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Jun J. Yang, PhD
Jun J. Yang, PhD

Jun J. Yang, PhD

Member, St. Jude Faculty

  • Division Director, Pharmacy Sciences
  • Vice-Chair, Department of Pharmacy and Pharmaceutical Sciences
  • Endowed Chair in Pharmacogenomics

Departments

Education

PhD – Purdue University, West Lafayette, Indiana (2006)

Honors and Awards

  • 2024 Mentor of the Year, St. Jude Children’s Research Hospital
  • 2023 American Association of Cancer Research Waun Ki Hong Award for Outstanding Achievement in Translational and Clinical Cancer Research

Research Interests

My primary research interest is to understand genetic basis of inter-patient variability in anticancer drug response, with particular focus on the following aspects of pharmacogenomics of childhood cancer:

  • Pharmacogenomics of anti-leukemia drug toxicities
  • Genomics of anti-leukemia drug sensitivity and resistance (especially molecularly targeted therapeutics)

Selected Publications

Li Z, Zhao H, Yang W, Maillard M, Yoshimura S, Hsiao YC, Huang X, Gocho Y, Rowland L, Brown A, Choi L, Crews KR, Mullighan CG, Brady SW, Cheng C, Chang TC, Wu G, Loh ML, Yeoh AEJ, Antillon-Klussmann F, Jeha S, Inaba H, Yu J, Pui CH, Karol SE, Evans WE, Yang JJ. Molecular and pharmacological heterogeneity of ETV6:RUNX1 acute lymphoblastic leukemia. Nat Commun 2025 Jan 29;16(1):1153. doi: 10.1038/s41467-025-56229-7. PMID: 39880832; PMCID: PMC11779914.

Escherich CS, Moriyama T, Li Z, Hsiao YC, Yang W, Li Y, Reyes N, Walker M, Budhraja A, Bhatara S, Diaz-Flores E, Stock W, Paietta E, Konopleva MY, Kornblau SM, Litzow MR, Inaba H, Pui CH, Opferman JT, Loh ML, Yu J, O'Brien MM, Evans WE, Yang JJ. DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia. Blood 2025 Mar 13;145(11):1182-1194. doi: 10.1182/blood.2024026085. PMID: 39791601; PMCID: PMC11923432.

Yoshimura S, Li Z, Gocho Y, Yang W, Crews KR, Lee SHR, Roberts KG, Mullighan CG, Relling MV, Yu J, Yeoh AEJ, Loh ML, Saygin C, Litzow MR, Jeha S, Karol SE, Inaba H, Pui CH, Konopleva M, Jain N, Stock W, Paietta E, Jabbour E, Kornblau SM, Evans WE, Yang JJ. Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia. J Clin Oncol. 2024 Oct 10;42(29):3478-3490. doi: 10.1200/JCO.24.00500. Epub 2024 Aug 5. PMID: 39102629; PMCID: PMC11458355.

Huang X, Li Y, Zhang J, Yan L, Zhao H, Ding L, Bhatara S, Yang X, Yoshimura S, Yang W, Karol SE, Inaba H, Mullighan C, Litzow M, Zhu X, Zhang Y, Stock W, Jain N, Jabbour E, Kornblau SM, Konopleva M, Pui CH, Paietta E, Evans W, Yu J, Yang JJ. Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia. Cancer Cell. 2024 Apr 8;42(4):552-567.e6. doi: 10.1016/j.ccell.2024.03.003. PMID: 38593781; PMCID: PMC11008188.

Lee SHR, Yang W, Gocho Y, John A, Rowland L, Smart B, Williams H, Maxwell D, Hunt J, Yang W, Crews KR, Roberts KG, Jeha S, Cheng C, Karol SE, Relling MV, Rosner GL, Inaba H, Mullighan CG, Pui CH, Evans WE, Yang JJ. Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response. Nat Med. 2023 Jan;29(1):170-179. doi: 10.1038/s41591-022-02112-7. Epub 2023 Jan 5. PMID: 36604538; PMCID: PMC9873558.

Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. Feb;54(2):170-179, 2022. doi: 10.1038/s41588-021-00993-x. Epub Feb 3, 2022. PMID: 35115686.

Lee SHR, Antillon-Klussmann F, Pei D, Yang W, Roberts KG, Li Z, Devidas M, Yang W, Najera C, Lin HP, Tan AM, Ariffin H, Cheng C, Evans WE, Hunger SP, Jeha S, Mullighan CG, Loh ML, Yeoh AEJ, Pui CH, Yang JJ. Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia. JAMA Oncol. Jan 27:e216826, 2022. doi: 10.1001/jamaoncol.2021.6826. Epub ahead of print. PMID: 35084434.

Li Y, Yang W, Devidas M, Winter SS, Kesserwan C, Yang W, Dunsmore KP, Smith C, Qian M, Zhao X, Zhang R, Gastier-Foster JM, Raetz EA, Carroll WL, Li C, Liu PP, Rabin KR, Sanda T, Mullighan CG, Nichols KE, Evans WE, Pui CH, Hunger SP, Teachey DT, Relling MV, Loh ML, Yang JJ. Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia. J Clin Invest. Jun 24, 2021. doi: 10.1172/KCI147898. PMID: 34166225.

Gocho Y, Liu JJ, Hu J, Yang W, Dharia NV, Zhang J, Shi H, John A, Lin TN, Hunt J, Huang X, Ju B, Rowland L, Shi L, Maxwell D, Smart B, Crews KR, Yang WE, Hagiwara K, Zhang Y, Roberts KR, Wang H, Jabbour E, Stock W, Eisfelder B, Paietta E, Newman S, Roti G, Litzow M, Easton J, Zhang J, Peng J, Chi HB, Pounds S, Relling MV, Inaba H, Zhu X, Kornblau S, Pui CH, Konopleva M, Teachey D, Mullighan CG, Stegmaier K, Evans WE, Yu J, Yang JJ. Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia. Nature Cancer. Jan 21, 2021. doi.org/10.1038/s43018-020-00167-4.

Nishii R, Mizuno T, Rehling D, Smith C, Clark BL, Zhao X, Brown SA, Smart B, Moriyama T, Yamada Y, Ichinohe T, Onizuka M, Atsuta Y, Yang L, Yang WE, Thomas PG, Stenmark P, Kato M, Yang JJ. NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir. Nat Commun 12:4181, 2021. https://doi.org/10.1038/s41467-021-24509-7

Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ. Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. PNAS. Mar 10;117(10):5394 5401, 2020. PMCID: PMC7071893.

Vijayakrishnan J, Qian M, Studd BJB, Yang W, Kinnersley B, Law PJ, Broderick P, Raetz EA, Allan J, Pui CH, Vora A, Evans WE, Moorman A, Yeoh A, Yang W, Li C, Bartram CR, Mullighan CG, Zimmerman M, Hunger SP, Schrappe M, Relling MV, Stanulla M, Loh ML, Houslton RS, Yang JJ. Identification of 1 four novel associations for B-cell acute lymphoblastic leukaemia risk. Nature Communications. Nov 25;10(1):5348, 2019. PMCID: PMC6877561. 

Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui CH, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang JJ. Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children. J Natl Cancer Inst. Apr 2, 2019. Epub ahead of print. PMID: 30938820.

Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema N, Zhang H, Moriyama T, Gastier-Foster J, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, and Yang JJ*. TP53 germline variations influence the predisposition and prognosis of B-cell acute lymphoblastic leukemia in children. J Clin Oncol. Feb 20;36(6), 591-599, 2018. Epub Jan 4, 2018. PMCID: PMC5815403.

Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, Lin T-N, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham S, Isobe T, Chen Z, Chiew E, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui C-H, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AEJ, Evans WE, and Yang JJ*NUDT15 Polymorphisms Alter Thiopurine Metabolism and Hematopoietic Toxicity. Nat Genet. Apr; 48(4):367-73, 2016. PMCID: PMC5029084. 

Moriyama T, Metzger ML, Wu, G, Nishii, R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster J, Raetz E, Larsen E, Martin PL, Bowman WP,  Winick N, Komada Y, Wang S, Edmonson M, Xu H, Mardis E, Fulton R, Pui C-H, Mullighan C, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ*. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. Lancet Oncol. Dec;16(16):1659-66, 2015. PMCID: PMC4684709.

Xu H, Robinson GW, Huang J, Lim JY, Zhang H, Bass JK, Broniscer A2, Chintagumpala M, Bartels U, Gururangan S, Hassall T, Fisher M, Cohn R, Yamashita T, Teitz T, Zuo J, Onar-Thomas A, Gajjar A, Stewart CF, Yang JJ*.  Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss. Nat Genet. Mar; 47 (3):263-6, 2015. PMCID: PMC4358157.

Yang JJ*, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay NM, Wong FL, Evans WE, Pui C-H, Bhatia S, and Relling MV. Inherited NUDT15 Variant is a Genetic Determinant of Mercaptopurine Intolerance in Children with Acute Lymphoblastic Leukemia. J Clin Oncol. Apr 10;33(11):1235-42, 2015. PMCID: PMC4375304.

Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier-Foster J, E S, Lim JY, Chen IM, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Klussmann FA, Villagran CR, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui CH, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ*. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet. 45(12):1494-8, 2013. PMCID: PMC4039076.

Yang JJ*, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox NJ, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui C-H, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet. 43(3):237-241, 2011. PMCID: PMC3104508.

Yang JJ*, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds S, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui C, Devidas M, Bowman WP, Camitta BM, Willman C, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, Relling MV. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA 301(4):393-403, 2009. PMCID: PMC2664534. 

See full list of publications

Last update: April 2025

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