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Member, St. Jude Faculty
Director, Division of Developmental Biology
Co-Leader, Developmental Therapeutics for Solid Malignancies Program
Developmental Neurobiology
Developmental Biology
Michael Dyer, PhD
Developmental Neurobiology
MS 324, Room D2039D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: michael.dyer@stjude.org
Phone: (901) 595-2257
FAX: (901) 595-7641
PhD - Harvard University, Cambridge, Massachusetts
Michael Dyer received his bachelor’s degree with honors from UCLA in Microbiology and Molecular Genetics. For his doctoral training, Dr. Dyer went to Harvard University where he studied globin gene switching during hematopoiesis with Dr. Margaret Baron. After completing his degree, he moved to Harvard Medical School for a postdoctoral fellowship with Dr. Connie Cepko. In Connie’s lab he became interested in the regulation of retinal progenitor cell proliferation during neurogenesis. In 2002, Dr. Dyer was recruited to the department of Developmental Neurobiology at St. Jude Children’s Research Hospital. At St. Jude, he expanded his interest in neural progenitor cell proliferation to include cancer biology, evolutionary biology and stem cell biology. In 2005, he was promoted to Associate Member and in 2008 he was promoted to Member at St. Jude. He has received numerous awards since joining the faculty at St. Jude including being named a Pew Scholar, the Cogan Award Recipient and a Howard Hughes Medical Institute Early Career Scientist. In 2009, Dr. Dyer was named co-leader of the Solid Tumor Program in the NCI designated comprehensive cancer center at St. Jude Children’s Research Hospital and in 2011 he was named head of the Division of Developmental Biology.
McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan RC, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma, Cancer cell. Cancer Cell Aug 16;20(2):260-75, 2011. Faculty of 1000 (F1000)
Brennan RC, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart CF, Zhu F, Guy K, Dyer MA. Targeting the p53 Pathway in Retinoblastoma with Subconjunctival Nutlin-3a. Cancer Res Apr 22, 2011. [Epub ahead of print]. PMCID: PMC3116943. Faculty of 1000 (F1000)
Nemeth K, Federico S, Angel MC, Shen Y, Schaiquevich P, Zhang J, Egorin M, Stewart C, Dyer MA. Subconjunctival Carboplatin and Systemic Topotecan Treatment in Preclinical Models of Retinoblastoma. Cancer Jan 15;117(2):421-34, 2011. PMCID: PMC3000447.
Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. Biol Chem 285(14):10786-96, 2010. (Epub 2010 Jan 15, 2010 Apr 2). PMCID: PMC2856285.
Laurie N, Mohan A, McEvoy J, Reed D, Zhang J, Schweers B, Ajioka I, Valentine V, Johnson D, Ellison D, Dyer MA. Changes in retinoblastoma cell adhesion associated with optic nerve invasion. Mol Cell Biol Dec;29(23):6268-82, 2009. Epub 2009 Sep 28. PMCID: PMC2786692
Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci USA Jun 2;106(22):8963-8968, 2009. Epub 2009 May 18.
Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci USA Apr 21;106(16):6685-90, 2009. Epub 2009 Apr 3.
Ajioka I, Dyer MA. A New Model of Tumor Susceptibility Following Tumor Suppressor Gene Inactivation. Cell Cycle 11;7(6):735-40, 2008.
Martins RAP, Zindy F, Donovan S, Zhang J, Pounds S, Knoepfler PS, Eisenman RN, Roussel M, Dyer MA. N-myc coordinates retinal growth with eye size during mouse development. Genes and Development 15;22(2):179-193, 2008. PMCID: PMC2192753
Pounds S, Dyer MA. Statistical analysis of data from retroviral clonal experiments in the developing retina. Brain Research 1192:178-85, 2008.
Ajioka I, Martins R, Bayazitov I, Johnson D, Frase S, Donovan SL, Boyd K. Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 131(2):378-90, 2007. PMCID: PMC2203617
Laurie N, Schin-Shih C, Dyer MA. Targeting MDM2 and MDMX in Retinoblastoma. Current Cancer Drug Targets 7(7):689-95, 2007.
Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes and Development 21(14):1731-46, 2007.
MacPherson D, Dyer MA. Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy. Cancer Res 67(16):7547-50, 2007.
Johnson DA, Zhang J, Frase S, Dyer MA. Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res 67(6):2701-11, 2007.
Donovan SL, Dyer MA. Preparation and square-wave electroporation of retinal explant cultures. Nat Protocols 1:2710-2718, 2007.
Laurie N, Donovan S, Gray J, Fuller C, Johnson D, Wilson M, Rodriguez-Galindo C, Marine J-C, Jochemsen AG, Mendrysa S, Dyer MA. Inactivation the p53 pathway in retinoblastoma. Nature 444:61-66, 2006.
Marine J-C, Dyer MA, Jochemsen AG. MDMX: from Bench to Bedside. J Cell Sci 120: 371-378, 2007.
Martins RAP, Linden R, Dyer MA. Glutamate regulates retinal progenitor cells proliferation during development. Eur J Neurosci 24:969-980, 2006.
Johnson D, Donovan S, Dyer MA. Mosaic deletion of Rb arrests rod differentiation and stimulates ectopic synaptogenesis in the mouse retina. J Comp Neurol 498:112-128, 2006.
Donovan SL, Schweers BA, Zhang J, Martins RA, Johnson DJ, Dyer MA. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biology 4:14 (open access), 2006.
Sun H, Chang Y, Schweers B, Dyer MA, Zhang X, Hayward SW, Goodrich DW. An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity. Mol Cell Biol 26:1527-1537, 2006.
Dyer MA, Rodriguez-Galindo C, Wilson MW. Use of preclinical models to improve treatment of retinoblastoma. PLOS Med 2:971-976, 2005.
Laurie NA, Gray JK, Zhang J, Leggas M, Relling M, Egorin M, Stewart C, Dyer MA. Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clin Cancer Res 11:7569-7578, 2005.
Schweers B, Dyer MA. Perspective: new genetic tools for studying retinal development and disease. Vis Neurosci 22:553-560, 2005.
Donovan SL, Dyer MA. Regulation of proliferation in the developing central nervous system. Semin Cell Dev Biol 16:407-421, 2005.
Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. Nat Rev Cancer 5:91-101, 2005.
Zhang J, Schweers B, Dyer MA. The first knockout mouse model of retinoblastoma. Cell Cycle 3:952-959, 2004.
Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet 36:351-360, 2004.
Last update: September 2011
