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Finding Cures. Saving Children.
Michael A. Dyer, PhD
Member, St. Jude Faculty
Co-Leader, Developmental Therapeutics for Solid Malignancies Program
Departments
Developmental Neurobiology
Contact Information
Michael Dyer, PhD
Developmental Neurobiology
DTRC Room D2025C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: michael.dyer@stjude.org
Phone: (901) 595-2257
FAX: (901) 595-3143
Education
PhD - Harvard University, Cambridge, Massachusetts
Research Interests
- Coordination of proliferation and differentiation during neurogenesis
- Retinal disease and stem cell based therapies
- Retinoblastoma and targeted chemotherapy
- Pediatric solid malignancies
- High throughput screening and drug discovery
- Computational approaches to analyze complex image data sets
Selected Publications
Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci USA Jun 2;106(22):8963-8968, 2009. Epub 2009 May 18.
Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci USA Apr 21;106(16):6685-90, 2009. Epub 2009 Apr 3.
Ajioka I, Dyer MA. A New Model of Tumor Susceptibility Following Tumor Suppressor Gene Inactivation. Cell Cycle 11;7(6):735-40, 2008.
Martins RAP, Zindy F, Donovan S, Zhang J, Pounds S, Knoepfler PS, Eisenman RN, Roussel M, Dyer MA. N-myc coordinates retinal growth with eye size during mouse development. Genes and Development 15;22(2):179-193, 2008. PMCID: PMC2192753
Pounds S, Dyer MA. Statistical analysis of data from retroviral clonal experiments in the developing retina. Brain Research 1192:178-85, 2008.
Ajioka I, Martins R, Bayazitov I, Johnson D, Frase S, Donovan SL, Boyd K. Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 131(2):378-90, 2007. PMCID: PMC2203617
Laurie N, Schin-Shih C, Dyer MA. Targeting MDM2 and MDMX in Retinoblastoma. Current Cancer Drug Targets 7(7):689-95, 2007.
Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes and Development 21(14):1731-46, 2007.
MacPherson D, Dyer MA. Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy. Cancer Res 67(16):7547-50, 2007.
Johnson DA, Zhang J, Frase S, Dyer MA. Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res 67(6):2701-11, 2007.
Donovan SL, Dyer MA. Preparation and square-wave electroporation of retinal explant cultures. Nat Protocols 1:2710-2718, 2007.
Laurie N, Donovan S, Gray J, Fuller C, Johnson D, Wilson M, Rodriguez-Galindo C, Marine J-C, Jochemsen AG, Mendrysa S, Dyer MA. Inactivation the p53 pathway in retinoblastoma. Nature 444:61-66, 2006.
Marine J-C, Dyer MA, Jochemsen AG. MDMX: from Bench to Bedside. J Cell Sci 120: 371-378, 2007.
Martins RAP, Linden R, Dyer MA. Glutamate regulates retinal progenitor cells proliferation during development. Eur J Neurosci 24:969-980, 2006.
Johnson D, Donovan S, Dyer MA. Mosaic deletion of Rb arrests rod differentiation and stimulates ectopic synaptogenesis in the mouse retina. J Comp Neurol 498:112-128, 2006.
Donovan SL, Schweers BA, Zhang J, Martins RA, Johnson DJ, Dyer MA. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biology 4:14 (open access), 2006.
Sun H, Chang Y, Schweers B, Dyer MA, Zhang X, Hayward SW, Goodrich DW. An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity. Mol Cell Biol 26:1527-1537, 2006.
Dyer MA, Rodriguez-Galindo C, Wilson MW. Use of preclinical models to improve treatment of retinoblastoma. PLOS Med 2:971-976, 2005.
Laurie NA, Gray JK, Zhang J, Leggas M, Relling M, Egorin M, Stewart C, Dyer MA. Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clin Cancer Res 11:7569-7578, 2005.
Schweers B, Dyer MA. Perspective: new genetic tools for studying retinal development and disease. Vis Neurosci 22:553-560, 2005.
Donovan SL, Dyer MA. Regulation of proliferation in the developing central nervous system. Semin Cell Dev Biol 16:407-421, 2005.
Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. Nat Rev Cancer 5:91-101, 2005.
Last update: June 2009
