Jun J. Yang, PhD
Jun J. Yang, PhD

Education

PhD – Purdue University, West Lafayette, Indiana (2006)

Research Interests

My primary research interest is to understand genetic basis of inter-patient variability in anticancer drug response, with particular focus on the following aspects of pharmacogenomics of childhood cancer:

  • Pharmacogenomics of anti-leukemia drug toxicities
  • Genomics of anti-leukemia drug sensitivity and resistance (especially molecularly targeted therapeutics)
  • Influence of germline genomics on pediatric cancer susceptibility and treatment outcomes

Selected Publications

Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ. Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. PNAS. Mar 10;117(10):5394 5401, 2020. PMCID: PMC7071893.

Vijayakrishnan J, Qian M, Studd BJB, Yang W, Kinnersley B, Law PJ, Broderick P, Raetz EA, Allan J, Pui CH, Vora A, Evans WE, Moorman A, Yeoh A, Yang W, Li C, Bartram CR, Mullighan CG, Zimmerman M, Hunger SP, Schrappe M, Relling MV, Stanulla M, Loh ML, Houslton RS, Yang JJ. Identification of 1 four novel associations for B-cell acute lymphoblastic leukaemia risk. Nature Communications. Nov 25;10(1):5348, 2019. PMCID: PMC6877561. 

Li B, Brady SW, Ma X, Shen S, Zhang Y, Lu Y, Szlachta K, Dong L, Liu Y, Yang F, Wang N, Flasch DA, Myers MA, Mulder HL, Ding L, Tian L, Hagiwara K, Xu K, Zhou X, Sioson E, Wang T, Yang L, Zhao J, Zhang H, Shao Y, Sun H, Sun L, Cai J, Sun HY, Lin TN, Du L, Li H, Rusch M, Edmonson MN, Easton J, Zhu X, Zhang J, Cheng C, Raphael BR, Tang J, Sowning JR, Alexandrov LB, Zhou BS, Pui CH, Yang JJ*, Zhang J. Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood. Oct 24, 2019. pii: blood.2019002220. PMID: 31697823. (*co-corresponding author)

Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui CH, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang JJ. Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children. J Natl Cancer Inst. Apr 2, 2019. Epub ahead of print. PMID: 30938820.

Yang JJ, Whirl-Carrillo M, Scott SA, Turner AJ, Schwab M, Tanaka Y, Suarez-Kurtz G, Schaeffeler E, Klein TE, Miller NA, Gaedigk A. Pharmacogene Variation Consortium Gene Introduction: NUDT15. Clin Pharmacol Ther. Dec 4, 2018. Epub ahead of print. PMID: 30515762.

Qian M, Xu H, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood. Dec 3, 2018. Epub ahead of print. PMID:30510082.

Churchman ML, Qian M, Zhang R, Kronnie G, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Devidas M, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Mardis ER, Fulton RS, Stanulla M, Evans WE, Relling MV, Pui CH, Handgretinger R, Hunger SP, Loh ML, Nichols KE, Mullighan C, and Yang JJ*. Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell. Apr 16, 2018. Epub ahead of print. PMID: 29681510. 

Nishii R, Moriyama T, Janke L, Yang W, Suiter C, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Katsuyoshi K, Yeoh AE, Hori H, Yang J*. Effects of NUDT15 genotype-guided treatment individualization on thiopurine toxicity and anti-leukemic efficacy. Blood. Mar 23, 2018. Epub ahead of print. PMID: 29572377.

Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnizda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang QF, Yang JJ*, Zhu X*, and Liu X*. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. Blood. Feb 6, 2018. Epub ahead of print. PMID: 29434033. (*co-corresponding authors)

Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema N, Zhang H, Moriyama T, Gastier-Foster J, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, and Yang JJ*. TP53 germline variations influence the predisposition and prognosis of B-cell acute lymphoblastic leukemia in children. J Clin Oncol. Feb 20;36(6), 591-599, 2018. Epub Jan 4, 2018. PMCID: PMC5815403.

Moriyama T, Yang YL, Arrifin H, Nishii R, Lin TN, Liu C, Yang W, Lin DT, Yu CH, Kham S, Pui C-H, Evans WE, Jeha S, Relling MV, Yeoh A, Yang JJ*. Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry. Blood. Sep 7; 130(10): 1209-1212, 2017. Epub June 28, 2017. PMCID: PMC5606007.

Hu S, Qian M, Zhang H, Guo Y, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan A-M, Cheng Y, Li C, Yeoh AE, Pui C-H, Skanderup AJ, Yang JJ*. Whole-genome non-coding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood. Jun 15; 129(24): 3264-3268, 2017. Epub Apr 13, 2017 PMCID: PMC5472902.

Qian M, Zhang H, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, Yeoh AE, and Yang JJ*. Whole transcriptome sequencing identified a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP. Genome Res. Feb; 27(2): 185-195, 2017. Epub Nov 30, 2016. PMCID: PMC5287225.

Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, Lin T-N, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham S, Isobe T, Chen Z, Chiew E, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui C-H, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AEJ, Evans WE, and Yang JJ*NUDT15 Polymorphisms Alter Thiopurine Metabolism and Hematopoietic Toxicity. Nat Genet. Apr; 48(4):367-73, 2016. PMCID: PMC5029084. 

Moriyama T, Metzger ML, Wu, G, Nishii, R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster J, Raetz E, Larsen E, Martin PL, Bowman WP,  Winick N, Komada Y, Wang S, Edmonson M, Xu H, Mardis E, Fulton R, Pui C-H, Mullighan C, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ*. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. Lancet Oncol. Dec;16(16):1659-66, 2015. PMCID: PMC4684709.

Xu H, Zhang H, Yang W, Yadav R, Morrison AC, Qian M, Devidas M, Liu Y, Perez-Andreu V, Zhao X, Gastier-Foster JM, Lupo PJ, Neale G, Raetz E, Larsen E, Bowman WP, Carroll WL, Winick N, Williams R, Hansen T, Holm J-C, Mardis E, Fulton R, Pui C-H, Zhang J, Mullighan CG, Evans WE, Hunger SP, Gupta R, Schmiegelow K, Loh ML, Relling MV, Yang JJ*.  Inherited Coding Variants at the CDKN2A Locus Influence Susceptibility to Acute Lymphoblastic Leukemia in Children. Nat Commun.  Jun 24; 6:7553, 2015; doi: 10.1038/ncomms8553. PMCID: PMC4544058. 

Xu H, Robinson GW, Huang J, Lim JY, Zhang H, Bass JK, Broniscer A2, Chintagumpala M, Bartels U, Gururangan S, Hassall T, Fisher M, Cohn R, Yamashita T, Teitz T, Zuo J, Onar-Thomas A, Gajjar A, Stewart CF, Yang JJ*.  Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss. Nat Genet. Mar; 47 (3):263-6, 2015. PMCID: PMC4358157. 

Yang JJ*, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay NM, Wong FL, Evans WE, Pui C-H, Bhatia S, and Relling MV. Inherited NUDT15 Variant is a Genetic Determinant of Mercaptopurine Intolerance in Children with Acute Lymphoblastic Leukemia. J Clin Oncol. Apr 10;33(11):1235-42, 2015. PMCID: PMC4375304.

Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier-Foster J, E S, Lim JY, Chen IM, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Klussmann FA, Villagran CR, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui CH, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ*. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet. 45(12):1494-8, 2013. PMCID: PMC4039076.

Yang JJ*, Lim JY, Huang J, Bass JK, Wu J, Wang C, Fang J, Stewart E, Harstead EH, E.Shuyu, Robinson GW, Evans WE, Pappo A, Zuo J, Relling MV, Onar-Thomas A, Gajjar A, Stewart CF. The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer. Clin Pharmacol Ther. 94(2):252-9, 2013. PMCID: PMC3883563

Xu H*, Yang W*, Pérez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG,  Dean M, Winick NJ, Martin PL, Camitta BM, Bowman P, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui CH, Evans WE, Relling MV, Loh M and Yang JJ. Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst. 105(10):733-42, 2013. PMCID: PMC3691938.

Yang JJ*, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox NJ, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui C-H, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet. 43(3):237-241, 2011. PMCID: PMC3104508.

Yang JJ*, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds S, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui C, Devidas M, Bowman WP, Camitta BM, Willman C, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, Relling MV. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA 301(4):393-403, 2009. PMCID: PMC2664534. 

See full list of publications

Last update: August 2020

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