancer 120(11):1702-1712, 2014.

Tsikitis VL, White I, Mori M, Potter A, Bhattcharyya A, Hamilton SR, Buckmeier J, Lance P, Thompson P. Differential Expression of MicroRNA-320a, -145, and -192 Among the Continuum of Normal Mucosa to High-Grade Dysplastic Adenoma of the Colorectum. American Journal of Surgery 207(5):717-722, 2014.

Backus D, Cordo P, Gillott A, Kandilakis C, Mori M, Rasian AM. Assisted Movement With Proprioceptive Stimulation Reduces Impairment and Restores Function in Incomplete Spinal Cord Injury. Archives of Physical Medicine and Rehabilitation 95:1447-1453, 2014.

Meserve E, Berlin M, Mori T, Krum R, Morgan TK. Reducing Misclassification Bias in Cervical Dysplasia Risk Factor Analysis with P16-based Diagnoses. Journal of Lower Genital Tract Disease 18(3):266-272, 2014.

Last update: March 2020

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