Yadav Sapkota, PhD

Yadav Sapkota, PhD

  • Clinical Research Scientist

Departments

Education

BSc – Tribhuvan University, Kathmandu, Nepal [2000]
MSc – Vrije University Brussels (Molecular Biology and Biotechnology), Brussels, Belgium [2002]
MSc – Catholic University Leuven (Bioinformatics), Leuven, Belgium [2003]
PhD – University of Alberta, Edmonton, Canada [2013]

Research Interests

  • Complex trait genetics
  • Genetics of late effects in childhood cancer survivors
  • Statistical genetics

Selected Publications

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y,……., Franke L, Reymond A, Frayling TM, Kutalik Z. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun 2017 (in press).

Sapkota Y*, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, Buring JE, Zhang F, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, MacGregor S, Martin NG, Becker CM, Adachi S, Yoshihara K, Enomoto  T, Takahashi A, Kamatani Y, Matsuda K, Kubo M, Thorleifsson G, Geirsson RT, Thorsteinsdottir U, Wallace LM; iPSYCH-SSI-Broad Group, Yang J, Velez Edwards DR, Nyegaard M, Low SK, Zondervan KT, Missmer SA, D'Hooghe T, Montgomery GW, Chasman  DI, Stefansson K, Tung JY, Nyholt DR. Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. Nat Commun May 24;8:15539, 2017. PMID: 28537267. *Corresponding author

Haycock PC, Burgess S, Nounu  A, Zheng J, Okoli GN, Bowden J, ….., Sapkota  Y, ….., Lin K, Powell JF, Rice K, Relton CL, Martin  RM, Davey Smith G. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol May 1;3(5):636-651, 2017. PMID: 28241208.

 

Powell JE, Fung JN, Shakhbazov K, Sapkota Y, Cloonan N, Hemani G, Hillman KM,  Kaufmann S, Luong HT, Bowdler L, Painter JN, Holdsworth-Carson SJ, Visscher PM, Dinger ME, Healey M, Nyholt DR, French JD, Edwards SL, Rogers PA, Montgomery GW.  Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339. Hum Mol Genet Nov 15;25(22):5046-5058, 2016. PMID: 28171565.

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, ….., Sapkota Y, ….., Rivadeneira F, Loos RJ, Frayling TM, Hirschhorn JN, Deloukas P, Lettre G. Rare and low-frequency coding variants alter human adult height. Nature Feb 9;542(7640):186-190, 2017. PMID: 28146470.

Sapkota Y, Narasimhan A, Kumaran M, Sehrawat BS, Damaraju S. A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility. Cytogenet Genome Res 149(3):156-164, 2016. PMID: 27668787.

Sapkota Y*, Fassbender A, Bowdler L, Fung JN, Peterse D, O D, Montgomery GW, Nyholt DR, D'Hooghe TM. Independent Replication and Meta-Analysis for Endometriosis Risk Loci. Twin Res Hum Genet Oct;18(5):518-25, 2015. PMID: 26337243. *Corresponding author

Sapkota Y*, Attia J, Gordon SD, Henders AK, Holliday EG, Rahmioglu N, MacGregor S, Martin NG, McEvoy M, Morris AP, Scott RJ, Zondervan KT, Montgomery GW, Nyholt  DR. Genetic burden associated with varying degrees of disease severity in endometriosis. Mol Hum Reprod Jul;21(7):594-602, 2015. PMID: 25882541. *Corresponding author

Sapkota Y*. Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature. Cytogenet Genome Res 144(2):77-91, 2014. Review. PMID: 25401968. *Sole author

Sapkota Y*, Low SK, Attia J, Gordon SD, Henders AK, Holliday EG, MacGregor S,  Martin NG, McEvoy M, Morris AP, Takahashi A, Scott RJ, Kubo M, Zondervan KT, Montgomery GW, Nyholt DR. Association between endometriosis and the interleukin 1A (IL1A) locus. Hum Reprod Jan;30(1):239-48, 2015. PMID: 25336714. *Corresponding author

Sapkota Y, Mackey JR, Lai R, Franco-Villalobos C, Lupichuk S, Robson PJ, Kopciuk K, Cass CE, Yasui Y, Damaraju S. Assessing SNP-SNP interactions among DNA repair, modification and metabolism related pathway genes in breast cancer susceptibility. PLoS One Jun 3;8(6):e64896, 2013. PMID: 23755158.

Sapkota Y, Yasui Y, Lai R, Sridharan M, Robson PJ, Cass CE, Mackey JR, Damaraju S. Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm. PLoS One May 22;8(5):e62550, 2013. PMID: 23717390.

Sapkota Y, Ghosh S, Lai R, Coe BP, Cass CE, Yasui Y, Mackey JR, Damaraju S. Germline DNA copy number aberrations identified as potential prognostic factors for breast cancer recurrence. PLoS One 8(1):e53850, 2013. PMID: 23342018.

Sapkota Y, Robson P, Lai R, Cass CE, Mackey JR, Damaraju S. A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility. Eur J Hum Genet Jun;20(6):682-9, 2012. PMID:  22258532.

Last update: July 2017