Mitchell Weiss, MD, PhD
Mitchell J. Weiss, MD, PhD

Mitchell J. Weiss, MD, PhD

Member, St. Jude Faculty

  • Chair, Hematology Department
  • Arthur Nienhuis Endowed Chair in Hematology

Departments

Education

BS – The Pennsylvania State University
MD, PhD – University of Pennsylvania

Honors & Awards

  • 2014 William Hathaway Visiting Professor, University of Colorado Denver Department of Pediatrics
  • 2012 Association of American Physicians (AAP)
  • 2008 Society for Pediatric Research (SPR)
  • 2006 Leukemia and Lymphoma Society Career Development Award
  • 2003 Hummler Research Prize, The Children's Hospital of Philadelphia
  • 1983 Alpha Omega Alpha Honor Society

Research Interests

  • Mechanisms of gene expression during blood cell development
  • Non-coding RNAs in red blood cell formation, including microRNAs and long non-coding RNAs
  • Use of induced pluripotent stem cells to model human blood disorders including leukemia
  • Structure and biology of hemoglobins
  • Role of ubiquitin ligases in red blood cell development

Selected Publications

Ren B,…Weiss MJ,…et al, for the Mouse ENCODE Consortium. A comparative encyclopedia of DNA elements in the mouse genome. Nature 515(7527):355-64, 2014. 

Wu W, Morrissey CS, Keller CA, Mishra T, Pimkin M, Blobel GA, Weiss MJ, Hardison RC. Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis. Genome Res October 15, 2014. Epub ahead of print. PMID: 25319994.

Ranjan R, Lee YG, Karpurapu M, Syed MA, Chung S, Deng J, Jeong JJ, Zhao G, Xiao L, Sadikot RT, Weiss MJ, Christman JW, Park GY. P47 phox and reactive oxygen species production modulate expression of microRNA-451 in macrophages. Free Radic Res October 30, 2014. Epub ahead of print. PMID: 25287330.

Pimkin M, Kossenkov AV, Mishra T, Morrissey CS, Wu W, Keller CA, Blobel GA, Lee D, Beer MA, Hardison RC, Weiss MJ. Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. Genome Res October 15, 2014. Epub ahead of print. PMID: 25319996.

Betensky M, Witmer C, Fisher MJ, Nance S, Weiss MJ, Sesok-Pizzini DA. Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. Transfusion May 27, 2014. Epub ahead of print. PMID: 24860959.

Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva APG, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur ELF, Weiss MJ. Trim58 degrades dynein and regulates terminal erythropoiesis. Dev Cell 20;30(6):688-700, 2014. PMID: 25241935.

Nothnick WB, Graham A, Holbert J, Weiss MJ. miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model. PLoS One 9(6):e100336, 2014. PMCID: PMC4061076.

Strader MD, Hicks WA, Kassa T, Singleton E, Soman J, Olson JS, Weiss MJ, Mollan TL, Wilson MT, Alayash AI. Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: A novel subunit-specific mechanism in hemoglobin. J Biol Chem 289(32):22342-57, 2014. PMID: 24939847.

Paralkar VR, Mishra T, Luan J, Yao Y, Kossenkov AV, Anderson SM, Dunagin M, Pimkin M, Gore M, Sun D, Konuthula N, Raj A, An X, Mohandas N, Bodine DM, Hardison RC, Weiss MJ. Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood 123(12):1927-1937, 2014. PMCID: PMC3962165.

King RL, Weiss MJ. Iron-laden macrophage in autoimmune disease. Blood 123(4):469, 2014. PMID: 24605366.

Garçon L, Ge J, Manjunath SH, Mills JA, Apicella M, Parikh S, Sullivan LM, Podsakoff GM, Gadue P, French DL, Mason PJ, Bessler M, Weiss MJ. Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients. Blood 122(6):912-921, 2013. PMCID: PMC3739037.

Dickson CF, Rich AM, D'Avigdor WMH, Collins DAT, Lowry JA, Mollan TL, Khandros E, Olson JS, Weiss MJ, Mackay JP, Lay PA, Gell DA. α-hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond. J Biol Chem 288(27):19986-20001, 2013. PMCID: PMC3707698.

Gandre-Babbe S, Paluru P, Aribeana C, Chou ST, Bresolin S, Lu L, Sullivan SK, Tasian SK, Weng J, Favre H, Choi JK, French DL, Loh ML, Weiss MJ. Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. Blood 121(24):4925-4929, 2013. PMCID: PMC3682343.

Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M,Weiss MJ, Kahn ML. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood 121(16):3228-3236, 2013. PMCID: PMC3655737

Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek K-H, Aird WC, Weiss MJ, Ryeom S. The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood 121(16):3205-3215, 2013. PMCID: PMC3630833.

Mollan TL, Banerjee S, Wu G, Parker Siburt CJ, Tsai A-L, Olson JS, Weiss MJ, Crumbliss AL, Alayash AI. Alpha-hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha subunits of human HbA with hydrogen peroxide. J Biol Chem 288(6):4288-4298, 2012. PMCID: PMC3567680.

Rosenberger CM, Podyminogin RL, Navarro G, Zhao G-W, Askovich PS, Weiss MJ, Aderem A. miR-451 regulates dendritic cell cytokine responses to influenza infection. J Immunol 189(12):5965-5975, 2012. PMCID: PMC3528339.

Roy A, Cowan G, Mead AJ, Filippi S, Bohn G, Chaidos A, Tunstall O, Chan JKY, Choolani M, Bennett P, Kumar S, Atkinson D, Wyatt-Ashmead J, Hu M, Stumpf MPH, Goudevenou K, O'Connor D, Chou ST, Weiss MJ, Karadimitris A, Jacobsen SE, Vyas P, Roberts I. Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc Natl Acad Sci USA 109(43):17579-17584, 2012. PMCID: PMC3491522.

Raess PW, Paessler ME, Bagg A, Weiss MJ, Choi JK. α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors. Am J Surg Pathol 36(10):1538-1547, 2012. PMCID: PMC3445287

Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, Mills JA, Choi JK, Speck NA, Gadue P, Hardison RC, Nemiroff RL, French DL, Weiss MJ. Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proc Natl Acad Sci U S A109(43):17573-17578, 2012. PMCID: PMC3491490

Stamatoyannopoulos JA,… [Weiss MJ],… Adams LB. An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol 13(8):418, 2012. PMCID: PMC3491367

Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HFG, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS. SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.Blood 120(2):404-414, 2012. PMCID: PMC3398753

Chung EY, Psathas JN, Yu D, Li Y, Weiss MJ, Thomas-Tikhonenko A. CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest 122(6):2257-2266, 2012. PMCID: PMC3366393

Wang X, Zhu H, Zhang X, Liu Y, Chen J, Medvedovic M, Li H, Weiss MJ, Ren X, Fan G-C. Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1. Cardiovasc Res 94(2):379-390, 2012. PMCID: PMC3331614

Khandros E, Thom CS, D'Souza J, Weiss MJ. Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood 119(22):5265-5275, 2012. PMCID: PMC3369615

Cheng X, Ying L, Lu L, Galvão AM, Mills JA, Lin HC, Kotton DN, Shen SS, Nostro MC, Choi JK,Weiss MJ, French DL, Gadue P. Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell Stem Cell 10(4):371-384, 2012. PMCID: PMC3580854

Mollan TL, Khandros E, Weiss MJ, Olson JS. Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. J Biol Chem287(14):11338-11350, 2012. PMCID: PMC3322864

Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ. Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein. J Biol Chem287(14):11325-11337, 2012. PMCID: PMC3322894

Manavathi B, Lo D, Bugide S, Dey O, Imren S, Weiss MJ, Humphries RK. Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation. J Biol Chem 287(8):5600-5614, 2012. PMCID: PMC3285334

Last update: November 2014