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Seth Karol, MD

Associate Member, St. Jude Faculty

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Contact Information

Seth Karol, MD

Leukemia/Lymphoma

MS 260, Room C6064

St. Jude Children's Research Hospital

262 Danny Thomas Place

MemphisTN 38105-3678

Education

BS – Duke University, Durham, North Carolina

MD – The Ohio State University, Columbus, Ohio

Research Interests

  • Reducing the side effects of therapy in children with acute lymphoblastic leukemia (ALL)
  • Identifying new treatments for children with leukemia after relapse

Clinical Trials

Recruiting
INITIALL: Risk-based Pediatric Leukemia/Lymphoma Treatment

Study goal:

To find out whether a child’s leukemia or lymphoma is low-risk, standard-risk, or high-risk. The risk category will determine the treatment the child will receive. 

Recruiting
SJALL23T: Treatment of Newly Diagnosed Leukemia/Lymphoma

Study goal:

To compare the effects of adding venetoclax, dasatinib, or bortezomib to standard chemotherapy for T-ALL, T-LLy, and MPAL, and to learn more about the biological and genetic or genomic traits that predict treatment success and toxicity in children.

Recruiting
SJALL23H: Treatment of High-Risk Leukemia/Lymphoma

Study goal:

To compare the effects of adding inotuzumab and blinatumomab to standard chemotherapy during treatment for newly diagnosed ALL and LLy; to learn whether the length of time that inotuzumab stays in the body affects treatment success or side effects; to learn more about the biological and genetic or genomic traits that predict treatment success and toxicity in children. 

Dr. Karol in Progress