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Finding Cures. Saving Children.
Thomas E. Merchant, DO, PhD
Member, St. Jude Faculty
Division Chief, Radiation Oncology
Departments
Radiological Sciences
Divisions
Radiation Oncology
Contact Information
Thomas Merchant, DO, PhD
Radiological Sciences
Radiation Oncology
MS 220, Room I-3131
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: thomas.merchant@stjude.org
Phone: (901) 595-3604
FAX: (901) 595-3113
Education
DO - Chicago College of Osteopathic Medicine, Chicago, Illinois
PhD - University of Utrecht, The Netherlands
Research Interests
- Brain tumors
Selected Publications
Hoehn ME, Merchant TE, Chaum E. Macular epiretinal membrane formation in a child with papilledema from a craniopharyngioma. Retinal Cases & Brief Reports 2008 (in press).
Merchant TE, Boop FA, Kun LE, Sanford RA. A Retrospective Study of Surgery and Re-Irradiation for Recurrent Ependymoma. Int J Radiat Oncol Biol Phys 2008 (in press).
Hartley KA, Li C, Laningham FH, Krasin MJ, Xiong X, Merchant TE. Vertebral body growth after craniospinal irradiation. Int J Radiat Oncol Biol Phys Dec 28, 2007. [Epub ahead of print]
Merchant TE, Bosley C, Smith J, Baratti P, Pritchard D, David T, Li C, Xiong X. A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients. Radiat Oncol Dec 19;21:45, 2007. [Epub ahead of print]
Merchant TE, Kun LE, Krasin MJ, Wallace D, Chintagumpala M, Woo S, Ashley DM, Sexton M, Kellie SJ, Ahern V, Gajjar A. a multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys Sep 22; 2007. [Epub ahead of print]
Hudson MM, Rai SN, Nunez C, Merchant TE, Marina N, Zalamea N, Cox C, Phipps S, Pompeu R, Rosenthal D Non-Invasive Evaluation of Late Anthracycline Cardiac Toxicity in Childhood Cancer. J Clin Oncol Aug 20;25(24):3635-43, 2007.
Sanders RP, Kocak M, Burger PC, Merchant TE, Gajjar A, Broniscer A. High-grade astrocytoma in very young children. Pediatr Blood Cancer Dec;49(7):888-93, 2007. Epub 2007 Jun 6.
Klosky JL, Tyc VL, Tong X, Srivastava DK, Kronenberg M, de Armendi AJ, Merchant TE. Predicting pediatric distress during radiation therapy procedures: the role of medical, psychosocial, and demographic factors. Pediatrics May; 119(5):e1159-66, 2007. Epub 2007 Apr 23.
Morris EB, Gajjar A, Okuma JO, Yasui Y, Wallace D, Kun LE, Merchant TE, Fouladi M, Broniscer A, Robison LL, Hudson MM. Survival and late mortality in long-term survivors of pediatric CNS tumors. J Clin Oncol Apr 20;25(12):1532-8, 2007.
Krasin MJ, Xiong X, Reddick WE, Ogg RJ, Hoffer FA, McCarville B, Kaste SC, Spunt SL, Navid F, Davidoff AM, Zhang L, Kun LE, Merchant TE. A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation. Magn Reson Imaging Dec;24(10):1319-24, 2006. Epub 2006 Oct 25.
Hua C, Shukla HI, Merchant TE, Krasin MJ. Estimating differences in volumetric flat bone growth in pediatric patients by radiation treatment method. Int J Radiat Oncol Biol Phys Feb 1;67(2):552-558, 2007. Epub 2006 Nov 9.
Kiehna EN, Mulhern RK, Li C, Xiong X, Merchant TE. Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy. J Clin Oncol Nov 20;24(33):5283-90, 2006.
Yuan H, Gaber MW, Boyd K, Wilson CM, Kiani MF, Merchant TE. Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes. Int J Radiat Oncol Biol Phys Nov 1;66(3):860-6, 2006.
Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol Oct;7(10):813-20, 2006. Erratum in: Lancet Oncol Oct;7(10):797, 2006.
Poltinnikov IM, Merchant TE. CSF Cytology has limited value in the evaluation of patients with ependymoma who have MRI evidence of metastasis. Pediatr Blood Cancer Sep 30; [Epub ahead of print], 2005. Pediatr Blood Cancer Aug;47(2):169-73, 2006.
Merchant TE, Kiehna EN, Li C, Shukla H, Sengupta S, Xiong X, Gajjar A, Mulhern RK. Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma. Int J Radiat Oncol Biol Phys May 1;65(1):210-21, 2006. Epub 2006 Feb 10.
Reeves CB, Palmer, SL, Reddick WE, Merchant TE, Buchanan GM, Gajjar A, Mulhern RK. Attention and memory functioning among pediatric patients with medulloblastoma. J Pediatr Psychol Apr 31(3):272-80, 2006.
Merchant TE. Craniopharyngioma Radiotherapy: Endocrine and Cognitive Effects. J Pediatr Endocrinol Metab Apr;19 Suppl 1:439-46, 2006.
Navid F, Santana VM, Billups CA, Merchant TE, Furman WL, Spunt SL, Cain AM, Rao BN, Hale GA, Pappo AS. Concomitant administration of vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for high-risk sarcomas: the St. Jude Children’s Research Hospital experience. Cancer Apr 15;106(8):1846-56, 2006.
Broniscer A, Chintagumpala M, Fouladi M, Krasin MJ, Kocak M, Bowers DC, Iacono LC, Merchant TE, Stewart CF, Houghton PJ, Kun LE, Ledet D, Gajjar A. Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children. J Neurooncol Feb; 76(3):313-319, 2006.
Merchant TE, Kiehna EN, Kun LE, Mulhern RK, Li C, Xiong X, Boop FA, Sanford RA. Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function. J Neurosurg Feb;104(2 Suppl):94-102, 2006.
Metzger ML, Howard SC, Hudson MM, Gow KW, Li CS, Krasin MJ, Merchant T, Kun L, Shelso J, Pui CH, Shochat SJ, McCarville MB. Natural history of thyroid nodules in survivors of pediatric Hodgkin lymphoma. Pediatr Blood Cancer Mar;46(3):314-9, 2006.
Broniscer A, Laningham FH, Kocak M, Krasin MJ, Fouladi M, Merchant TE, Kun LE, Boyett JM, Gajjar A. Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma. Cancer Mar 15:106(6):1364-71, 2006. Epub Feb 6, 2006.
Merchant TE, Kiehna EN, Li C, Xiong X, Mulhern RK. Radiation dosimetry predicts IQ after conformal radiation therapy in pediatric patients with localized ependymoma. Int J Radiat Oncol Biol Phys Dec 1;63(5):1546-54, 2005. Epub Aug 22, 2005.
Merchant TE, Fouladi M. Ependymoma: new therapeutic approaches including radiation and chemotherapy. J Neurooncol Dec;75(3):287-99, 2005.
Krasin MJ, Rai SN, Kun LE, Merchant TE, Metzger ML, Kaste SC, Howard SC, Hudson MM. Patterns of treatment failure in pediatric and young adult patients with Hodgkin’s disease: local disease control with combined-modality therapy. J Clin Oncol Nov 20;23(33):8406-13, 2005.
Fouladi M, Gilger E, Kocak M, Wallace D, Buchanan G, Reeves C, Robbins N, Merchant TE, Kun LE, Khan R, Mulhern RK. Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies. J Clin Oncol Oct 1;23(28):7152-60, 2005.
Wilson MW, Haik BG, Liu T, Merchant TE, Rodriguez-Galindo C. Effect on ocular survival of adding early intensive focal treatments to a two-drug chemotherapy regimen in patients with retinoblastoma. Am J Ophthalmol Sep;140(3):397-406, 2005.
Mulhern RK, Palmer SL, Merchant TE, Wallace D, Kocak M, Brouwers P, Krull K, Chintagumpala M, Stargatt R, Ashley DM, Tyc VL, Kun L, Boyett J, Gajjar A. Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. J Clin Oncol Aug 20;23(4):5511-19, 2005.
Krasin MJ, Xiong A, Wu S, Merchant TE. The effects of external beam irradiation on the growth of flat bones in children: modeling a dose-volume effect. Int J Radiation Oncology Biol Phys Aug 1;62(5):1458-63, 2005.
Krasin MJ, Xiong X, Wu S, Merchant TE. Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors. Cancer Jul 15;104(2):367-73, 2005.
Khan RB, Hunt DL, Boop FA, Sanford RA, Merchant TE, Gajjar A, Kun LE. Seizures in children with primary brain tumors: incidence and long-term outcome. Epilepsy Res May;64(3):85-91, 2005.
Yuan H, Goetz DJ, Gaber MW, Issekutz AC, Merchant TE, Kiani MF. Radiation-induced up-regulation of adhesion molecules in brain microvasculature and their modulation by dexamethasone. Radiat Res May;163(5):544-551, 2005.
Helton KJ, Edwards M, Steen RG, Merchant TE, Sapp MV, Boop FA, Langston J. Neuroimaging-detected late transient treatment-induced lesions in pediatric patients with brain tumors. J Neurosurg Mar;102(2 Suppl):179-86, 2005.
Reeves CB, Palmer SL, Reddick WE, Merchant TE, Buchanan GM, Gajjar A, Mulhern RK. Attention and memory functioning among pediatric patients with medulloblastoma. J Pediatr Psychol Apr;31(3):272-80, 2006. Epub Mar 23, 2005.
Tekautz TM, Fuller CE, Blaney S, Fouladi M, Broniscer A, Merchant TE, Krasin M, Dalton J, Hale G, Kun LE, Wallace D, Gilbertson RJ, Gajjar A. Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy. J Clin Oncol Mar 1;23(7):1491-9, 2005.
Last update: July 2008
