Selected Publications
Zoine JT, Immadisetty K, Ibanez-Vega J, Moore SE, Nevitt C, Thanekar U, Tian L, Karouni A, Chockley PJ, Arthur B, Sheppard H, Klco JM, Langfitt DM, Krenciute G, Gottschalk S, Babu MM, Velasquez MP. Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity. Cell Rep Med Feb 20;5(2):101422. doi: 10.1016/j.xcrm.2024.101422. Epub 2024.
Ibanez J, Hebbar N, Thanekar U, Yi Z, Houke H, Ward M, Nevitt C, Tian L, Mack SC, Sheppard H, Chiang J, Velasquez MP, Krenciute G. GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells. Cell Rep Med Nov 21;4(11):101297. doi: 10.1016/j.xcrm.2023.101297. 2023.
Park CS, Yoshihara H, Gao Q, Qu C, Iacobucci I, Ghate PS, Connelly JP, Pruett-Miller SM, Wagner B, Robinson CG, Mishra A, Peng J, Yang L, Rankovic Z, Finkelstein D, Luger S, Litzow M, Paietta EM, Hebbar N, Velasquez MP, Mullighan CG. Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia. Cell Rep Jul 25;42(7):112804. doi: 10.1016/j.celrep.2023.112804. Epub 2023.
Kim-Hoehamer YI, Riberdy JM, Zheng F, Park JJ, Shang N, Métais JY, Lockey T, Willis C, Akel S, Moore J, Meagher MM, Velasquez MP, Triplett BM, Talleur AC, Gottschalk S, Zhou S. Development of a cGMP-compliant process to manufacture donor-derived, CD45RA-depleted memory CD19-CAR T cells. Gene Ther Apr;30(3-4):222-231. doi: 10.1038/s41434-021-00307-0. Epub 2022.
Vaidya A, Doherty E, Wu X, Huang S, Hebbar N, Thanekar U, Bonifant CL, Cheng C, Gottschalk S, Velasquez MP. Improving the anti-acute myeloid leukemia activity of CD123-specific engager T cells by MyD88 and CD40 costimulation. Haematologica Apr 1;108(4):1039-1052. doi: 10.3324/haematol.2021.279301. 2023.
Velasquez MP. Allogeneic CD7-CAR T cells to bridge the gap?. Transplant Cell Ther Mar;29(3):139-140. doi: 10.1016/j.jtct.2023.02.006. 2023.
Pfeiffer T, Li Y, Ashcraft E, Karol SE, Rubnitz JE, Epperly R, Madden R, Mamcarz E, Obeng E, Qudeimat A, Sharma A, Srinivasan A, Suliman A, Talleur AC, Velasquez MP, Gottschalk S, Triplett BM, Naik S. Venetoclax-based therapy as a bridge to allogeneic hematopoietic cell transplantation in children with relapsed/refractory AML. Bone Marrow Transplant Mar;58(3):328-331. doi: 10.1038/s41409-022-01877-2. Epub 2022.
Freiwan A, Zoine JT, Crawford JC, Vaidya A, Schattgen SA, Myers JA, Patil SL, Khanlari M, Inaba H, Klco JM, Mullighan CG, Krenciute G, Chockley PJ, Naik S, Langfitt DM, Mamonkin M, Obeng EA, Thomas PG, Gottschalk S, Velasquez MP. Engineering naturally occurring CD7- T cells for the immunotherapy of hematological malignancies. Blood Dec 22;140(25):2684-2696. doi: 10.1182/blood.2021015020. 2022.
Talleur AC, Qudeimat A, Métais JY, Langfitt D, Mamcarz E, Crawford JC, Huang S, Cheng C, Hurley C, Madden R, Sharma A, Suliman A, Srinivasan A, Velasquez MP, Obeng EA, Willis C, Akel S, Karol SE, Inaba H, Bragg A, Zheng W, Zhou SM, Schell S, Tuggle-Brown M, Cullins D, Patil SL, Li Y, Thomas PG, Zebley C, Youngblood B, Pui CH, Lockey T, Geiger TL, Meagher MM, Triplett BM, Gottschalk S. Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL. Blood Adv Nov 8;6(21):5737-5749. doi: 10.1182/bloodadvances.2021006293. 2022.
Wilson TL, Kim H, Chou CH, Langfitt D, Mettelman RC, Minervina AA, Allen EK, Métais JY, Pogorelyy MV, Riberdy JM, Velasquez MP, Kottapalli P, Trivedi S, Olsen SR, Lockey T, Willis C, Meagher MM, Triplett BM, Talleur AC, Gottschalk S, Crawford JC, Thomas PG. Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages. Cancer Discov Sep 2;12(9):2098-2119. doi: 10.1158/2159-8290.CD-21-1508. 2022.
Velasquez MP, Mamonkin M. CD7 CAR: sword and shield. Blood. Jul 28;140(4):293-294. doi: 10.1182/blood.2022016595. 2022.
Mu-Mosley H, Ostermann L, Muftuoglu M, Vaidya A, Bonifant CL, Velasquez MP, Gottschalk S, Andreeff M. Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models. Front Immunol 2022;13:880108. doi: 10.3389/fimmu.2022.880108. eCollection 2022.
Zoine JT, Moore SE, Velasquez MP. Leukemia's Next Top Model? Syngeneic Models to Advance Adoptive Cellular Therapy. Front Immunol 2022;13:867103. doi: 10.3389/fimmu.2022.867103. eCollection 2022.
Hebbar N, Epperly R, Vaidya A, Thanekar U, Moore SE, Umeda M, Ma J, Patil SL, Langfitt D, Huang S, Cheng C, Klco JM, Gottschalk S, Velasquez MP. CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells. Nature Communications Jan 31;13:587, 2022.
Kim-Hoehamer Y-I, Riberdy JM, Zheng F, Park JJ, Shang N, Métais J-Y, Lockey T, Willis C, Akel S, Moore J, Meagher MM, Velasquez MP, Triplett BM, Talleur AC, Gottschalk S, Zhou S.Development of a cGMP-compliant process to manufacture donor-derived, CD45RA-depleted memory CD19-CAR T cells. Gene Ther Online ahead of print. Jan 8, 2022.
Schreiner P, Velasquez MP, Gottschalk S, Zhang J, Fan Y. Unifying heterogeneous expression data to predict targets for CAR-T cell therapy. OncoImmunology Nov 14;10(1), 2021.
Epperly R, Gottschalk S, Velasquez MP. A bump in the road: How the hostile AML microenvironment affects CAR T cell therapy. Front Oncol Feb 28, 10:262, 2020. doi: 10.3389/fonc.2020.00262. eCollection 2020.
Riberdy JM, Zhou S, Zheng F, Kim YI, Moore J, Vaidya A, Throm RE, Sykes A, Sahr N, Bonifant CL, Ryu B, Gottschalk S, Velasquez MP. The art and science of selecting a CD123-specific chimeric antigen receptor for clinical testing. Mol Ther Methods Clin Dev Jun 30;18:571-581, 2020. doi: 10.1016/j.omtm.2020.06.024. eCollection Sep 11, 2020.
Epperly R, Gottschalk S, Velasquez MP. Harnessing T cells to target pediatric acute myeloid leukemia: CARs, BiTEs, and beyond. Children (Basel) Feb 17;7(2):14, 2020. doi: 10.3390/children7020014.
Velasquez MP, Bonifant CL, Gottschalk S. Redirecting T cells to hematological malignancies with bispecific antibodies. Blood Jan 4;131(1):30-38, 2018. doi: 10.1182/blood-2017-06-741058. Epub Nov 8, 2017.
Bonifant CL, Velasquez MP, Gottschalk S. Advances in immunotherapy for pediatric acute myeloid leukemia. Expert Opin Biol Ther Jan;18(1):51-63, 2018. doi: 10.1080/14712598.2018.1384463. Epub Oct 11, 2017.
Szoor A, Vaidya A, Velasquez MP, Mei Z, Galvan DL, Torres DT, Gee A, Heczey A, Gottschalk S. T-cell activating Mesenchymal Stem Cells as a Biotherapeutic for HCC. Mol Ther Oncolytics Sept 2017.
Velasquez MP, Szoor A, Vaidya A, Thakkar A, Nguyen P, Wu M-F, Liu H, Gottschalk S. CD28 and 41BB costimulation enhances the effector function of CD19-specific Engager T cells. Cancer Immunol Res Aug 18, 2017. [Epub ahead of print]
Bonifant CL, Torres, D, Joseph N, Velasquez MP, Szoor A, Iwahori K, Gaikwad A, Nguyen P, Arber C, Song XT, Redell M, Gottschalk S. CD123 Engager T cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Molecular Therapy 24(9):1615-26, 2016. doi: 10.1038/mt.2016.116
Velasquez MP, Torres D, Iwahori K, Kakarla S, Arber C, Rodriquez-Cruz T, Szoor a, Bonifant CL, Gerken C, Cooper LJN, Song XT, Gottschalk S. T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies. Sci Rep 6:27130, 2016. doi: 10.1038/srep27130
Iwahori K, Kakarla S, Velasquez MP, Yu F, Yi Z, Gerken C, Song X, Gottschalk S. Engager T cells: A new class of antigen-specific T cells that redirect bystander T cells. Molecular Therapy 23(1):171-8. doi: 10.1038/mt.2014.156
Crabtree E, Mariscalco M, Hesselgrave J, Iniguez SF, Hilliard TJ, Katkin JP, McCarthy K, Velasquez MP, Airewele G, Hockenberry MJ. Improving Care for Children with Sickle Cell Disease/ Acute Chest Syndrome. Pediatrics 127(2):e480-8. doi: 10.1542/peds.2010-3099
Velasquez MP, Mariscalco M, Goldstein S, Airewele G. Erythrocytapheresis in children with sickle cell disease and acute chest syndrome. Pediatric Blood and Cancer 53(6):1060-1063, 2009.
Velasquez MP, Moyer Va. Weighing the Evidence: Clinical Practice Guidelines. AAP Grand Rounds 20:51, 2008.
Last update: July 2024