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Shengdar Tsai, PhD

Associate Member, St. Jude Faculty

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Contact Information

Shengdar Tsai, PhD

Experimental Hematology

MS 355, Room D3022B

St. Jude Children's Research Hospital

262 Danny Thomas Place

MemphisTN 38195-3678

Education

BS – University of Michigan MS – North Carolina State University PhD – North Carolina State University Fellowship – Harvard Medical School / Massachusetts General Hospital

Research Interests

  • Genome Engineering
    • Improving genomic methods to define and measure gene editing “off-target” effects
    • Protein engineering of CRISPR-Cas nucleases for precise gene correction
    • Regulation of DNA damage repair choice between error-prone non-homologous end-joining and precise homology-directed repair
  • Hematology
    • Genome-scale CRISPR-Cas screening for novel effectors of hematological diseases
    • Developing novel strategies for allele-specific editing of genetic mutations that cause sickle cell disease and other hematological disorders

Dr. Tsai in Progress

St. Jude Publications