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Research
Member, St. Jude Faculty
Adjunct Professor, UT Health Science Center
Chemical Biology & Therapeutics
Richard Lee, PhD
Chemical Biology & Therapeutics
MS 1000, Room E9053
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: richard.lee@stjude.org
Phone: (901) 595-6617
FAX: (901) 595-5715
PhD – University of Newcastle-upon-Tyne, United Kingdom
Zhao Y, Hammoudeh D, Yun MK, Qi J, White SW, Lee RE. Structure-based design of novel pyrimido[4,5-c]pyridazine derivatives as dihydropteroate synthase inhibitors with increased affinity. ChemMedChem March 13, 2012.
Yun MK, Wu Y, Li Z, Zhao Y, Waddell MB, Ferreira AM, Lee RE, Bashford D, White SW. Catalysis and sulfa drug resistance in dihydropteroate synthase. Science 335(6072):1110-4, 2012.
Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol February 19, 2012.
Hurdle JG, Heathcott AE, Yang L, Yan B, Lee RE. Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations. J Antimicrob Chemother June 1, 2011.
Hurdle JG, O'Neill AJ, Chopra I, Lee RE. Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat Rev Microbiol 9(1):62-75, 2011.
Hevener KE, Yun MK, Qi J, Kerr ID, Babaoglu K, Hurdle JG, Balakrishna K, White SW, Lee RE. Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase. J Med Chem 53(1):166-177, 2010.
Budha NR, Lee RB, Hurdle JG, Lee RE, Meibohm B. A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria. Tuberculosis (Edinb) Sep;89(5):378-85, 2009.
Mahrous EA, Lee RB, Lee RE. Lipid profiling using two-dimensional heteronuclear single quantum coherence NMR. Methods Mol Biol 579:89-102, 2009.
Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE. Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors. Chem Med Chem 2009 Oct;4(10):1649-56, 2009.
Hurdle JG, Yendapally R, Sun D, Lee RE. Evaluation of analogs of reutericyclin as prospective candidates for the treatment of staphylococcal skin infections. Antimicrob Agents Chemother Jul 6, 2009. [Epub ahead of print] PMID: 19581456.
Zhao W, Hevener KE, White SW, Lee RE, Boyett JM. A Statistical Framework to Evaluate Virtual Screening. BMC Bioinformatics Jul 20;10:225, 2009.
Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE. Discovery, Synthesis, and Biological Evaluation of Piperidinol analogs With Anti-tuberculosis Activity. Bioorg Med Chem May 15;17(10):3588-94, 2009.
Hevener K, Zhao W, Ball D, Babaoglu K, Qi J, White S, Lee RE. Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase. J Chem Inf Mod 49 (2), 444–460, 2009.
Aubry S, Lee RE, Mahrous EA, Small PL, Beachboard D, Kishi Y. Synthesis and Structure of Mycolactone E Isolated from Frog Mycobacterium. Org Lett 10 (23), 5385–5388, 2008.
Grimes KD, Lu Y, Zhang Y-M, Luna VA, Hurdle JG, Carson EI, Qi J, Kudrimoti S, Rock CO, Lee RE. Novel Acylphosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria. ChemMedChem 3 :1936-45, 2008.
Hevener KE, Ball DM, Buolamwini JK, Lee RE. Quantitative structure–activity relationship studies on nitrofuranyl anti-tubercular agents. Bioorganic and Medicinal Chemistry Sep 1;16(17):8042-53, 2008.
Hurdle J, Lee RB, Budha N, Scherman M, Carson E, Qi J, Jianjun, Cho S, Lenaerts A, Franzblau S, Meibohm BM, Bernd, Lee RE. A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. Journal of Antimicrobial Chemotherapy Nov;>62(5):1037-45, 2008.
Rakesh, Sun D, Lee RB, Tangallapally R, Lee RE. Synthesis, Optimization and Structure-Activity Relationships of 3,5-Disubstituted Isoxazolines as New Anti-tuberculosis Agents. Eur J Med Chem Feb;44(2):460-72, 2009.
Portaels F, Meyers WM, Ablordey A, Castro AG, Chemlal K, de Rijk P, Elsen P, Fissette K, Fraga AG, Lee R, Mahrous E, Small PL, Stragier P, Torrado E, Van Aerde A, Silva MT, Pedrosa J. First Cultivation and Characterization of Mycobacterium ulcerans from the Environment. PLoS Negl Trop Dis Mar 26;2(3):e178, 2008.
Budha NR, Mehrotra N, Tangallapally R, Rakesh, Qi J, Daniels AJ, Lee RE, Meibohm B. Pharmacokinetically-Guided Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents. The AAPS Journal 10(1):157-65, 2008.
Yendapally R, Lee RE. Design, Synthesis and Evaluation of Novel Ethambutol Analogues. Bioorg Med Chem Lett Mar 1;18(5):1607-11, 2008.
Budha NR, Lee RE, Meibohm B. Biopharmaceutics, Pharmacokinetics and Pharmacodynamics of Antituberculosis Drugs. Curr Med Chem 15(8):809-25, 2008.
Yendapally R, Hurdle JG, Carson EI, Lee RB, Lee RE. N-Substituted 3-Acetyl Tetramic acid Derivatives as Antibacterial Agents. J Med Chem Mar 13;51(5):1487-91, 2008.
Mahrous EA, Lee RB, Lee RE. A rapid approach to lipid profiling of mycobacteria using 2D HSQC NMR maps. J Lipid Res Feb;49(2):455-63, 2008.
Sun D, Jones V, Carson EI, Lee RE, Scherman MS, McNeil MR, Lee RE. Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library. Bioorg Med Chem Lett 17: 6899, 2007.
Sun D, Rakesh, Budha N, Lee REB, Lenaerts AJM, Meibohm B, RE Lee. Discovery of Novel Isoxazolines as Anti-tuberculosis Agents RP Tangallapally. Bioorg Med Chem Lett 17 :6638, 2007.
Bennett BC, Xu H, Simmerman RF, Lee RE, Dealwis CG. Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase. J Med Chem 50(18):4374-81, 2007.
Sun D, RE Lee. High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics. High-Throughput Lead Optimization in Drug Discovery Ed. T Kshirsagar, CRC press, Vol. 3, Ch. 9, pp 215-238, 2008.
Sun D, Lee RE. Solid-Phase Synthesis of a Thymidinyl Dipeptide Urea Library. J Comb Chem May-Jun;9(3):370-85, 2007.
Zhang YM, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, Jackowski S. Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis. Chem Biol Mar;14(3):291-302, 2007.
Lu YJ, Zhang F, Grimes KD, Lee RE, Rock CO. Topology and active site of plsy: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. J Biol Chem Apr 13;282(15):11339-46, 2007.
Tangallapally RP, Yendapally R, Daniels AJ, Lee REB, Lee RE. Nitrofurans as Novel Anti-tuberculosis Agents: Identification, Development and Evaluation. Curr Top Med Chem 7(5):509-26, 2007.
Hasty DL, Meron-Sudai S, Cox KH, Nagorna T, Ruiz-Bustos E, Losi E, Courtney HS, Mahrous EA, Lee R, Ofek I. Monocyte and macrophage activation by lipoteichoic Acid is independent of alanine and is potentiated by hemoglobin. J Immunol May 1;176(9):5567-76, 2006.
Lu YJ, Zhang Y-M, Grimes KD, Qi J, Lee RE, Rocki CO. Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens. Molecular Cell Sep 1;23(5):765-72, 2006.
Ranger BS, Mahrous EA, Mosi L, Adusumilli S, Lee RE, Colorni A, Rhodes M, Small PL. Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F. Infect Immun Nov;74(11):6037-45, 2006.
Yoon KJ, Qi J, Remack JS, Virga KG, Hatfield MJ, Potter PM, Lee RE, Danks MK. Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy. Molecular Cancer Therapeutics Jun;5(6):1577-84, 2006.
Tangallapally RP, Lee REB, Lenaerts AJM, Lee RE. Synthesis of new and potent analogs of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailabilty. Bioorg Med Chem Lett 16, 2584-9, 2006.
Last updated: March 2012
