Kevin R. Krull, PhD
Kevin R. Krull, PhD

Kevin R. Krull, PhD

Member, St. Jude Faculty

  • Endowed Chair in Cancer Survivorship

Departments

Education

MS – Florida State University, Tallahassee (1986)
PhD – Florida State University, Tallahassee (1991)

Research Interests

  • Neurocognitive outcomes of childhood cancer
  • Late effects of cancer therapy
  • Biologic and psychosocial moderators/mediators
  • Treatment of attention executive function problems

Current Research

Selected Publications

Mueller S, Kline CN, Buerki RA, Chen Y, Yasui Y, Howell R, Oeffinger KC, Leisenring WM, Robison LL, Armstrong GT, Fullerton HJ, Krull KR. Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study. Cancer 126(5):1051-1059, 2020.

Krull KR. Dexamethasone and neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 67(3):e28118, 2020.

Tonning Olsson I, Brinkman TM, Wang M, Ehrhardt MJ, Banerjee P, Mulrooney DA, Huang IC, Ness KK, Bishop MW, Srivastava D, Robison LL, Hudson MM, Krull KR. Neurocognitive and psychosocial outcomes in adult survivors of childhood soft tissue sarcoma: A report from the St. Jude Lifetime Cohort. Cancer 126(7):1576-1584, 2020.

Phillips NS, Hillenbrand CM, Mitrea BG, Yan J, Li C, Scoggins MA, Merchant TE, Armstrong GT, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR, Sabin ND. Cerebral microbleeds in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation. Sci Rep 20;10(1):692, 2020.

Karlson CW, Alberts NM, Liu W, Brinkman TM, Annett RD, Mulrooney DA, Schulte F, Leisenring WM, Gibson TM, Howell RM, Srivastava D, Oeffinger KC, Robison LL, Armstrong GT, Zeltzer LK, Krull KR. Longitudinal pain and pain interference in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer Mar 30, 2020. [Epub ahead of print]

Mueller S, Kline CN, Buerki RA, Chen Y, Yasui Y, Howell R, Oeffinger KC, Leisenring WM, Robison LL, Armstrong GT, Fullerton HJ, Krull KR. Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study. Cancer 126(5):1051-1059, 2020.

Sapkota Y, Cheung YT, Moon W, Shelton K, Wilson CL, Wang Z, Mulrooney DA, Zhang J, Armstrong GT, Hudson MM, Robison LL, Krull KR, Yasui Y. Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort study. Clin Cancer Res 25(22):6700-6708, 2019.

Banerjee P, Rossi MG, Anghelescu DL, Liu W, Breazeale AM, Reddick WE, Glass JO, Phillips NS, Jacola LM, Sabin ND, Inaba H, Srivastava D, Robison LL, Pui CH, Hudson MM, Krull KR. Association between anesthesia exposure and neurocognitive and neuroimaging outcomes in long-term survivors of childhood acute lymphoblastic leukemia. JAMA Oncol Jun 20, 2019.  [Epub ahead of print].

Daniel LC, Wang M, Mulrooney DA, Srivastava D, Schwartz LA, Edelstein K, Brinkman TM, Zhou ES, Howell RM, Gibson TM, Leisenring W, Oeffinger KC, Neglia J, Robison LL, Armstrong GT, Krull KR. Sleep, emotional distress, and physical health in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Psychooncology 28(4):903-912, 2019.

Krull KR, Li C, Phillips NS, Cheung YT, Brinkman TM, Wilson CL, Armstrong GT, Khan RB, Merchant TE, Sabin ND, Srivastava D, Pui CH, Robison LL, Hudson MM, Sklar CA, Chemaitilly W. Growth hormone deficiency and neurocognitive function in adult survivors of childhood acute lymphoblastic leukemia. Cancer 125(10):1748-1755, 2019.

Fellah S, Cheung YT, Scoggins MA, Zou P, Sabin ND, Pui CH, Robison LL, Hudson MM, Ogg RJ, Krull KR. Brain activity associated with attention deficits following chemotherapy for childhood acute lymphoblastic leukemiaJ Natl Cancer Inst 111(2):201-209, 2019.

Kesler SR, Ogg R, Reddick WE, Phillips N, Scoggins M, Glass JO, Cheung YT, Pui CH, Robison LL, Hudson MM, Krull KR. Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia. Brain Connect 8(6):333-342, 2018.

Cheung YT, Eskind A, Inaba H, Hudson MM, Pui CH, Krull KR, Wolf J. Association of bacteremic sepsis with long-term neurocognitive dysfunction in pediatric patients with acute lymphoblastic leukemia. JAMA Pediat 172(11):1092-1095, 2018.

Schulte F, Brinkman TM, Li C, Fay-McClymont T, Srivastava DK, Ness KK, Howell RM, Mueller S, Wells E, Strother D, Lafay-Cousin L, Leisenring W, Robison LL, Armstrong GT, Krull KR. Social adjustment in adolescent survivors of pediatric central nervous system tumors: A report from the Childhood Cancer Survivor Study. Cancer 124(17):3596-3608, 2018.

Cheung YT, Khan RB, Liu W, Brinkman TM, Edelmann MN, Reddick WE, Pei D, Panoskaltsis-Mortari A, Srivastava D, Cheng C, Robison LL, Hudson MM, Pui CH, Krull KR. Association of cerebrospinal fluid biomarkers of central nervous system injury with neurocognitive and brain imaging outcomes in children receiving chemotherapy for acute lymphoblastic leukemia. JAMA Oncol 4(7):e180089, 2018.

Cheung YT, Brinkman TM, Li C, Mzayek Y, Srivastava D, Ness KK, Patel SK, Howell RM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR. Chronic health conditions and neurocognitive function in aging survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 110(4):411-419, 2018.

Cheung YT, Brinkman TM, Mulrooney DA, Mzayek Y, Liu W, Banerjee P, Panoskaltsis-Mortari A, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR. Impact of sleep, fatigue and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Cancer 123(17):3410-3419, 2017.

Krull KR, Cheung YT, Liu W, Fellah S, Reddick WE, Brinkman TM, Kimberg C, Ogg R, Srivastava DK, Pui CH, Robison LL, Hudson MM. Chemotherapy pharmacodynamics, neuroimaging and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 34(22):2644-53, 2016.

Brinkman TM, Li C, Vannatta K, Marchak JG, Lai JS, Prasad PK, Kimberg C, Vuotto S, Di C, Srivastava D, Robison LL, Armstrong GT, Krull KR. Behavioral, social and emotional symptom comorbidities and profiles in adolescent survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol 34(28):3417-25, 2016.

Jacola LM, Edelstein K, Liu W, Pui CH, Hayashi R, Kadan-Lottick NS, Srivastava D, Henderson T, Leisenring W, Robison LL, Armstrong GT, Krull KR. Cognitive, behavior and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: A report from the Childhood Cancer Survivor Study. Lancet Psychiatry 3(10):965-972, 2016.

Cheung YT, Sabin ND, Reddick WE, Bhojwani D, Liu W, Brinkman TM, Glass JO, Hwang SN, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR. Leukoencephalopathy and long-term neurobehavioral, neurocognitive and brain imaging outcomes in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy: a longitudinal analysis. Lancet Haematol 3(10):e456-e466, 2016.

Brinkman TM, Krasin MJ, Liu W, Armstrong GT, Ojha RP, Sadighi ZS, Gupta P, Kimberg C, Srivastava D, Merchant TE, Gajjar A, Robison LL, Hudson MM, Krull KR. Long-term neurocognitive functioning and social attainment in adult survivors of pediatric CNS tumors: Results from the St. Jude Lifetime Cohort Study. J Clin Oncol 34(12):1358-67, 2016.

Edelmann MN, Daryani VM, Bishop MW, Liu W, Brinkman TM, Stewart CF, Mulrooney DA, Kimberg C, Ness KK, Cheung YT, Srivastava DK, Robison LL, Hudson MM, Krull KR.  Neurocognitive and Patient-Reported Outcomes in Adult Survivors of Childhood Osteosarcoma. JAMA Oncol 2(2):201-8, 2016.

Fullerton HJ, Stratton K, Mueller S, Leisenring WW, Armstrong GT, Weathers RE, Stovall M, Sklar CA, Goldsby RE, Robison LL, Krull KR. Recurrent stroke in childhood cancer survivors. Neurology 85(12):1056-64, 2015.

Prasad PK, Hardy KK, Zhang N, Edelstein K, Srivastava DK, Zeltzer L, Stovall M, Seibel NL, Leisenring W, Armstrong GT, Robison LL, Krull K. Psychosocial and neurocognitive outcomes in adult survivors of adolescent and early young adult cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol 33(23):2545-52, 2015.

Cheung YT, Krull KR. Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: a systematic review. Neurosci Biobehav Rev 53:108-120, 2015.

Krull KR, Brinkman TM, Li C, Armstrong GT, Ness KK, Gurney JG, Kimberg C, Srivastava DK, Krasin MJ, Pui CH, Robison LL, Hudson MM. Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: a report from the St. Jude lifetime cohort study. J Clin Oncol 31(35):4407-15, 2013.

Krull KR, Zhang N, Srivastava DK, Santucci A, Krasin MJ, Kun LE, Pui CH, Hudson MM, Robison LL, Armstrong GT. Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation. Blood 122(4):550-3, 2013.

Krull KR, Bhojwani D, Conklin H, Pei D, Cheng C, Reddick WE, Sandlund J, Pui CH. Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 31(17):2182-8, 2013.

Krull KR, Sabin ND, Reddick WE, Zhu L. Armstrong GT, Green DM, Arevalo A, Krasin MJ, Srivastava DK, Robison LL, Hudson MM. Neurocognitive function and CNS integrity in adult survivors of childhood Hodgkin lymphoma. J Clin Oncol 30(29):3618-24, 2012.

Last update: April 2020

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