Laura Janke, DVM, PhD
Laura Janke, DVM, PhD, DACVP

Laura Janke, DVM, PhD, DACVP

Associate Member, St. Jude Faculty

Departments

Education

BA – Concordia College, Moorhead, Minnesota (1996)
PhD – University of Minnesota, St.Paul, MN (2004)
DVM – University of Minnesota, College of Veterinary Medicine, St. Paul, MN (2006)
ACVP, Diplomate – University of Minnesota, Veterinary Diagnostic Laboratory, St. Paul, MN (2009)

Research Interests

  • Phenotyping of genetically engineered mice
  • Assessment of treatment efficacy and toxicity in mouse models of pediatric cancers
  • Use of immunohistochemistry to aid in the investigation of tissue- and cell-specific molecular changes
  • Use of histomorphometry and whole slide imaging to assist in the generation of objective data regarding histopathological lesions or antigen expression

Selected Publications

Janke LJ, Van Driest SL, Portera MV, Atreya RV, Denny JC, Pei D, Cheng C, Kaste SC, Inaba H, Jeha S, Pui CH, Relling MV, Karol SE. Hypertension is a modifiable risk-factor for osteonecrosis in acute lymphoblastic leukemia. Blood Aug 13, 2019. pii: blood.2019000006. doi: 10.1182/blood.2019000006. [Epub ahead of print]

Janke LJ, Mullighan CG, Dang J, Rehg JE. Immunophenotyping of murine precursor B-cell leukemia/lymphoma: a comparison of immunohistochemistry and flow cytometry. Vet Pathol Jun 6, 2019: 300985819852138. doi: 10.1177/0300985819852138. [Epub ahead of print]

Finch E, Janke LJ, Smith C, Karol S, Pei D, Cheng C, Kaste S, Inaba H, Pui CH, Wolf J, Relling MV. Blood-borne infections exacerbate incidence and severity of glucocorticoid-induced osteonecrosis. Pediatric Blood & Cancer Jun;66(6):e27669. 2019.

Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG. Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nat Genet Apr; 51(4):694-704, 2019.

Janke LJ, Ward JM, and Vogel P.  Classification, scoring, and quantification of cell death in tissue sections. Vet Pathol Jan;56(1) 33-38, 2019.

Alexander TB, Gu Z, Iacobucci I, Dickerson K, Choi JK, Xu B, Payne-Turner D, Yoshihara H, Loh ML, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Catchpoole D, Hori H, Moorman A, Moore AS, Hrusak O, Meshinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carrol A, Yang YL, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Valentine M, Janke LJ, Rubnitz JE, Pui CH, Ding L, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Newman S, Pei D, Guidry Auvil JM, Gerhard DS, Hunger SP, Inaba H, Mullighan CG. The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature Oct;562(7727):373-379, 2018.

Harwood FC, Klein Geltink RI, O’Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, and Grosveld GC. ETV7 is an essential component of a rapamycin insensitive mTOR complex in cancer. Sci Adv Sep 12;4(9):eaar3938, 2018.

Roberts KG, Janke LJ, Zhao Y, Seth A, Ma J, Finkelstein D, Smith S, Ebata K, Tuch BB, Hunger SP, Mullighan CG. ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition. Blood Aug 23;132(8):861-865, 2018.

Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD. Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis. JCI Insight 2(15):e92409, 2017.

Iacobucci I, Li Y, Roberts KG, Dobson SM, Kim JC, Payne-Turner D, Harvey RC, Valentine M, McCastlain K, Easton J, Yergeau D, Janke LJ, Shao Y, Chen IM, Rusch M, Zandi S, Kornblau SM, Konopleva M, Jabbour E, Paietta EM, Rowe JM, Pui CH, Gastier-Foster J, Gu Z, Reshmi S, Loh ML, Racevskis J, Tallman MS, Wiernik PH, Litzow MR, Willman CL, McPherson JD, Downing JR, Zhang J, Dick JE, Hunger SP, Mullighan CG. Truncating rearrangements of the erythropoietin receptor in acute lymphoblastic leukemia. Cancer Cell Feb 8;29(2):186-200, 2016.

Dang J, Wei L, de Ridder J, Su X, Rust AG, Roberts KG, Payne-Turner D, Cheng J, Ma J, Qu C, Wu G, Song G, Huether RG, Schulman B, Janke L, Zhang J, Downing JR, van der Weyden L, Adams DJ, Mullighan CG. Pax5 is a haploinsufficient tumor suppressor in mouse models of acute lymphoblastic leukemia. Blood April 8, 2015. Epub ahead of print. doi:10.1182/blood-2015-02-626127.

Dang J, Wei L, de Ridder J, Su X, Rust AG, Roberts KG, Payne-Turner D, Cheng J, Ma J, Qu C, Wu G, Song G, Huether RG, Schulman B, Janke L, Zhang J, Downing JR, van der Weyden L, Adams DJ, Mullighan CG. Pax5 is a haploinsufficient tumor suppressor in mouse models of acute lymphoblastic leukemia, Blood Jun 4;125(23):3609-17, 2015.

Pabla N, Gibson AA, Buege M, Ong SS, Li L, Hu S, Du G, Sprowl JA, Vasilyeva A, Janke LJ, Schlatter E, Chen T, Ciarimboli G, Sparreboom A. Mitigation of acute kidney injury by cell cycle inhibitors that suppress both CDK4/6 and OCT2 functions. Proc Natl Acad Sci USA 112(16):5231-6, 2015.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong Y, Janke LJ, Kelliher MA, Kanneganti T, Green DR.  RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3. Cell May 22;157(5):1189-202, 2014.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong Y, Janke LJ, Kelliher MA, Kanneganti T, Green DR.  RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3. Cell 157(5):1189-202, 2014.

Ramsey LB, Janke LJ, Edick MJ, Cheng C, Williams RT, Sherr CJ, Evans WE, Relling MV. Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model. Pharmacogenet Genomics 24(5):263-71, 2014.

Treanor LM, Zhou S, Janke L, Churchman ML, Ma Z, Lu T, Chen SC, Mullighan CG, Sorrentino BP. Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med 211(4):701-13, 2014.

Leung WH, Vong QP, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation. J Exp Med 210(12):2675-92, 2013.

Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR.  Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis. Cell Rep 5(2):340-8, 2013.

Zimmerman EI, Turner DC, Buaboonnam J, Hu S, Orwick S, Roberts MS, Janke LJ, Ramachandran A, Stewart CF, Inaba H, Baker SD. Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. Blood 122(22):3607-15, 2013.

Janke LJ, Liu C, Vogel P, Kawedia J, Boyd KL, Funk AJ, Relling MV. Primary epiphyseal arteriopathy in a mouse model of steroid-induced osteonecrosis.  American Journal of Pathology 183(1):19-25, 2013.

Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR.  Survival Function of the FADD-CASPASE-8-cFLIPL Complex. Cell Reports 1:401-7, 2012.

Last update: August 2019